Abstracts tagged "osteoarthritis and transforming growth factor"

Abstract Number: 762 • ACR/ARHP Annual Meeting 2013
Inhibition Of TGF-Beta Signaling In Articular Chondrocytes Leads To OA-Like Pathological Defects and Pain-Related Behavior Change In Mice
Jia Li¹, Jie Shen², Shan Li¹, John Dickerson¹, Jeffrey Kroin¹, Hee-Jeong Im¹ and Di Chen¹, ¹Rush University, Chicago, IL, ²University of Rochester, Rochester, NY
Background/Purpose: TGF-β signaling plays an important role in chondrocyte differentiation and osteoarthritis (OA) pathogenesis. However TGF-β downstream target genes and signaling mechanism in OA development…