Abstracts tagged "osteoarthritis and transcription factor"

Abstract Number: 2733 • ACR/ARHP Annual Meeting 2013
Spontaneous Osteoarthritis In Mice By Genetic Deletion Of Nfatc1 and Nfatc2
Susan Y. Ritter¹, Matthew B. Greenblatt², Kelly Tsang¹, Dorothy Z. Hu³, John Wright⁴ and Antonios O. Aliprantis¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Pathology, Brigham and Women's Hospital, Boston, MA, ³Endocrine Unit, Massachusetts General Hospital, Boston, MA, ⁴Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Osteoarthritis (OA) was once viewed as a mechanical disease of “wear and tear”, but recent advances suggest that OA results from active dysregulation of…