Abstracts tagged "osteoarthritis and subchondral bone"

Abstract Number: 436 • ACR/ARHP Annual Meeting 2018
Structural Effects of Intra-Articular Sprifermin in Symptomatic Radiographic Knee Osteoarthritis: A Post-Hoc Analysis of Cartilage Morphology over the 2-Year Treatment-Period of a 5-Year Randomized, Placebo-Controlled, Phase II Study
Ali Guermazi¹, Jeffrey Kraines², Aida Aydemir², Stephen Wax³, Michel Crema⁴, Marc C. Hochberg⁵ and Frank Roemer^1,6, ¹Radiology, Boston University School of Medicine, Boston, MA, ²EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), Billerica, MA, ³EMD Serono Research & Development Institute, Inc. (a business of Merck KGaA, Darmstadt, Germany), BIllerica, MA, ⁴Boston University School of Medicine, Boston, MA, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Department of Radiology, University of Erlangen-Nuremberg, Erlangen, Germany, Erlangen, Germany
Background/Purpose: Sprifermin, a recombinant human fibroblast growth factor 18, is currently being investigated as a potential disease-modifying OA drug. Sprifermin treatment leads to a dose-dependent…
Abstract Number: 1130 • ACR/ARHP Annual Meeting 2015
Global DNA Methylation Analysis of Osteoarthritic Subchondral Bone Reveals Significant Regional Variation and Similarity to Overlying Cartilage
Matlock A. Jeffries^1,2, Madison Andrews³, Mary Beth Humphrey¹, Judith A. James⁴ and Amr H. Sawalha⁵, ¹Rheumatology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ²Arthritis and Clinical Immunology, Oklahoma Medical Research Association, Oklahoma City, OK, ³Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, ⁴Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, ⁵Univers, Oklahoma City, OK
Background/Purpose: Osteoarthritis (OA) is a leading cause of chronic disability affecting a majority of individuals over age 70. Outside of cartilage, little is known regarding…
Abstract Number: 1007 • ACR/ARHP Annual Meeting 2014
Markedly Increased Mesenchymal Stem Cell Activity in MRI Bone Marrow Lesions Compared with Non-Involved Bone in Osteoarthritic Hips
T Mark Campbell¹, Frederique Ponchel², Alexandro Gomez³, Richard J. Hodgson², Dennis McGonagle⁴, Philip G. Conaghan⁵ and Elena Jones³, ¹Medicine, The Ottawa Hospital Rehabilitation Centre, Ottawa, ON, Canada, ²NIHR-Leeds Musculoskeletal Biomedical Research Unit and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ³Leeds Musculoskeletal Biomedical Research Unit, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR, Leeds, United Kingdom, ⁴Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ⁵Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom
Background/Purpose Multipotent mesenchymal stem cells (MSCs) are critical for bone and cartilage repair but the role of such cells in vivo in hip OA is…