Abstracts tagged "osteoarthritis and post-translational modification"

Abstract Number: 60 • ACR/ARHP Annual Meeting 2013
O-Linked N-Acetylglucosamine Modified Proteome Of Human Osteoarthritic Cartilage: Biological Significance
Jessica Andrés-Bergós^1,2, María Luisa Hernáez³, Miguel Otero², Ane Larranaga-Vera¹, Sandra Pérez-Baos¹, Mary B. Goldring², Gabriel Herrero-Beaumont¹ and Raquel Largo⁴, ¹Joint and Bone Research Unit. IIS-Fundación Jiménez Díaz. UAM, Madrid, Spain, ²Tissue Engineering Repair and Regeneration Program, Hospital for Special Surgery and Weill Cornell Medical College, New York, NY, ³Proteomics Unit, Universidad Complutense de Madrid-Parque Científico de Madrid, ProteoRed ISCIII, Madrid, Spain, ⁴Bone and Joint Research Unit, IIS-Fundación Jiménez Díaz, Madrid, Spain
Background/Purpose: O-linked N-acetylglucosamine (O-GlcNAc) post-translational modifications have been implicated in the control of different signaling cascades and in the development and progression of degenerative and…