Abstracts tagged "osteoarthritis and polymorphism"

Abstract Number: 1100 • 2012 ACR/ARHP Annual Meeting
A Functional Growth Hormone Receptor Polymorphism, Exon 3 Deleted Ghr, Is Associated with Radiographic Knee Osteoarthritis in Females with Familial Osteoarthritis At Multiple Sites: The Garp Study
Kim M.J.A. Claessen¹, Margreet Kloppenburg², H.M. Kroon³, Jessica Bijsterbosch⁴, Alberto M. Pereira¹, Hans A. Romijn¹, Tahar Straaten van der⁵, Marian Beekman⁶, P.E. Slagboom⁶, Nienke R. Biermasz¹ and Ingrid Meulenbelt⁷, ¹Endocrinology, Leiden University Medical Center, Leiden, Netherlands, ²Department Rheumatology and Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, Netherlands, ⁶Molecular Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ⁷The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Rotterdam, Netherlands
Background/Purpose: Genetic influences contribute considerably to the development of osteoarthritis (OA), and are most likely of a polygenic nature. Until now, genetic studies have identified…

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