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Abstracts tagged "osteoarthritis and phenotypes"

  • Abstract Number: 288 • 2016 ACR/ARHP Annual Meeting

    Glucose Homeostasis Influences the Risk of Incident Knee Osteoarthritis

    Jeffrey Driban1, Charles B. Eaton2, Mamta Amin3, Alina Stout4, Lori Lyn Price5, Bing Lu6, Grace H. Lo7, Timothy E. McAlindon8 and Mary Barbe9, 1Tufts Medical Center, Boston, MA, 2Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 3Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, 4Rheumatology, Tufts Medical Center, Boston, MA, 5Clinical Care Research, Tufts Medical Center, Boston, MA, 6Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 7Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 8Division of Rheumatology, Tufts Medical Center, Boston, MA, 9Temple University School of Medicine, Philadelphia, PA

    Background/Purpose: Knee osteoarthritis (KOA), particularly accelerated KOA, is associated with older age and being overweight. Greater age and weight are associated with impaired glucose homeostasis…
  • Abstract Number: 298 • 2016 ACR/ARHP Annual Meeting

    Disease Progression in Osteoarthritis Is Driven By Multiple Disease Parameters Leading to Comparable Levels of Joint Destruction

    Anne C. Bay-Jensen1, Asger Bihlet2, Inger Byrjalsen2, Jeppe Andersen3, Christian S. Thudium4, Bente J. Riis2, Claus Christiansen2, Hans Guehring5, Martin Michaelis5, Christoph Ladel5 and Morten Asser Karsdal6, 1Rheumatology, Nordic Bioscience, Biomarkers and Research, Herlev, Denmark, 2Nordic Bioscience, Clinical Development, Herlev, Denmark, 3Clinical Development, Nordic Bioscience, Herlev, Denmark, 4Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 5Merck KGaA, Darmstadt, Germany, 6Rheumatology, Nordic Bioscience, Herlev, Denmark

    Background/Purpose:  There is a need for successful drug development in osteoarthritis (OA) as there are currently no disease modifying drugs approved for OA. This may…
  • Abstract Number: 1020 • 2016 ACR/ARHP Annual Meeting

    Risk Factors Can Classify Individuals Who Develop Accelerated Knee Osteoarthritis

    Jeffrey Driban1, Timothy E. McAlindon2, Mamta Amin3, Lori Lyn Price4, Charles B. Eaton5, Julie Davis6, Bing Lu7, Grace H. Lo8, Jeffrey Duryea9 and Mary Barbe10, 1Tufts Medical Center, Boston, MA, 2Division of Rheumatology, Tufts Medical Center, Boston, MA, 3Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA, 4Clinical Care Research, Tufts Medical Center, Boston, MA, 5Family Medicine and Community Health( Epidemiology), Alpert Medical School of Brown University, Pawtucket, RI, 6Rheumatology, Tufts Medical Center, Boston, MA, 7Brigham & Women's Hospital and Harvard Medical School, Boston, MA, 8Immunology, Allergy, Rheumatology, Baylor College of Medicine, Houston, TX, 9Radiology, Brigham & Women's Hospital/ Harvard Medical School, Boston, MA, 10Temple University School of Medicine, Philadelphia, PA

    Background/Purpose: Accelerated knee osteoarthritis (KOA) is a painful disorder and associated with several risk factors: greater age, greater body mass index (BMI), static knee alignment,…
  • Abstract Number: 2401 • 2015 ACR/ARHP Annual Meeting

    Identification and Characterization of Two Osteoarthritis Phenotypes Applying Two Clinically Tested Biomarkers

    Anne C. Bay-Jensen1, Asger Bihlet2, Inger Byrjalsen3, Bente J. Riis2, Claus Christiansen2, Morten Asser Karsdal1 and Jeppe Andersen2, 1Biomarkers and Research, Nordic Bioscience, Herlev, Denmark, 2Nordic Bioscience, Herlev, Denmark, 3Research & Development, Nordic Bioscience, Herlev, Denmark

    Background/Purpose: The osteoarthritis (OA) population is heterogeneous and it is therefore difficult to target all patients with the same intervention. Thus there is a clinical…
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