Abstracts tagged "osteoarthritis and pain management"

Abstract Number: 267 • 2014 ACR/ARHP Annual Meeting
Selective and Peripheral-Specific Trk Inhibitor Shows Potent Analgesic Effect Comparable to Morphine in Rat Osteoarthritis Model without CNS Toxicity
Takeshi Nagaura¹, Tetsuya Yasuhiro², Keisuke Oda², Yuya Ezaki², Takashi Koyanagi², Satoshi Itadani², Hiroyuki Nitta², Hiroshi Wakazono², Seishi Katsumata² and Yasushi Hirota², ¹Discovery Research Laboratories I, Department of Biology & Pharmacology, Ono Pharmaceutical Co., Ltd., Osaka, Japan, ²Ono Pharmaceutical Co., Ltd., Osaka, Japan
Background/Purpose Tropomyosin receptor kinase (Trk) receptors are a family of three closely related receptor tyrosine kinases; TrkA, TrkB and TrkC. Especially, the peripheral TrkA in…

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Abstracts tagged "osteoarthritis and pain management"

Selective and Peripheral-Specific Trk Inhibitor Shows Potent Analgesic Effect Comparable to Morphine in Rat Osteoarthritis Model without CNS Toxicity