Abstract Number: 2947 • ACR/ARHP Annual Meeting 2017
Do Bone Marrow Lesions Reactivate Endochondral Ossification Leading to Osteophyte Genesis? Data from the Osteoarthritis Initiative
Background/Purpose: Osteophytes are formed through reactivation of endochondral ossification. In adults, reactivation of endochondral ossification may occur in the context of fracture repair. As yet,…Abstract Number: 2793 • ACR/ARHP Annual Meeting 2014
BMP2 Requires TGF-Beta to Induce Osteophytes during Experimental Osteoarthritis
Background/Purpose: Osteophytes are a major hallmark of osteoarthritis (OA). Both TGF-beta and BMP2 can induce osteophytes in murine knee joints. We demonstrated that TGF-beta could…Abstract Number: 71 • ACR/ARHP Annual Meeting 2013
Subchondral Bone Turnover and Osteophyte Formation Are Key Aspects In The Progression Of Osteoarthritis and May Be Assessed and Predicted By a-CTX
Background/Purpose: Osteoarthritis (OA) is the most common form of arthritic disease. It is characterized by pathological changes in both bone and cartilage turnover as well…Abstract Number: 49 • ACR/ARHP Annual Meeting 2013
Chondrocyte-Specific Bone Morphogenetic Protein-2 Overexpression Results In Severe Aggravation Of Osteophyte Formation In Experimental Osteoarthritis Without Altering Cartilage Damage In Young Mice
Background/Purpose: In murine osteoarthritis (OA) models chondrocytes surrounding lesions express elevated levels of Bone Morphogenetic Protein-2 (BMP2). This growth factor is well known for its…Abstract Number: 2515 • ACR/ARHP Annual Meeting 2012
Low Density Lipoprotein Receptor Deficiency Results in Osteophyte Formation During Experimental Osteoarthritis Which Is Enhanced Under High Cholesterol Conditions
Background/Purpose: Synovial macrophages are involved in osteophyte formation during experimental collagenase-induced osteoarthritis (OA). Accumulated LDL can be oxidized in an inflammatory environment such as OA…
ACR Meeting Abstracts