Abstracts tagged "opioids"

Abstract Number: 1880 • 2019 ACR/ARP Annual Meeting
Baricitinib 4 Mg and 2 Mg Once Daily Reduced Pain in Both Patients Who Were Opioid Users and Non-users in Active Rheumatoid Arthritis: A Post-hoc Analysis of Phase 3 Trials
Janet Pope¹, Yvonne Lee ², Jeffrey Curtis ³, Daojun Mo ⁴, Terence Rooney ⁴, Li Xie ⁴, Christina Dickson ⁴, Douglas Schlichting ⁴, Amanda Quebe ⁴, Anabela Cardoso ⁴, Lee Simon ⁵ and Peter Taylor ⁶, ¹Western University, London, ON, Canada, ²Northwestern University Feinberg School of Medicine, Chicago, ³University of Alabama at Birmingham, Birmingham, AL, ⁴Eli Lilly and Company, Indianapolis, IN, ⁵SDG LLC, Cambridge, MA, ⁶University of Oxford, Oxford, United Kingdom
Background/Purpose: Opioid use in RA patients has increased over the past 2 decades in the US. Little is known about the combined effects of opioids…
Abstract Number: 440 • 2018 ACR/ARHP Annual Meeting
Assessing Inappropriate Pain Management in Adults with Hip or Knee Osteoarthritis Treated with Different Opioid Intensity Regimens: Results from a Retrospective Database Analysis
Nathaniel P. Katz^1,2, Kavita Gandhi³, Wenhui Wei⁴, Ahong Huang⁵ and Li Wang⁶, ¹President, Analgesic Solutions, Natick, MA, ²Tufts University School of Medicine, Boston, MA, ³Director, Global Health Economics and Outcomes Research, Teva Pharmaceutical Industries, Frazer, PA, ⁴Senior Director, Health Economics and Outcomes Research (HEOR), Regeneron Pharmaceuticals, Inc., Tarrytown, NY, ⁵Project Manager, STATinMED Research, Dallas, TX, ⁶Senior Director, Analytic Research, STATinMED Research, Dallas, TX
Background/Purpose: Opioids are often prescribed for osteoarthritis (OA) pain management despite the need for balancing their risks and benefits. Since there are no standard criteria…
Abstract Number: 442 • 2018 ACR/ARHP Annual Meeting
Patient Factors Associated with Gaps in Osteoarthritis Care
Lauren King¹, Deborah A. Marshall² and Gillian Hawker³, ¹University of Toronto, Canada, Department of Medicine, University of Toronto, Toronto, ON, Canada, ²Community Health Sciences, University of Calgary, Calgary, AB, Canada, ³Women's College Research Institute/Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Exercise, weight loss, simple analgesic medications and joint injections are effective non-surgical treatments for knee osteoarthritis (OA) to reduce pain and improve function. While…
Abstract Number: 1374 • 2018 ACR/ARHP Annual Meeting
The Relationship between Loneliness and Osteoarthritis in US Adults from a Nationally Representative Survey
Adeela Cheema¹, Louise Hawkley², Kristen Wroblewski³ and Kichul Ko⁴, ¹Section of Geriatrics and Palliative Medicine, Department of Medicine, University of Chicago, Chicago, IL, ²NORC, University of Chicago, Chicago, IL, ³Department of Public Health Sciences, University of Chicago, Chicago, IL, ⁴Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL
Background/Purpose: Loneliness in adults is a growing phenomenon across the Western world. It is associated with increased mortality, depression, coronary heart disease and stroke. Moreover,…
Abstract Number: 1917 • 2018 ACR/ARHP Annual Meeting
Physician Opioid Prescribing Patterns and Risk for Chronic Opioid Use Among Rheumatoid Arthritis Patients
Yvonne C. Lee¹, Bing Lu², Hongshu Guan³, Jeffrey Greenberg⁴, Joel Kremer⁵ and Daniel Solomon⁶, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Rheumatology Immunology & Allergy, Brigham & Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Corrona, LLC, Waltham, MA, ⁵Albany Medical College and The Center for Rheumatology, Albany, NY, ⁶Rheumatology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Experts have implicated physician prescribing rates as a contributing factor to the opioid crisis. However, little is known about heterogeneity in these patterns and…
Abstract Number: 1919 • 2018 ACR/ARHP Annual Meeting
Individual Short-Acting Opioids and the Risk of Opioid-Related Adverse Events in Adolescents
Cecilia P. Chung¹, S. Todd Callahan², William Cooper², William Dupont³, Katherine Murray¹, Andrew Franklin⁴, Kathi Hall⁵, Judith A. Dudley⁵, C. Michael Stein¹ and Wayne Ray⁵, ¹Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Pediatrics, Vanderbilt University Medical Center, Nashville, TN, ³Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ⁴Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, ⁵Health Policy, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Hydrocodone, codeine, oxycodone, and tramadol are frequently prescribed for moderate pain in adolescents. However, pharmacokinetic and pharmacodynamic differences between these short-acting opioids could affect…
Abstract Number: 15L • 2017 ACR/ARHP Annual Meeting
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Titration-to-Effect Study of Orally Administered CR845 in Patients with Osteoarthritis of the Hip or Knee
Sukirti Bagal, Catherine Munera, Patricia Brady and Joseph Stauffer, Cara Therapeutics, Stamford, CT

Background/Purpose: CR845 is a selective kappa opioid receptor agonist with a peripheral mechanism of action. Here we report preliminary results from a Phase 2b study…
Abstract Number: 856 • 2017 ACR/ARHP Annual Meeting
Trends and Predictors of Chronic Opioid Use in Individuals with RA
Yvonne C. Lee¹, Joel Kremer², Hongshu Guan³, Jeffrey D Greenberg⁴ and Daniel H. Solomon⁵, ¹Rheumatology Immunology & Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²The Center for Rheumatology, Albany Medical College, Albany, NY, ³Rheumatology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁴NYU School of Medicine, New York, NY, ⁵Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: The opioid epidemic is a major public health concern, requiring urgent action. However, little is known about chronic opioid use among individuals with RA.…
Abstract Number: 2235 • 2017 ACR/ARHP Annual Meeting
Factors Associated with Opioid Use in End-Stage Knee, Hip and Spine Osteoarthritis
J. Denise Power¹, Anthony V. Perruccio¹, Rajiv Gandhi¹, Christian Veillette¹, J. Roderick Davey¹, Stephen J. Lewis¹, Khalid Syed¹, Nizar Mahomed¹ and Y. Raja Rampersaud², ¹Arthritis Program, Krembil Research Institute, University Health Network, Toronto, ON, Canada, ²Arthritis Program, Krembil Research Institute, University Health Network, Torotno, ON, Canada
Background/Purpose: The use of prescription opioids has been under increasing scrutiny due to concerns about the potential for misuse, dependency and increased adverse events. The…
Abstract Number: 467 • 2017 ACR/ARHP Annual Meeting
Smoking and Opioid Use Is Associated with Symptom Severity in Rheumatoid Arthritis
Angela Karellis^1,2, Emmanouil Rampakakis³, John S. Sampalis^1,4, Martin Cohen⁵, Michael Starr⁵, Peter Ste-Marie⁶, Yoram Shir⁶, Mark Ware⁶ and MaryAnn FitzCharles^6,7, ¹JSS Medical Research, St-Laurent, QC, Canada, ²Department of Surgery, McGill University, Montreal, QC, Canada, ³JSS Medical Research, Montreal, QC, Canada, ⁴McGill University, Montreal, QC, Canada, ⁵Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁶Alan Edwards Pain Management Unit, McGill University Health Centre, Montreal, QC, Canada, ⁷Rheumatology, McGill University, Montreal, QC, Canada
Smoking and Opioid Use Is Associated with Symptom Severity in Rheumatoid ArthritisBackground/Purpose: Cigarette smoking, both current and past, is a risk for incident rheumatoid arthritis…
Abstract Number: 369 • 2016 ACR/ARHP Annual Meeting
Opioid Prescriptions and Adverse Reactions in Children and Adolescents without Serious Diseases
Cecilia P. Chung¹, S. Todd Callahan², William Cooper², William Dupont³, Katherine Murray¹, Kathi Hall⁴, Judith A. Dudley⁴, C. Michael Stein¹ and Wayne Ray⁴, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Pediatrics, Vanderbilt University Medical Center, Nashville, TN, ³Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ⁴Health Policy, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: There is a well-described epidemic of deaths and hospitalizations related to opioid prescriptions in adults. However, little is known about opioid toxicity in children.…
Abstract Number: 995 • 2016 ACR/ARHP Annual Meeting
Use of Opiate Diminished the Treatment Benefits of Motivational Interviewing for Fibromyalgia
Dennis Ang¹ and James Slaven², ¹Wake Forest University, Winston-Salem, NC, ²Biostatistics, Indiana University, Indianapolis, IN
Background/Purpose: Opiate is not indicated in the treatment of fibromyalgia (FM). In fact, chronic use of opiate may even worsen the symptoms of fibromyalgia. There…
Abstract Number: 1982 • 2016 ACR/ARHP Annual Meeting
Comparative Safety of Long-Acting Opioids for Non-Cancer Pain
Cecilia P. Chung¹, William Dupont², Katherine Murray¹, Kathi Hall³, C. Michael Stein¹ and Wayne Ray³, ¹Medicine, Vanderbilt University Medical Center, Nashville, TN, ²Biostatistics, Vanderbilt University Medical Center, Nashville, TN, ³Health Policy, Vanderbilt University Medical Center, Nashville, TN
Background/Purpose: Methods: Results: Conclusion:
Abstract Number: 2186 • 2016 ACR/ARHP Annual Meeting
Analgesic Use and Subsequent Risk of Falls in Participants with or at Risk of Knee Osteoarthritis
Wei-Hsuan Lo-Ciganic¹, Lysbeth Floden², Erin L. Ashbeck³, Lili Zhou¹ and C. Kent Kwoh^3,4, ¹Department of Pharmacy, Practice and Science, University of Arizona, College of Pharmacy, Tucson, AZ, ²Department Pharmacy, Practice and Science, University of Arizona, College of Pharmacy, Tucson, AZ, ³The University of Arizona Arthritis Center, Tucson, AZ, ⁴Rheumatology, University of Arizona, College of Medicine, Tucson, AZ
Background/Purpose: Analgesics including opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, and nutraceuticals are commonly used for pain relief in osteoarthritis (OA). Although it has been reported…
Abstract Number: 3003 • 2016 ACR/ARHP Annual Meeting
Impact of Preoperative Opioid Use on Total Knee Arthroplasty Outcomes
Savannah R. Smith¹, Heidi Y. Yang², Jamie E. Collins³, Jeffrey N. Katz⁴ and Elena Losina⁵, ¹Orthopedic and Arthritis Center for Outcomes Research, Brigham and Women's Hospital, Boston, MA, ²Orthopaedic and Arthritis Center for Outcomes Research, Brigham & Women's Hospital, Boston, MA, ³Orthopaedic and Arthritis Center for Outcomes Research, Department of Orthopedic Surgery, Brigham & Women's Hospital, Boston, MA, ⁴Orthopaedics, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Orthopaedics, Brigham & Women's Hospital, Boston, MA
Background/Purpose: Total knee arthroplasty (TKA) is an effective treatment for patients with end-stage knee osteoarthritis (OA); however, a growing body of evidence suggests that patients…

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