ACR Meeting Abstracts

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Abstracts tagged "Oncology"

  • Abstract Number: 1728 • ACR Convergence 2024

    Higher Oral Steroid Dose Is Associated with Worse Survival in Immune Checkpoint Inhibitor-Treated Rheumatoid Arthritis Patients with Metastatic Non-Small Cell Lung Cancer

    Deanna Jannat-Khah1, Jeffrey Curtis2, Fenglong Xie3, Ashish Saxena4 and Anne Bass5, 1Hospital For Special Surgery, New York, NY, 2The University of Alabama at Birmingham, Birmingham, AL, 3University of Alabama at Birmingham, Birmingham, AL, 4Weill Cornell Medicine, New York, NY, 5Hospital for Special Surgery, Weill Cornell Medicine, New York, NY

    Background/Purpose: It is unknown if steroid use for RA patients could interfere with the benefits of immune checkpoint inhibitors (ICI) as cancer therapies. Additionally, it…
  • Abstract Number: 1894 • ACR Convergence 2024

    Detection of Fibrotic Lung Changes and Bronchiectasis in RA Patients Screened for Lung Cancer with Low-dose CT Chest: Results from a Large Multi-hospital System

    Gregory McDermott1, Mark Hammer2, Xiaosong Wang3, Misti Paudel4, Sung Hae Chang5, Pierre-Antoine Juge6, Qianru Zhang7, Jessica Lorusso8, Amie Samulyov8, Kathleen Vanni2, Alene Saavedra2, Emily Kowalski2, Grace Qian3, Katarina Bade2, Kevin Mueller2, Jeffrey Sparks9 and Suzanne Byrne2, 1Brigham and Women's Hospital, Brookline, MA, 2Brigham and Women's Hospital, Boston, MA, 3Brigham and Women’s Hospital, Boston, MA, 4Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 5Soonchunhyang University College of Medicine, Bongmyeong-dong, Dongnam-gu, Cheonan-si, South Korea, 6Departement of Rheumatology, AP-HP, Bichat Hospital, Boston, MA, 7Harard Medical School, Cambridge, 8Mass General Brigham, Boston, MA, 9Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA

    Background/Purpose: Cigarette smoking is a risk factor for both lung cancer and RA. Furthermore, RA is associated with pulmonary abnormalities including interstitial lung disease, bronchiectasis,…
  • Abstract Number: 1979 • ACR Convergence 2024

    Safety and Effectiveness of Immune Checkpoint Inhibitor Therapy in Patients with Pre-existing Autoimmune Disease

    Siddhartha Goutam1, Arjun athreya Raghavan2, Carrie Ye3, Liam O'Neil4 and Jeffrey Graham1, 1Max Rady School of Medicine, University of Manitoba, Winnipeg, MB, Canada, 2University of Manitoba Max Rady College of Medicine, Winnipeg, MB, Canada, 3Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Immune checkpoint inhibitors (ICI) have altered the treatment landscape within oncology, with an expanding number of indications. Patients with pre-existing autoimmune disease (PAD) have…
  • Abstract Number: 0010 • ACR Convergence 2024

    Precision Editing of Cyclophilin a to Engineer Cyclosporine- and Voclosporin- Resistant Human CAR-T Cells

    Holly Wobma1, Francesca Alvarez-Calderon2, Jiayi Dong2, Alexandre Albanese2, Kayleigh Omdahl2, Rene Bermea3, Gillian Selig4, Marlana Winschel2, Elisa Rojas Palato2, Katherine Michaelis1, Xianliang Rui2, Bruce Blazar5, Susan Prockop2, Victor Tkachev3, Ulrike Gerdemann2 and Leslie Kean2, 1Division of Immunology, Boston Children's Hospital, Boston, MA, 2Division of Hematology-Oncology, Boston Children's Hospital, Boston, MA, 3Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 4Harvard College, Boston, MA, 5Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy, University of Minnesota, Minneapolis, MN

    Background/Purpose: With exponential demand for chimeric antigen receptor (CAR) therapies for autoimmune disease, allogeneic options will be essential. Advantages include use of healthy donor cells,…
  • Abstract Number: 1983 • ACR Convergence 2024

    Immune Checkpoint Inhibitor Associated Vasculitis and Polymyalgia Rheumatica: A Systematic Review

    Aaron Teel1, Adrian Grebowicz2, Mats Junek3, Stephanie Garner4, Tom Appleton5 and Faiza Khokhar6, 1London Health Sciences Centre, Sarnia, ON, Canada, 2Western University, London, ON, Canada, 3McMaster University, Hamilton, ON, Canada, 4University of Calgary, Calgary, AB, Canada, 5The University of Western Ontario, London, ON, Canada, 6McMaster University, St. Joseph's Hamilton, Mississauga, ON, Canada

    Background/Purpose: Immune checkpoint inhibitors (ICIs) are a class of cancer immunotherapy that have been associated with immune-related adverse events (irAEs). These include multiple rheumatic diseases…
  • Abstract Number: 0202 • ACR Convergence 2024

    Survival in Patients with Rheumatoid Arthritis and Early-Stage Colorectal, Lung, or Prostate Cancer Receiving Tumor Necrosis Factor Alpha Inhibitors

    Maria Suarez-Almazor1, Juan Ruiz2, Xiudong Lei1, Hui Zhao1, Suja Rajan3, Heather Lin1 and Sharon Giordano1, 1MD Anderson Cancer Center, Houston, TX, 2MD Anderson, Houston, TX, 3The University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: There is concern about the use of tumor necrosis factor inhibitors (TNFi) in patients with early cancer given their immunosuppressant effects. Few studies have…
  • Abstract Number: 1986 • ACR Convergence 2024

    Disease Flare Following Immune Checkpoint Inhibition in Patients with Cancer and Preexisting Vasculitis

    Juan Sevillano1, Yixuan Zhou2, Juan Ruiz3, Noha Abdel-Wahab4 and Maria Suarez-Almazor1, 1MD Anderson Cancer Center, Houston, TX, 2Baylor College of Medicine, Houston, 3MD Anderson, Houston, TX, 4University of Texas MD Anderson Cancer Center, houston, TX

    Background/Purpose: Immune checkpoint inhibitors (ICI) are effective therapies for patients with cancer, but they often cause immune-related adverse events (irAE). There is limited data on…
  • Abstract Number: 0474 • ACR Convergence 2024

    Association Between Rheumatoid Arthritis and Survival After Cancer: A Systematic Literature Review and Meta-analysis

    Joshua Hsieh1, Avneet Kaur2, Hemant Khandelia3, Teresa Jewell4, Aman Singh5, Lauren Barkley6, Ishan Bansal7, Simmi Oberoi8 and Namrata Singh9, 1Lakeside High School, Seattle, WA, 2SUNY Upstate, Buffalo, NY, 3AIIMS, New Delhi, Delhi, India, 4University of Washington, Seattle, WA, 5Rajindra Hospital, Patiala, Punjab, India, 6Brandeis University, Boston, MA, 7Yale University, New Haven, CT, 8Rajindra Hospital, New Delhi, India, 9University of Washington, Bellevue, WA

    Background/Purpose: Increasing evidence suggests that inflammation, a hallmark of rheumatoid arthritis (RA), is associated with an elevated risk of cancer and can influence cancer outcomes.…
  • Abstract Number: 2004 • ACR Convergence 2024

    Rheumatic Complications Post-CAR-T Cell Therapy. Experience of a Single Center

    Jose Alfredo Gomez-Puerta1, Ana Monegal1, Andrés Ponce2, Pilar Peris3, Nuria Martínez4, Valentin Ortiz-Maldonado4, Ana Triguero4, Carlos Fernández de larrea4, Julio Delgado4, Raimon Sanmartí Sala1 and Manuel Juan5, 1Rheumatology Department, Hospital Clinic of Barcelona, Barcelona, Spain, 2Rheumatology Department, Hospital Clínic of Barcelona, Barcelona, Spain, 3Rheumatology Department, Hospital Clínic de Barcelona, Barcelona, Spain, 4Haematology Department, Hospital Clinic of Barcelona, Barcelona, Spain, 5Immunology Department, Hospital Clinic of Barcelona, Barcelona, Spain

    Background/Purpose: CAR-T cell therapy is a promising treatment for a range of systemic autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, and antisynthetase syndrome,…
  • Abstract Number: 0486 • ACR Convergence 2024

    Associations Between Frailty and Incident Cancer and Cancer-related Mortality in Veterans with Rheumatoid Arthritis

    Bhavik Bansal1, Aaron Baraff2, Katherine Wysham3, James Andrews4, Bryant England5, Ted Mikuls5, Joshua Baker6, Kaleb Michaud5, Alexa Meara7, Una Makris8, Carolyn Presley9, ariela orkaby10 and Namrata Singh11, 1All India Institute of Medical Sciences, New Delhi, Delhi, India, 2VA PUGET SOUND SEATTLE, Seattle, WA, 3VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Nebraska Medical Center, Omaha, NE, 6University of Pennsylvania, Philadelphia, PA, 7The Ohio State University Wexner Medical Center, COLUMBUS, OH, 8UT Southwestern Medical Center and Dallas VA, Dallas, TX, 9The Ohio State Medical Center, Columbus, OH, 10New England VA Geriatric Research Education and Clinical Center/Boston VA/Division of Aging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 11University of Washington, Bellevue, WA

    Background/Purpose: Rheumatoid arthritis (RA) is associated with an increased risk of cancer compared to the general population. Aging is one of the most important risk…
  • Abstract Number: 2117 • ACR Convergence 2024

    The Risk of Medication-related Osteonecrosis of the Jaw (MRONJ) in a Patient with Osteoporosis Treated with Antiresorptive Therapy and Undergoing Dental Care Is Negligible with a CTX Threshold Above 260

    Camille Ghio, Robinson Gravier-Dumonceau, Pierre Lafforgue, Roch Giorgi and Thao Pham, Assistance Publique-Hôpitaux de Marseille, Marseille, France

    Background/Purpose: Although antiresorptive treatments, including bisphosphonates and denosumab, have demonstrated their efficacy in treating osteoporosis. However, osteonecrosis of the jaw has been reported as a…
  • Abstract Number: 0916 • ACR Convergence 2024

    Isocitrate Dehydrogenase 2 Mutations Are Associated with Autoimmune Rheumatologic Diseases in Chronic Myelomonocytic Leukemia

    Mahmut Kaymakci1, Anuya Natu2, Clifford Csizmar2, Terra Lasho2, Christy Finke2, Abhishek Mangaonkar1, Aref Al-Kali1, Hassan Alkhateeb1, Jenna Fernandez2, Matthew Koster1, Cornelia Weyand2, Mrinal Patnaik1 and Kenneth Warrington1, 1Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester

    Background/Purpose: Somatic mutations occurring in the hematopoietic system can be associated with concomitant hematologic and inflammatory diseases. Chronic myelomonocytic leukemia (CMML) is a hematologic neoplasm…
  • Abstract Number: 2287 • ACR Convergence 2024

    Hydroxychloroquine and the Risk of Lymphoma Progression in Sjogren’s Disease: A Retrospective Case Control Study

    Christine Xue1, Monica Guma2 and Katherine Nguyen2, 1UC San Diego, San Diego, CA, 2UC San Diego, San Diego

    Background/Purpose:  Sjogren's disease is an autoimmune disorder characterized by chronic lymphocytic inflammation of the salivary and lacrimal glands. Affected individuals are at heightened risk of…
  • Abstract Number: 0989 • ACR Convergence 2024

    Malignancy Risk Between JAK Inhibitors and Anti-TNF Therapy Across Disease Indications: A Bayesian Network Meta-analysis

    Mark Gibson1, Benjamin Zuckerman2, Maryam Adas1, Mark Russell3, Katie Bechman1 and James Galloway4, 1King's College London, London, United Kingdom, 2King's College London, London, England, United Kingdom, 3King's College London, London, United Kingdom, 4Centre for Rheumatic Diseases, King's College London, London, United Kingdom

    Background/Purpose: To estimate the relative risk of malignancy between Janus kinase inhibitors (JAKi), tumour necrosis factor-α inhibitors (TNFi) and placebo in individuals with immune-mediated inflammatory…
  • Abstract Number: 1155 • ACR Convergence 2024

    Stratification of Cancer Risk in Idiopathic Inflammatory Myopathies. Application of the IMACS Guidelines to Enhance Screening

    Miriam Retuerto Guerrero1, Clara Moriano2, cristiana sieiro santos3 and elvira Diez álvarez4, 1Complejo Asistencial Universitario de León, Leon, Spain, 2Hospital León, LEON, Spain, 3Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, 4Complejo Asistencial Universitario de Leon, Leon

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) carry an elevated risk of cancer incidence. Recently published International Guidelines for IIM-associated cancer screening from the Myositis Assessment and…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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