ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "OA and chondrocytes"

  • Abstract Number: 55 • 2017 ACR/ARHP Annual Meeting

    Nrf2 Inhibits Apoptosis and Suppresses Oxidative Stress By Activating NOX4/ERK1/2/ELK1 Signaling Axis in Human Chondrocytes

    Mohammad N. Khan1, Imran Ahmad1, Mohammad Y Ansari2 and Tariq M Haqqi1, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH

    Background/Purpose: Nrf2 is a redox sensitive transcription factor that regulates the expression of phase II antioxidant enzymes and cytoprotective genes and is crucial for maintaining…
  • Abstract Number: 1137 • 2015 ACR/ARHP Annual Meeting

    Low Molecular Weight Polyphenol Harpagoside Inhibits IL-1β-Induced Expression of IL-6 By Blocking the Expression and Activity of c-Fos in Primary Human Osteoarthritis Chondrocytes

    Abdul Haseeb1,2, Mohammad Ansari3 and Tariq Haqqi1, 1Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, 3Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH

    Background/Purpose: Osteoarthritis (OA) is a multifactorial disease and is characterized by focal degradation of articular cartilage. Several components of the inflammatory pathway, such as IL-6,…
  • Abstract Number: 1134 • 2015 ACR/ARHP Annual Meeting

    Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing

    Mohammad Shahidul Makki1 and Tariq Haqqi2, 14209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, 2Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH

    Background/Purpose:  Osteoarthritis (OA) is a chronic and debilitating disease of articulating joints. Mechanical stress, genetic and environmental factors play critical role in the pathogenesis of…
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