Abstracts tagged "OA and chondrocytes"

Abstract Number: 55 • 2017 ACR/ARHP Annual Meeting
Nrf2 Inhibits Apoptosis and Suppresses Oxidative Stress By Activating NOX4/ERK1/2/ELK1 Signaling Axis in Human Chondrocytes
Mohammad N. Khan¹, Imran Ahmad¹, Mohammad Y Ansari² and Tariq M Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH
Background/Purpose: Nrf2 is a redox sensitive transcription factor that regulates the expression of phase II antioxidant enzymes and cytoprotective genes and is crucial for maintaining…
Abstract Number: 1137 • 2015 ACR/ARHP Annual Meeting
Low Molecular Weight Polyphenol Harpagoside Inhibits IL-1β-Induced Expression of IL-6 By Blocking the Expression and Activity of c-Fos in Primary Human Osteoarthritis Chondrocytes
Abdul Haseeb^1,2, Mohammad Ansari³ and Tariq Haqqi¹, ¹Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy and Neurobiology, Northeast Ohio Medical University (NEOMED), Rootstown, OH, ³Anatomy & Neurobiology, Northeast Ohio Medical University, Roostown, OH
Background/Purpose: Osteoarthritis (OA) is a multifactorial disease and is characterized by focal degradation of articular cartilage. Several components of the inflammatory pathway, such as IL-6,…
Abstract Number: 1134 • 2015 ACR/ARHP Annual Meeting
Identification of Novel Micro-RNAs in IL-1β-Stimulated OA Chondrocytes By Next-Generation Sequencing
Mohammad Shahidul Makki¹ and Tariq Haqqi², ¹4209 St Rt 44 PO Box 95, Northeast Ohio Medical University, Rootstown, OH, ²Anatomy & Neurobiology, Northeast Ohio Medical University, Rootstown, OH
Background/Purpose: Osteoarthritis (OA) is a chronic and debilitating disease of articulating joints. Mechanical stress, genetic and environmental factors play critical role in the pathogenesis of…