Abstracts tagged "Nonsteroidal antiinflammatory drugs (NSAIDs)"

Abstract Number: 0728 • ACR Convergence 2021
Intra-articular Canakinumab (anti-interleukin-1β) for Treatment of Symptomatic Knee Osteoarthritis: A Randomized, Double-blind, Placebo and Naproxen-controlled Phase II Study
Philip Conaghan¹, Xavier Chevalier², Linda Mindeholm³, Ursula Schramm³, Jens Praestgaard³, Abdelkader Seroutou³, Ronenn Roubenoff³ and Matthias Schieker³, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, ²Henri Mondor University Hospital and Paris University XII, UPEC, Créteil, France, Créteil, France, ³Novartis Institutes for Biomedical Research, Basel, Switzerland, Basel, Switzerland
Background/Purpose: Knee osteoarthritis (OA) is a common musculoskeletal disease associated with pain and functional impairment. There are few effective therapies, often limited by side-effects.1 This…
Abstract Number: 1326 • ACR Convergence 2020
Malignancy Risk Among Patients with Ankylosing Spondylitis in the United States: A Population-Based National Study
Sali Merjanah¹, Mohamad Bittar² and Marina Magrey³, ¹Case Western Reserve University, MetroHealth Medical Center, Cleveland, OH, ²The University of Tennessee Health Science Center, Memphis, TN, ³Case Western Reserve University School of Medicine, Cleveland, OH
Background/Purpose: Increased cancer risk has been reported with Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE), but the correlation is poorly studied in Ankylosing spondylitis…
Abstract Number: 1375 • ACR Convergence 2020
Remission in Axial Spondyloarthritis: Is There a Difference Between NSAIDs and Biologics in the Real Life?
Charlotte Baert¹, Charlene Mouafo Toukam², Tatiana Sokolova³, Maria S. Stoenoiu⁴, Patrick Durez⁵, Laurent Meric De Bellefon² and Adrien Nzeusseu Toukap⁶, ¹Rheumatology department, St-Luc university hospitals, Brussels, Belgium, ²Rheumatology department; St-Luc University Hospitals, Brussels, Belgium, ³Rheumatology, Cliniques Universitaires Saint-Luc – Université catholique de Louvain (UCL) – Institut de Recherche Expérimentale et Clinique (IREC), Brussels, Belgium, ⁴1Department of Rheumatology, Cliniques Universitaires Saint-Luc, 2Institut de recherche expérimentale et cliniques (IREC), Brussels, Belgium, ⁵Division of Rheumatology, Cliniques Universitaires Saint-Luc, Bruxelles, Belgium, ⁶1Department of Rheumatology, Cliniques Universitaires Saint Luc, 2Institut de recherche expérimentale et clinique (IREC), Brussels, Belgium
Background/Purpose: Randomized-controlled trials (RCTs) done in axial spondyloarthritis (AxSpA) patients have shown that remission in Ankylosing Spondylitis and nonradiographic AxSpA patients treated without biologics (BIOL)…
Abstract Number: 1635 • ACR Convergence 2020
Profile of Topical Diclofenac Sodium Gel 1% (Voltaren®) Users in a United States Longitudinal Electronic Health Records Database
Amy Kenneally¹, Frédérique Bariguian², Richard Petruschke¹, Arlene Tave³, Jess Edison⁴, Nicholas M. Sicignano⁵ and Francis Barbone¹, ¹GSK Consumer Healthcare, Warren, NJ, ²GSK Consumer Healthcare S.A., Nyon, Switzerland, ³PharmaLex US Corporation, Fairfax, VA, ⁴Walter Reed National Military Medical Center, Bethesda, ⁵Health ResearchTx LLC., Prevose, PA
Background/Purpose: Diclofenac sodium gel 1% (DSG), a topical non-steroidal anti-inflammatory drug (NSAID), is effective for the relief of osteoarthritis (OA) pain in the elbows, wrists,…
Abstract Number: 1646 • ACR Convergence 2020
Use of Prescription Nonsteroidal Anti-inflammatory Drugs (NSAIDs) in Adults with Hip/Knee Osteoarthritis (OA) at Increased Risk for NSAID-related Adverse Events
Jayeshkumar Patel¹, Wenhui Wei², Raveendhara Bannuru³, Ravi Iyer⁴, Nazneen Fatima Shaikh¹, Traci LeMasters¹, Chibuzo Iloabuchi¹, Degang Wang² and Usha Sambamoorthi¹, ¹West Virginia University School of Pharmacy, Morgantown, WV, ²Regeneron Pharmaceuticals, Tarrytown, NY, ³Tufts Medical Center, Boston, MA, ⁴Teva Pharmaceutical Industries, West Chester, PA
Background/Purpose: NSAIDs are commonly used for OA pain, but the benefits of pain relief must be carefully weighed against the potential risk for gastrointestinal (GI),…
Abstract Number: 1852 • ACR Convergence 2020
Intestinal Permeability in the Adjuvant Induced Arthritis Model: Preliminary Study and Impact of NSAIDs
Sophie Hecquet¹, Romain Bordy², Clement Prati¹, Daniel Wendling³, Céline Demougeot² and Frank Verhoeven¹, ¹Rheumatology, University Teaching Hospital, Besançon, France, ²EA4267 Laboratory, Besançon, France, ³CHU Besançon, department of rheumatology, Besancon, France
Background/Purpose: The gut is no longer considered as a simple element associated with spondyloarthritis but as a real actor of the disease. In patients with…
Abstract Number: 1873 • ACR Convergence 2020
The Changing Profile of Ankylosing Spondylitis in the Biologic Era
Lauren Ridley¹, Michael Weisman², Lianne Gensler³, Michael Ward⁴, Mark Hwang⁵, Amirali Tahanan⁶, MinJae Lee⁷, Mohammad Rahbar⁶, Mariko Ishimori⁸, Matthew Brown⁹ and John Reveille¹⁰, ¹McGovern Medical School at UTHealth, Houston, TX, ²Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³University of California San Francisco, San Francisco, CA, ⁴National Institutes of Health, Bethesda, MD, ⁵McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, ⁶McGovern Medical School at UTHealth, Houston, ⁷UT Southwestern, Dallas, ⁸Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Guy's and St Thomas, NHS Foundation Trust and King's College London NIHR Biomedical Research Centre, King's College London, London, United Kingdom, London, United Kingdom, ¹⁰Department of Internal Medicine, University of Texas, Houston, TX
Background/Purpose: To compare disease characteristics, comorbidities, and medication utilization of 573 patients with ankylosing spondylitis (AS) with short (< 20 years) disease duration (from symptom…
Abstract Number: 2023 • ACR Convergence 2020
Efficacy and Safety of Upadacitinib in Patients with Active Ankylosing Spondylitis: 1-Year Results from a Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Extension
Atul Deodhar¹, Désirée van der Heijde², Joachim Sieper³, Filip Van den Bosch⁴, Walter Maksymowych⁵, Tae-Hwan Kim⁶, Mitsumasa Kishimoto⁷, Andrew Östör⁸, Bernard Combe⁹, Yunxia Sui¹⁰, Xin Wang¹⁰, Alvina D. Chu¹¹ and In-Ho Song¹⁰, ¹Oregon Health & Science University, Portland, OR, ²Leiden University Medical Center, Leiden, Netherlands, ³Charité Universitätsmedizin Berlin, Berlin, Germany, ⁴Ghent University Hospital, Ghent, Belgium, ⁵University of Alberta, Edmonton, AB, Canada, ⁶Hanyang University Hospital for Rheumatic Diseases, Seoul, Seoul-t'ukpyolsi, Republic of Korea, ⁷Department Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ⁸Cabrini Medical Center, Monash University, Malvern, Victoria, Australia, ⁹University of Montpellier, Montpellier, France, ¹⁰AbbVie Inc., North Chicago, IL, ¹¹AbbVie, North Chicago, IL
Background/Purpose: Upadacitinib (UPA), a Janus kinase (JAK) inhibitor, was efficacious and well tolerated vs placebo (PBO) during the first 14 weeks (wks) of the phase…
Abstract Number: 1097 • 2019 ACR/ARP Annual Meeting
Trends in NSAIDs and Opioids Among Patients with SLE: A Population-based Study
Lingyi Li¹, Na Lu ¹, Jacek Kopec ², John Esdaile ³, Hui Xie ⁴ and J. Antonio Avina-Zubieta ², ¹Arthritis Research Canada, Vancouver, BC, Canada, ²Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada, ³Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁴Arthritis Research Canada and Simon Fraser University, Vancouver, BC, Canada
Background/Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are prescribed for the management of pain among patients with rheumatic diseases including systemic lupus erythematosus (SLE). However,…
Abstract Number: 2195 • 2019 ACR/ARP Annual Meeting
BMI Has Minimal Effect on Reduction of Symptoms in Patients with Osteoarthritis of the Knee Treated with Diclofenac 1% Gel
Joel A. Block¹, Bharat Patel ² and Sandy Yacoub Garas ³, ¹Rush University Medical Center, Chicago, IL, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ
Background/Purpose: Clinical trials demonstrate that diclofenac sodium gel 1% (DSG 1%), a topical NSAID, provides significantly better pain relief than vehicle placebo for patients with…
Abstract Number: 2197 • 2019 ACR/ARP Annual Meeting
Clinically Relevant Improvements in Knee Osteoarthritis Pain with Diclofenac Sodium Gel 1%
Marc C. Hochberg¹, Bharat Patel ², Sandy Yacoub Garas ³ and Roy Altman ⁴, ¹University of Maryland School of Medicine, Baltimore, MD, ²GlaxoSmithKline Consumer Healthcare, Weybridge, United Kingdom, ³GlaxoSmithKline Consumer Healthcare, Warren, NJ, ⁴University of California, Los Angeles
Background/Purpose: Topical agents are recommended for the initial treatment of patients with knee osteoarthritis (OA). Diclofenac sodium gel 1% (DSG 1%), a topical nonsteroidal anti-inflammatory…
Abstract Number: 2880 • 2019 ACR/ARP Annual Meeting
Secukinumab Improves Axial Manifestations in Patients with Psoriatic Arthritis and Inadequate Response to NSAIDs: Primary Analysis of Phase 3 Trial
Xenofon Baraliakos¹, Laura Coates ², Laure Gossec ³, Slawomir Jeka ⁴, Antonio Mera ⁵, Barbara Schulz ⁶, Michael Rissler ⁶, Ayan Das Gupta ⁷, Chiara Perella ⁶ and Effie Pournara ⁸, ¹Rheumatology Department, Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Bochum, Germany, ²University of Oxford, Oxford, United Kingdom, ³Sorbonne Université and Hôpital Pitié-Salpêtrière, Paris, France, ⁴University Hospital Bydgoszcz no 2, CM UMK, Bydgoszcz, Poland, ⁵Division of Rheumatology, Instituto de Investigación Sanitaria-Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain, Santiago de Compostela, Spain, ⁶Novartis Pharma AG, Basel, Switzerland, ⁷Novartis Healthcare Pvt Ltd, Hyderabad, India, ⁸Novartis Pharma AG, Basel, Basel-Stadt, Switzerland
Background/Purpose: Secukinumab (SEC) has provided significant and sustained improvement in the signs and symptoms of active psoriatic arthritis (PsA) and ankylosing spondylitis1. Evidence is limited…
Abstract Number: 2891 • 2019 ACR/ARP Annual Meeting
Cost-effectiveness of Duloxetine for Knee OA Patients Whose Pain Can’t Be Controlled by NSAIDs
James Sullivan¹, Jeffrey Katz ² and Elena Losina ³, ¹Brigham and Women's Hospital, Boston, ²Brigham and Women's Hospital/Harvard Medical School, Boston, ³Brigham and Women's Hospital and Harvard Medical School, Boston, MA
Background/Purpose: Knee OA is a disabling condition affecting over 14 million adults in the US. NSAIDs provide only short-term pain relief, creating the need for…
Abstract Number: 2952 • 2018 ACR/ARHP Annual Meeting
Major NSAID Toxicity: Derivation and Internal Validation of a Simple Clinical Risk Score
Daniel Solomon¹, Ming Shao², Katherine E Wolski³, Steven E Nissen⁴, M. Elaine Husni⁵ and Nina Paynter⁶, ¹Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ²Cleveland Clinic Foundation, Cleveland, OH, ³Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, ⁴Cardiovascular Medicine, Chair, Cleveland Clinic, Cleveland, OH, ⁵Orthopedic and Rheumatologic Institute, Cleveland Clinic, Cleveland, OH, ⁶Medicine, Harvard University, Boston, MA
Background/Purpose: NSAIDs and Coxibs represent one of the most commonly prescribed drugs by rheumatologists and are used regularly by >10 million Americans. While most patients…
Abstract Number: 895 • 2018 ACR/ARHP Annual Meeting
Associations of Statin Usage with Disease Activity in Ankylosing Spondylitis
Jonathan Dau¹, Lianne S. Gensler², MinJae Lee³, Michael Ward⁴, Matthew Brown⁵, Laura A. Diekman⁶, Mohammad H. Rahbar⁷, Mariko Ishimori⁸, Michael Weisman⁹ and John D. Reveille¹⁰, ¹McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, TX, ²University of California San Francisco, San Francisco, CA, ³Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, University of Texas-McGovern Medical School, Houston, TX, ⁴National Institutes of Health, Bethesda, MD, USA, Bethesda, MD, ⁵Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Translational Research Institute, Brisbane, Australia, Brisbane, Australia, ⁶Rheumatology, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁷Biostatistics/Epidemiology/Research Design (BERD) Core | Center for Clinical and Translational Sciences, McGovern Medical School at the University of Texas Health Science Center at Houston, USA, Houston, TX, ⁸Medicine, Division of Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ⁹Rheumatology, Cedars-Sinai Medical Center, Los Angeles, CA, ¹⁰McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX
Background/Purpose: Recent studies have shown possible anti-inflammatory effects and a survival benefit with statin usage in ankylosing spondylitis (AS). The purpose of this study was…

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