Abstracts tagged "non-radiographic and tumor necrosis factor (TNF)"

Abstract Number: 1507 • ACR/ARHP Annual Meeting 2017
Comparison of the Clinical and Imaging Arms of the Assessment of Spondyloarthritis International Society Classification Criteria and Parameters of Objective Inflammation in Patients with Non-Radiographic Axial Spondyloarthritis
Robert B.M. Landewé¹, Joachim Sieper², Atul A. Deodhar³, Helena Marzo-Ortega⁴, Robert G. Lambert⁵, Mei Li⁶, Xin Wang⁶ and Jaclyn K. Anderson⁶, ¹University of Amsterdam, Amsterdam, Netherlands, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Oregon Health & Science University, Portland, OR, ⁴NIHR LBRC, Leeds Teaching Hospitals Trust and LIRMM, University of Leeds, Leeds, United Kingdom, ⁵University of Alberta, Edmonton, AB, Canada, ⁶AbbVie Inc., North Chicago, IL
Background/Purpose: Assessment of SpondyloArthritis international Society (ASAS) recommendations for use of TNF inhibitors (TNFi) in axial SpA include active disease and a positive expert opinion,…
Abstract Number: 1787 • ACR/ARHP Annual Meeting 2017
Efficacy and Safety of Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Patients with Non-Radiographic Axial Spondyloarthritis
Robert B.M. Landewé¹, Joachim Sieper², Philip J Mease³, Robert D Inman⁴, Xin Wang⁵, Mei Li⁵, Aileen L. Pangan⁵ and Jaclyn K. Anderson⁵, ¹University of Amsterdam, Amsterdam, Netherlands, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Swedish Medical Center and University of Washington, Seattle, WA, ⁴Department of Immunology, University of Toronto, Toronto, ON, Canada, ⁵AbbVie Inc., North Chicago, IL
Background/Purpose: It is not known whether TNF blockers can be stopped in non-radiographic (nr-axSpA) patients who are in remission. In ABILITY-1, adalimumab (ADA) significantly improved…
Abstract Number: 2501 • ACR/ARHP Annual Meeting 2017
Potential Differences in Axial Spondyloarthritis Disease Activity Categorization Using Different Minimum Values for High-Sensitivity CRP in Ankylosing Spondylitis Disease Activity Score Calculation and Different Definitions of Disease Flare
Robert B.M. Landewé¹, Joachim Sieper², Uta Kiltz³, Xin Wang⁴, Mei Li⁴ and Jaclyn K. Anderson⁴, ¹University of Amsterdam, Amsterdam, Netherlands, ²Charité Universitätsmedizin Berlin, Berlin, Germany, ³Rheumazentrum Ruhrgebiet, Herne, Germany, ⁴AbbVie Inc., North Chicago, IL
Background/Purpose: It has been recommended that the lower limit of high-sensitivity CRP (hsCRP) be restricted to 2 in the Ankylosing Spondylitis Disease Activity Score (ASDAS)…
Abstract Number: 2803 • ACR/ARHP Annual Meeting 2017
Predictors of Remission Maintenance up to Week 68 and Successful Therapy Discontinuation in Patients with Non-Radiographic Axial Spondyloarthritis Who Achieved Sustained Remission on 28-Week Open-Label Adalimumab Treatment
Joachim Sieper¹, Robert B.M. Landewé², Marina N. Magrey³, Jaclyn K. Anderson⁴, Sheng Zhong⁴, Xin Wang⁴ and Apinya Lertratanakul⁴, ¹Charité Universitätsmedizin Berlin, Berlin, Germany, ²University of Amsterdam, Amsterdam, Netherlands, ³Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH, ⁴AbbVie Inc., North Chicago, IL
Background/Purpose: Sustained remission is an important treatment goal in patients (pts) with non-radiographic axial SpA (nr-axSpA). Factors predicting successful remission maintenance are unknown. We sought…
Abstract Number: 2938 • ACR/ARHP Annual Meeting 2014
A Randomized, Double-Blind, Placebo-Controlled, 16-Week Study of Subcutaneous Golimumab in Patients with Active Nonradiographic Axial Spondyloarthritis
J Sieper¹, D van der Heijde², M Dougados³, Walter P. Maksymowych⁴, J Boice⁵, G Bergman⁵, S Curtis⁵, A Tzontcheva⁵, S Huyck⁵ and HH Weng⁵, ¹University Clinic Benjamin Franklin, Berlin, Germany, ²Leiden University Medical Center, Leiden, Netherlands, ³Paris-Descartes University, Paris, France, ⁴Department of Medicine, University of Alberta, Alberta, AK, ⁵Merck & Co., Inc., Whitehouse Station, NJ
Background/Purpose Axial spondyloarthritis (axSpA), including ankylosing spondylitis and nonradiographic axial SpA (nr-axSpA), is a chronic inflammatory disease marked by back pain and progressive spinal stiffness.…