Abstracts tagged "non-human primates (NHPs)"

Abstract Number: 2378 • 2013 ACR/ARHP Annual Meeting
Safety Of Mavrilimumab In Cynomolgus Monkeys: Relevance Of Nonclinical Findings In Lung To Human Safety
Patricia C. Ryan¹, Matthew A. Sleeman², Marlon Rebelatto¹, Bing Wang³, Hong Lu⁴, Chi-Yuan Wu³, Dee Wilkins¹, Susan Spitz¹, Gopi Ranganna⁵, Alex Godwood⁶, Alex Michaels⁷, Didier Saurigny⁶, Lorin Roskos⁸, David Close⁶, Heidi Towers⁹, Kathleen McKeever¹ and Rakesh Dixit⁷, ¹Translational Sciences, MedImmune, Gaithersburg, MD, ²Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Cambridge, United Kingdom, ³Clinical Pharmacology and DMPK, Medimmune, Mountain View, CA, ⁴Translational Sciences, MedImmune, Hayward, CA, ⁵Clinical Development, MedImmune, LLC, Cambridge, United Kingdom, ⁶MedImmune, Ltd, Cambridge, United Kingdom, ⁷MedImmune, Gaithersburg, MD, ⁸One MedImmune Way, Medimmune, Gaithersburg, MD, ⁹MedImmune, LLC, Cambridge, United Kingdom
Background/Purpose: GM-CSF plays a central role in the pathogenesis of rheumatoid arthritis (RA) through the activation, differentiation, and survival of macrophages and neutrophils. Mavrilimumab (CAM-3001)…

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