Abstracts tagged "nod-like receptor (NLR) and rheumatoid arthritis (RA)"

Abstract Number: 32 • ACR/ARHP Annual Meeting 2018
T Cell-Intrinsic Nod2 Protects Against Th17-Mediated Autoimmune Arthritis in SKG Mice
Ruth Napier¹, Ellen Lee¹, Emily Vance¹, Paige Snow², Clare Dawson³, Kimberly Samson⁴, Amy Moran⁵, Michael Davey⁶, Shimon Sakaguchi⁷ and Holly Rosenzweig¹, ¹Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, ²Molecular Microbiology and Immunology, VA Portland Health Care System, Portland, OR, ³Portland VA, PORTLAND, OR, ⁴Oregon Health & Science University, Portland, OR, ⁵Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR, ⁶VA Portland Health Care System, Portland, OR, ⁷Osaka University, Osaka, Japan
Background/Purpose: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor known primarily for its role in host protection against bacterial infections. Intriguingly, Nod2…