Abstracts tagged "NFB"

Abstract Number: 21 • 2018 ACR/ARHP Annual Meeting
Elevated EPSTI1 Promote B Cells Hyperactivation through NF-Kb Signaling in Patients with Sjögren ’s Syndrome
Jin-Lei Sun¹, Zhi-Lei Chen², Chao-Feng Lian³, Ti-Hong Shao², Hao-Ze Zhang², Hua Chen³ and Feng-Chun Zhang², ¹Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China, ²Peking Union Medical College Hospital, Beijing, China, ³Rheumatology, Peking Union Medical College Hospital, Beijing, China
Background/Purpose: Sjogren's syndrome (SS) is a common systemic autoimmune disease characterized with aberrant B cells activation. B cells play a key role in the pathogenesis…
Abstract Number: 2083 • 2017 ACR/ARHP Annual Meeting
The Inflammation Induced By Four Types of Calcium Pyrophosphate Crystals Depends on Their Capacity to Stimulate NF-κb and MAPK Pathways
Félix Renaudin¹, Laure Campillo-Gimenez², Pierre Gras³, Christèle Combes⁴, Martine Cohen-Solal¹, Frederic Liote⁵ and Hang-Korng Ea¹, ¹INSERM UMR1132, Paris Diderot University, Paris, France, ²Inserm UMR1132 Bioscar, Paris, France, ³CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁴ENSIACET, CIRIMAT, INPT-UPS-CNRS, Toulouse, France, ⁵University Paris Diderot, Paris, France
Background/Purpose: Calcium pyrophosphate (CPP) crystal-induced inflammation is mainly driven by interleukin (IL)-1β. IL-1β production involves a two-step process including the formation of pro-IL-1β through NF-κB…
Abstract Number: 2436 • 2017 ACR/ARHP Annual Meeting
MiR-146a Upregulates the TLR4/NF-κb Signaling Pathway to Promote Cytokine Expression and Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Yuan-hao Wu^1,2, Wei Liu¹, Lei Zhang³, Bin Xue³, Yi Wang³, Xiao-ya Liu³, Yang Ji⁴, Ran Duan³, Yue Cai³ and Bo Zhang³, ¹Department of Rheumatology and Immunology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, ²Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China, ³First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, ⁴The 272nd Hospital of Chinese People's Liberation Army, Tianjin, China
Background/Purpose: To investigate the role of miR-146a in the activation of toll-like receptor-4 (TLR4)/ nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway, and…
Abstract Number: 2411 • 2016 ACR/ARHP Annual Meeting
Multiple Genetic Susceptibility Loci in Juvenile Idiopathic Arthritis Are Bound By a Set of Transcription Factors
Leah C. Kottyan¹, Halima Moncrieffe², Xiaoting Chen³, Mario Pujato⁴, John B. Harley⁵, Matthew Weirauch⁶ and Susan D. Thompson⁷, ¹3333 Burnet Ave., Cincinnati, Cincinnati, OH, ²Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³Cincinnati Childrens Hospital, Cincinnati, OH, ⁴1Center of Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center; University of Cincinnati, Cincinnati, OH, ⁵Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Childrens Hospital, Cincinnati, OH, ⁶Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁷Center for Autoimmune Disease Genomics and Etiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH
Background/Purpose: Genome wide association studies (GWASs) and dense genotyping of immune-related disease regions have identified 17 loci associated with juvenile idiopathic arthritis (JIA) (p<5×10-8), 11…
Abstract Number: 1207 • 2014 ACR/ARHP Annual Meeting
Novel Role of Liver X Receptor Alpha (LXRα) in the Attenuation of TLR Signalling: Implications in Congenital Heart Block
Susmita Bagchi¹, Mark Halushka², Robert M. Clancy¹ and Jill P. Buyon¹, ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD
Background/Purpose: Anti-SSA/Ro associated congenital heart block provides a unique opportunity to examine the effector arm of immunity and define the molecular mechanisms that link maternal…
Abstract Number: 871 • 2014 ACR/ARHP Annual Meeting
Antimalarials Regulate TLR7/8 Mediated Macrophage Activation Via Epigenetic Modification at the TNFα Promoter
Androo J. Markham^1,2, Mark Halushka³, Cristiana Guiducci⁴, Robert M. Clancy⁵ and Jill P. Buyon⁵, ¹Medicine, New York University School of Medicine, New York, NY, ²Medicine, Equal contributing author, New York, NY, ³Division of Cardiovascular Pathology, John Hopkins Pathology, Baltimore, MD, ⁴Discovery Department, Dynavax Technologies, Berkeley, CA, ⁵Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Maternal anti-SSA autoantibodies contribute to the pathogenesis of congenital heart block by the formation of immune complexes (IC) comprised of Ro and ssRNA (hY3)…
Abstract Number: 1159 • 2013 ACR/ARHP Annual Meeting
Exercise Suppresses Systemic Inflammation Via Inhibition Of NF-κB Activation In Monocytes
Alisa Blazek¹, Derrick Knapik², Lai-Chu Wu³, Nicholas A. Young³, Wael N. Jarjour⁴ and Sudha Agarwal⁵, ¹Molecular, Cellular and Developmental Biology, The Ohio State University, Columbus, OH, ²College of Medicine, The Ohio State University, Columbus, OH, ³Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ⁴Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, ⁵Division of Rheumatology and Immunology, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Inflammation is integral to joint damage and bone erosion in rheumatoid arthritis. We reported previously that physiologic levels of exercise are anti-inflammatory and suppress local…

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