Abstracts tagged "neutrophils and tumor necrosis factor (TNF)"

Abstract Number: 1057 • ACR/ARHP Annual Meeting 2012
A Specific Inhibitor of Spleen Tyrosine Kinase, PRT062607, Is a Potent Modulator of Innate Immune Cell Function
Lynn A. Kamen¹, Gillian Stephens¹, Anjali Pandey² and Uma Sinha¹, ¹Biology, Portola Pharmaceuticals, South San Francisco, CA, ²Chemistry, Portola Pharmaceuticals, South San Francisco, CA
Background/Purpose: Tumor Necrosis Factor-α (TNF-α) is an essential component of the inflammatory stimuli leading to rheumatoid arthritis (RA). Therapeutics targeting TNF-α are the standard of…