Abstracts tagged "Neutrophil Extracellular Traps and adenosine receptors"

Abstract Number: 292 • 2017 ACR/ARHP Annual Meeting
Neutrophil Extracellular Traps Are Induced By Adenosine and Stimulate Release of TNF Alpha from Macrophages in Deficiency of Adenosine Deaminase 2 (DADA2)
Carmelo Carmona-Rivera¹, Kyawt W. Shwin², Jorge A. irizarry-Caro³, Sami S. Khaznadar⁴, Yudong Liu³, Kenneth A. Jacobson⁴, Amanda Ombrello⁵, Deborah L. Stone⁵, Wanxia Li Tsai³, Massimo G. Gadina⁶, Daniel L. Kastner⁵, Ivona Aksentijevich⁵, Mariana J. Kaplan³ and Peter C. Grayson⁷, ¹Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ²Division of Rheumatic Diseases, Dallas VA Medical Center/ UT Southwestern Medical Center, Dallas, TX, ³NIAMS/NIH, Bethesda, MD, ⁴Molecular Recognition Section, NIDDK-NIH, Bethesda, MD, ⁵Inflammatory Disease Section, NHGRI/NIH, Bethesda, MD, ⁶Translational Immunology Section, Office of Science and Technology, NIAMS/NIH, Bethesda, MD, ⁷National Institute of Arthritis, Musculoskeletal and Skin Disease (NIAMS), Bethesda, MD
Background/Purpose: Reduction of adenosine deaminase 2 (ADA2) activity due to autosomal recessive loss of function mutations in the CECR1 gene results in a systemic illness…

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