Abstracts tagged "Neuropsychological Assessment"

Abstract Number: 1506 • ACR Convergence 2024
Cognitive Impairment Prevalence and Most Affected Domains in Patients with SLE by the ACR Comprehensive Neuropsychological Battery
Chrisanna Dobrowolski¹, Juan Pablo Diaz Martinez², Kathleen Bingham², Michelle Barraclough³, Roberta Kretzmann², Maria Carmela Tartaglia⁴, Lesley Ruttan⁵, May Choi⁶, Simone Appenzeller⁷, Sherief Marzouk², Dennisse Bonilla², Patti Katz⁸, Dorcas Beaton⁹, Robin Green², Joan Wither², Laura Patricia Whittall Garcia², Dafna Gladman¹⁰ and Zahi Touma¹¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY, ²University Health Network, Toronto, ON, Canada, ³The University of Manchester, Manchester, United Kingdom, ⁴University Health Network, University of Toronto, Toronto, ON, Canada, ⁵Toronto Rehab/University Health Network - University Centre, Toronto, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷Unicamp, Campinas, SP, Brazil, ⁸UCSF, San Rafael, CA, ⁹Institute for Work & Health, Toronto, ON, Canada, ¹⁰University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹¹University of Toronto, Toronto, ON, Canada
Background/Purpose: Systemic lupus (SLE) has a well-established association with cognitive impairment (CI) and confers worse quality of life. We previously presented descriptive data regarding the…
Abstract Number: 1234 • ACR Convergence 2023
Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort and Its Association with Disease Activity
Jaqueline de amorim¹, Simone Kishimoto¹, Paula Fernandes¹, Roberto Marini², Zahi Touma³, Hermine Brunner⁴ and Simone Appenzeller¹, ¹UNICAMP, Campinas, Brazil, ²Revista Brasileira de Reumatologia, Campinas, Brazil, ³University of Toronto, Toronto, ON, Canada, ⁴Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH
Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
Abstract Number: 1242 • ACR Convergence 2023
Agreement Between Parent- and Self-Report of Executive Function in Adolescents with Childhood-Onset Systemic Lupus Erythematosus
justine ledochowski¹, Sarah Mossad², Tala El Tal³, Victoria Lishak², Ibrahim Mohamed⁴, Joanna Law², Lawrence Ng², Paris Moaf², Asha Jeyanathan², Adrienne Davis², Linda Hiraki², Deborah Levy², Ashley Danguecan² and Andrea Knight², ¹Department of Psychology, The Hospital for Sick Children, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada, ³Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada, ⁴The Hospital for Sick Children, Brampton, ON, Canada
Background/Purpose: Executive functions (EFs) are a set of cognitive skills that enable successful problem solving and goal-directed behavior. EFs are predictive of academic success, mental…
Abstract Number: 0322 • ACR Convergence 2022
Are Virtual Cognitive Assessments Comparable to In-person Assessments in a Systemic Lupus Erythematosus Cohort?
Michelle Barraclough¹, Juan Pablo Diaz-Martinez², Andrea Knight³, Kathleen Bingham⁴, Jiandong Su², Mahta Kakvan², Carolina Munoz², Maria Carmela Tartaglia⁵, Leslet Ruttan⁶, Joan Wither⁷, May Choi⁸, Dennisse Bonilla², Nicole Anderson², Simone Appenzeller⁹, Ben Parker¹⁰, Patricia Katz¹¹, Dorcas Beaton¹², Robin Green⁶, Ian N. Bruce¹³ and Zahi Touma², ¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ³The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁴Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁵University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, ⁶University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁷Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, ⁸Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, ⁹Unicamp, Campinas, São Paulo, Brazil, ¹⁰Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom, ¹¹UCSF, San Rafael, CA, ¹²Institute for Work & Health, Toronto, ON, Canada, ¹³Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom
Background/Purpose: Many in-person research studies, such as ours examining cognitive impairment (CI) in SLE, were paused for safety reasons during the COVID-19 pandemic. To restart…
Abstract Number: 0330 • ACR Convergence 2022
Assessing the Utility of the Montreal Cognitive Assessment as a Screening Tool for Cognitive Impairment in Patients with SLE Using a Bayesian Item-Response Theory Model
Juan Pablo Diaz-Martinez¹, Michelle Barraclough², Kimberley Yuen³, Oshrat Tayer-Shifman⁴, Andrea Knight⁵, Kathleen Bingham⁶, Jiandong Su¹, Mahta Kakvan¹, Carolina Munoz¹, Maria Carmela Tartaglia⁷, Leslet Ruttan⁸, Joan Wither⁹, May Choi¹⁰, Dennisse Bonilla¹, Simone Appenzeller¹¹, Patricia Katz¹², Dorcas Beaton¹³, Robin Green⁸ and Zahi Touma¹, ¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, ³Queen's University School of Medicine, Toronto, ON, Canada, ⁴Meir Medical Center, Kfar Saba, Israel, ⁵The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁶Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁷University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, ⁸University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, ¹⁰Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, ¹¹Unicamp, Campinas, São Paulo, Brazil, ¹²UCSF, San Rafael, CA, ¹³Institute for Work & Health, Toronto, ON, Canada
Background/Purpose: Cognitive impairment (CI) is one of the most common manifestations of neuropsychiatric syndromes in patients with SLE, with a prevalence ranging from 20% to…
Abstract Number: 0363 • ACR Convergence 2022
Centrally-Acting Angiotensin Converting Enzyme Inhibitor (cACEi) and Angiotensin Receptor Blocker (cARB) Use and Cognitive Dysfunction in Patients with Systemic Lupus
Chrisanna Dobrowolski¹, Michelle Barraclough², Jiandong Su³, Milica Tanic⁴, Kathleen Bingham⁵, Leslet Ruttan⁶, Dorcas Beaton⁷, Joan Wither⁸, Maria Carmela Tartaglia⁹, Mahta Kakvan³, Nicole Anderson³, Dennisse Bonilla³, Robin Green⁶ and Zahi Touma³, ¹Icahn School of Medicine at Mount Sinai, New York, NY, ²Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada, ³Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ⁴McMaster University, Toronto, ON, Canada, ⁵Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁶University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁷Institute for Work & Health, Toronto, ON, Canada, ⁸Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, ⁹University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada
Background/Purpose: Cognitive dysfunction (CD) is detectable in 40% of patients with systemic lupus erythematosus (SLE). Despite this high prevalence, there are limited treatment options for…
Abstract Number: 1458 • ACR Convergence 2022
Systemic Lupus Erythematosus (SLE) Patients with Cognitive Impairment Experience More Fatigue Compared to Patients Without Impairment
Delansie Lawrence¹, Jiandong Su¹, Andrea Knight², Kathleen Bingham³, Mahta Kakvan¹, Maria Carmela Tartaglia⁴, Leslet Ruttan⁵, Joan Wither⁶, May Choi⁷, Simone Appenzeller⁸, Nicole Anderson¹, Dennisse Bonilla¹, Patricia Katz⁹, Dorcas Beaton¹⁰, Robin Green⁵, Zahi Touma¹ and Michelle Barraclough¹¹, ¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ²The Hospital for Sick Children, Division of Rheumatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³Centre for Mental Health, University Health Network; Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁴University of Toronto Krembil Neurosciences Centre, Toronto, ON, Canada, ⁵University Health Network-Toronto Rehabilitation Institute, Toronto, ON, Canada, ⁶Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Toronto, ON, Canada, ⁷Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, ⁸Unicamp, Campinas, São Paulo, Brazil, ⁹UCSF, San Rafael, CA, ¹⁰Institute for Work & Health, Toronto, ON, Canada, ¹¹Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, University of Toronto, Centre for Epidemiology Versus Arthritis, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Toronto, ON, Canada
Background/Purpose: Cognitive impairment (CI) is highly prevalent in patients with systemic lupus erythematosus (SLE). Objective prevalence rates are reported as 38% [range: 20% to 80%]…
Abstract Number: 1468 • ACR Convergence 2022
Apathy Measurement in a Cohort of Systemic Lupus Erythematosus
Mike Putman¹, David Gazeley² and Ikechukwu Mbonu³, ¹The Medical College of Wisconsin, Milwaukee, WI, ²Medical College of Wisconsin, Wauwatosa, WI, ³Medical College of Wisconsin, Milwaukee, WI
Background/Purpose: Up to 40% of patients with systemic lupus erythematosus (SLE) have measurable cognitive dysfunction on neuropsychiatric testing. Around 83% of patients are nonadherent with…
Abstract Number: 1474 • ACR Convergence 2022
Quinolinic Acid, a Kynurenine/Tryptophan Pathway Metabolite, Correlates with Abnormalities in Brain Structure and Function in SLE
Erik Anderson, Chris Tang, An Vo, Cynthia Aranow, Bruce Volpe, Betty Diamond and Meggan Mackay, Feinstein Institutes for Medical Research, Manhasset, NY
Background/Purpose: Stimulation of the kynurenine/tryptophan pathway by interferons alpha and gamma, both known contributors to SLE pathogenesis, leads to a potentially neurotoxic imbalance of pathway…
Abstract Number: 0887 • ACR Convergence 2021
Association of Mycophenolate and Azathioprine Use with Cognitive Function in SLE
Chrisanna Dobrowolski¹, Jiandong Su², John McGinley¹, Melissa Fazzari¹, Kathleen Bingham³, Nicole Anderson², Dorcas Beaton⁴, Lesley Ruttan³, Joan Wither², Maria Tartaglia², Mahta Kakvan², Dennisse Bonilla², May Choi⁵, Marvin Fritzler⁶, Patricia Katz⁷, Robin Green², Chaim Putterman¹ and Zahi Touma⁸, ¹Albert Einstein College of Medicine, Bronx, NY, ²University Health Network, Toronto, ON, Canada, ³University of Toronto, University Health Network, Toronto, ON, Canada, ⁴Institute for Work & Health, Toronto, ON, Canada, ⁵Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada, ⁶University of Calgary, Calgary, AB, Canada, ⁷University of California San Francisco, San Francisco, CA, ⁸University of Toronto, Mississauga, ON, Canada
Background/Purpose: Cognitive dysfunction (CD) is a common manifestation of systemic lupus erythematosus (SLE) which can have detrimental consequences for those affected. To date, no treatments…
Abstract Number: 1268 • ACR Convergence 2020
Structural Validity of a Comprehensive Neuropsychological Battery for Assessment of Cognitive Impairment in Systemic Lupus Erythematosus: Exploratory Factor Analysis Confirms Six Cognitive Domains
Bahar Moghaddam¹, Robin Green², Dorcas Beaton³, Kathleen Bingham⁴, Mahta Kakvan⁵, Lesley Ruttan², Carmela Tartaglia⁶, Marvin Fritzler⁷, May Choi⁸, Jiandong Su⁵, Juan Pablo Diaz-Martinez⁵, Dennisse Bonilla⁵, Nicole Anderson⁵, Joan Wither⁵, Patricia Katz⁹ and Zahi Touma¹, ¹University of Toronto, toronto, ON, Canada, ²Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, ³Institute for Work & Health, Toronto, ON, Canada, ⁴Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁵University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁶University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁷Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁸Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁹University of California, San Francisco, Novato, CA
Background/Purpose: Systemic Lupus Erythematosus (SLE) can lead to neuropsychiatric manifestations including cognitive impairment (CI). The gold standard for assessment of SLE cognitive function is the…
Abstract Number: 1276 • ACR Convergence 2020
Using Classification and Regression Tree Analysis to Assess the Construct Validity of the Automated Neuropsychological Assessment Metrics in the Assessment of Cognitive Impairment in SLE Compared to the ACR Neuropsychological Battery
Kimberley Yuen¹, Dorcas Beaton², Kathleen Bingham³, Jiandong Su⁴, Mahta Kakvan⁴, Juan Pablo Diaz-Martinez⁴, Carmela Tartaglia⁵, Lesley Ruttan⁶, Joan Wither⁴, Nicole Anderson⁴, Dennisse Bonilla⁴, May Choi⁷, Marvin Fritzler⁸, Patricia Katz⁹, Robin Green⁶ and Zahi Touma¹⁰, ¹Queen's University School of Medicine; University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, Canada, ²Institute for Work & Health, Toronto, ON, Canada, ³Department of Psychiatry, University of Toronto, Toronto, ON, Canada, ⁴University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ⁵University of Toronto, Krembil Neurosciences Centre, Toronto, ON, Canada, ⁶Toronto Rehabilitation Institute, University Health Network, Toronto, ON, Canada, ⁷Brigham and Women's Hospital | Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁸Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, ⁹University of California, San Francisco, Novato, CA, ¹⁰University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network; Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Cognitive impairment (CI) is common in systemic lupus erythematosus (SLE) patients, however there is no standard screening tool available. The American College of Rheumatology…
Abstract Number: 1508 • ACR Convergence 2020
Blood-Brain Barrier Leakage in Systemic Lupus Erythematosus Is Associated with Gray Matter Loss and Cognitive Impairment
Lyna Kamintsky¹, Steven Beyea², John Fisk², Javeria Hashmi², Antonina Omisade², Cynthia Calkin², Tim Bardouille², Chris Bowen², Maher Quraan², Arnold Mitnitski², Kara Matheson², Alon Friedman² and John Hanly³, ¹Department of Medical Neuroscience, Dalhousie University, Halifax, Canada, ²Dalhousie University, Halifax, Canada, ³Dalhousie University, Halifax, NS, Canada
Background/Purpose: Cognitive impairment is the most frequent manifestation of neuropsychiatric systemic lupus erythematosus (NPSLE), yet the mechanisms underlying it remain poorly understood. The purpose of…
Abstract Number: 1675 • ACR Convergence 2020
Microstructural Damage Is Associated with Age at Disease-onset and Cognitive Impairment in Systemic Lupus Erythematosus
Paulo Julio¹, Renan Frittoli¹, Aline Lapa¹, Thais Caldeira¹, Leticia Rittner¹, Fernando Cendes¹, Roberto Marini¹, Paula Fernandes¹, Lilian Costallat¹ and Simone Appenzeller¹, ¹UNICAMP, Campinas, Brazil
Background/Purpose: To compare corpus callosum (CC) volume and diffusion tensor imaging in systemic lupus erythematosus according to age of disease-onset. Methods: We selected 75 patients with…

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