ACR Meeting Abstracts

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Abstracts tagged "neuropsychiatric disorders"

  • Abstract Number: 0895 • ACR Convergence 2023

    Lipocalin-2 Promotes Cutaneous and Neuropsychiatric Disease in Murine Lupus

    Chaim Putterman1, Elise Mike2 and Sayra Garcia1, 1Albert Einstein College of Medicine, Bronx, NY, 2Johns Hopkins, Bronx, NY

    Background/Purpose: One central mechanism believed to contribute to the pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE) is temporary disruption of the blood brain barrier (BBB).…
  • Abstract Number: 1234 • ACR Convergence 2023

    Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort and Its Association with Disease Activity

    Jaqueline de amorim1, Simone Kishimoto1, Paula Fernandes1, Roberto Marini2, Zahi Touma3, Hermine Brunner4 and Simone Appenzeller1, 1UNICAMP, Campinas, Brazil, 2Revista Brasileira de Reumatologia, Campinas, Brazil, 3University of Toronto, Toronto, ON, Canada, 4Cincinnati Children's Hospital Medical Center, Division of Rheumatology, Cincinnati, OH

    Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
  • Abstract Number: 1460 • ACR Convergence 2023

    Impact of Neuropsychiatric Involvement on Health-related Quality of Life in Patients with Systemic Lupus Erythematosus

    Dionysis Nikolopoulos1, Nursen Cetrez2, Julius Lindblom2 and Ioannis Parodis2, 1Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Substantial proportions of systemic lupus erythematosus (SLE) patients report severe fatigue and adverse Health-related Quality of Life (HRQoL). Particularly neuropsychiatric manifestations have been associated…
  • Abstract Number: 1473 • ACR Convergence 2023

    Mortality from Diseases of the Nervous System in Patients with Lupus in the past Two Decades

    Ansaam Daoud1, Loai Dweik2, Marina Nighat Magrey3 and Omer Pamuk4, 1University Hospitals, Case Western Reserve University, Akron, OH, 2Cleveland Clinic Akron General, Akron, OH, 3Case Western Reserve University, University Hospitals, Cleveland, OH, 4University Hospitals Cleveland Medical Center, Cleveland, OH

    Background/Purpose: SLE is a chronic autoimmune disease and affects many organ systems. Juvenile onset disease, male sex, renal involvement, and central nervous system involvement are…
  • Abstract Number: 1478 • ACR Convergence 2023

    Presentation and Outcomes of Posterior Reversible Encephalopathy Syndrome in Systemic Lupus Erythematosus: A Multicenter Cohort and a Systematic Literature Review

    Alain Sanchez-Rodriguez1, Mariana Gonzalez-Treviño1, Hannah Langenfeld2, Cynthia Crowson3, Maria Valenzuela-Almada4, Alejandro Rabinstein5, Larry J. Prokop6, Isabel Valenzuela-Almada7 and Ali Duarte-Garcia3, 1Division of Rheumatology, Mayo Clinic, Rochester, MN, 2Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, 3Mayo Clinic, Rochester, MN, 4Department of Pediatrics, Children’s National Medical Center, Washington, DC, 5Department of Neurology, Mayo Clinic, Rochester, MN, 6Mayo Clinic Libraries, Mayo Clinic, Rochester, MN, 7Division of Internal Medicine, Hospital Medica Sur, Mexico City, Mexico

    Background/Purpose: To describe the clinical characteristics, therapies, and outcomes of patients with SLE and Posterior reversible encephalopathy syndrome (PRES). Methods: We performed a multicenter cohort…
  • Abstract Number: 1601 • ACR Convergence 2023

    Interleukin-6 Disrupts Blood-cerebrospinal Fluid Barrier Permeability in Murine Neuropsychiatric Lupus

    Joshua Reynolds1, Lola Torz2, Natalia Petersen2, Ayal Ben-Zvi3 and Chaim Putterman1, 1Albert Einstein College of Medicine, Bronx, NY, 2Novo Nordic, Global Obesity Research, Malov, Denmark, 3Hebrew University of Jerusalem, Jerusalem, Israel

    Background/Purpose: In exploring the pathogenic mechanisms underlying neuropsychiatric lupus (NPSLE), it was discovered that cerebrospinal fluid (CSF) from lupus patients often contains neurotoxic antibodies, cytokines,…
  • Abstract Number: 1625 • ACR Convergence 2023

    Identifying Potential Neuroimaging Biomarkers of Neuropsychiatric Lupus in Children Using Deep Learning

    santiago arciniegas1, Matthias W. Wagner2, Logi Vidarsson2, Birgit Ertl-Wagner2, Tala El Tal3, Asha Jeyanathan2, Lawrence Ng2, Linda Hiraki2, Deborah Levy2, George M. Ibrahim2 and Andrea Knight2, 1University of Toronto, Toronto, ON, Canada, 2The Hospital for Sick Children, Toronto, ON, Canada, 3Children's Hospital of Eastern Ontario (CHEO), Ottawa, ON, Canada

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease. Childhood-onset SLE (cSLE) is characterised by a higher frequency of nervous system involvement, known…
  • Abstract Number: 2056 • ACR Convergence 2023

    Pediatric Acute-onset Neuropsychiatric Syndrome: Markers of Inflammation/autoimmunity at Clinical Presentation and Eventual Development of Arthritis and Other Autoimmune Diseases

    Meiqian Ma1, Erin Masteron2 and Jennifer Frankovich1, 1Stanford University School of Medicine, Palo Alto, CA, 2University of Washington School of Public Health, Seattle, WA

    Background/Purpose: Certain psychiatric conditions are associated with systemic inflammatory processes. We aimed to evaluate whether a pediatric condition characterized by a sudden onset of severe…
  • Abstract Number: 2303 • ACR Convergence 2023

    Are Neuropsychiatric Symptoms in Systemic Lupus Erythematosus (NPSLE) Associated with More Frequent Hospitalizations or Exposure to a Greater Number of Immunosuppressive Medications?

    Jaime Vondenberg1, Chao Zhang1 and Emily Littlejohn2, 1Cleveland Clinic Foundation, Cleveland, OH, 2Cleveland Clinic, Cleveland, OH

    Background/Purpose: Neuropsychiatric (NP) symptoms occur in >50% of patients with systemic lupus erythematosus (SLE). A major barrier to research includes the non-specific nature of neuropsychiatric…
  • Abstract Number: 2447 • ACR Convergence 2023

    Interleukin-6 Activates Glial Cells and Induces Cognitive Dysfunction in Murine Neuropsychiatric Lupus

    Joshua Reynolds1, Michelle Huang1, Myriam Meineck2, Tamara Möckel2, Andreas Schwarting2 and Chaim Putterman1, 1Albert Einstein College of Medicine, Bronx, NY, 2University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany

    Background/Purpose: Up to 50% of SLE patients experience neuropsychiatric involvement (neuropsychiatric lupus, or NPLSE) in the form of cognitive deficits, memory loss, depression, and anxiety.…
  • Abstract Number: 0478 • ACR Convergence 2023

    The Long-term Neurodevelopmental Outcome of Children Born to Women with Systemic Sclerosis: Assessment Through a Self-reported Questionnaire by the Mothers and Nneuropsychiatric Evaluations of the Children

    Maria Grazia Lazzaroni1, Eleonora Pedretti1, Liala Moschetti1, Marzia Bendoni2, Lucrezia Visconti2, Anna Molinaro2, Cecilia Nalli3, Franco Franceschini3, Paolo Airò1, Jessica Galli2, Elisa Fazzi2, Angela Tincani4 and Laura Andreoli5, 1Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy, 2Unit of Child and Adolescent Neuropsychiatry, ASST Spedali Civili of Brescia, University of Brescia, Brescia, Italy, 3Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, 4Rheumatology and Clinical Immunology, ASST Spedali Civili of Brescia, University of Brescia, Gussago, Italy, 5University of Brescia, Brescia, Italy

    Background/Purpose: The long-term neuropsychiatric (NP) outcome of children born to mothers affected by autoimmune diseases (AIDs) represents a controversial topic, with few studies1-3 reporting a…
  • Abstract Number: 0550 • ACR Convergence 2023

    Harnessing Machine Learning to Predict Neuropsychiatric Events in Systemic Lupus Erythematosus

    Nursen Cetrez1, Julius Lindblom1, Raffaele Da Mutten2, Dionysis Nikolopoulos2 and Ioannis Parodis1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is linked to increased morbidity, mortality, and adverse health-related quality of life. Early disease, a history of NPSLE, aPL…
  • Abstract Number: 041 • 2023 Pediatric Rheumatology Symposium

    Cognitive Performance Score of the Pediatric Automated Neuropsychological Assessment Metrics Software in a Brazilian Cohort

    Jaqueline De Amorim1, Simone Kishimoto1, Paula Fernandes1, Roberto Marini1, Lilian Costallat1, Zahi Touma2, Hermine Brunner3 and Simone Appenzelle4, 1UNICAMP, São Paulo, Brazil, 2University of Toronto, Toronto, ON, Canada, 3Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 4University of Campinas, Campinas, Sao Paulo, Brazil

    Background/Purpose: The PedAnam (Pediatric Automated Neuropsychological Assessment Metrics) is an automatic software to evaluate cognitive performance that has recently been validated into Portugues (Brazil). The…
  • Abstract Number: 0321 • ACR Convergence 2022

    M-Phase Phosphoprotein 1 (MPP-1) Autoantibodies as a Potential Biomarker for Cranial Neuropathies in an International SLE Inception Cohort

    Eugene Krustev1, John Hanly2, Ricky Chin3, Katherine Buhler1, Francesca S Cardwell4, Murray Urowitz5, Caroline Gordon6, Sang-Cheol Bae7, Juanita Romero-Diaz8, Jorge Sanchez-Guerrero9, Sasha Bernatsky10, Daniel Wallace11, David Isenberg12, Anisur Rahman13, Joan Merrill14, Paul R Fortin15, Dafna Gladman16, Ian N. Bruce17, Michelle Petri18, Ellen M. Ginzler19, Mary Anne Dooley20, Rosalind Ramsey-Goldman21, Susan Manzi22, Andreas Jönsen23, Graciela Alarcón24, Ronald van Vollenhoven25, Cynthia Aranow26, Meggan Mackay26, Guillermo Ruiz-Irastorza27, S. Sam Lim28, Murat İnanç29, Kenneth Kalunian30, Soren Jacobsen31, Christine Peschken32, Diane Kamen33, Anca Askanase34, Jill Buyon35, Marvin Fritzler1, Ann E Clarke36 and May Choi37, 1University of Calgary, Calgary, AB, Canada, 2Division of Rheumatology, Queen Elizabeth II Health Sciences Center (Nova Scotia Rehabilitation Site) and Dalhousie University, Halifax, NS, Canada, 3University of Calgary, Ottawa, ON, Canada, 4University of Waterloo, Department of Geography & Environmental Management, Burlington, ON, Canada, 5University of Toronto, University Health Network, Schroeder Arthritis Institute, Toronto, ON, Canada, 6Rheumatology Research Group, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, 7Hanyang University Medical Center, Seoul, Republic of Korea, 8Instituto Nacional de Ciencias Medicas y Nutricion SZ, Ciudad de México, Mexico, 9Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, ON, Canada, 10Research Institute of the McGill University Health Centre, Montréal, QC, Canada, 11Cedars-Sinai Medical Center, Los Angeles, CA, 12University College London, London, United Kingdom, 13Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, 14Oklahoma Medical Research Foundation, Oklahoma City, OK, 15Centre ARThrite - CHU de Québec - Université Laval, Québec, QC, Canada, 16Toronto Western Hospital, Schroeder Arthritis Institute, Toronto, ON, Canada, 17Centre for Epidemiology Versus Arthritis, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom, 18Johns Hopkins University School of Medicine, Division of Rheumatology, Baltimore, MD, 19SUNY Downstate Health Sciences University, Department of Medicine, Brooklyn, NY, 20Raleigh Neurology Associates, Chapel Hill, NC, 21Northwestern University Feinberg School of Medicine, Chicago, USA, Chicago, IL, 22Allegheny Health Network, Lupus Center of Excellence, Wexford, PA, 23Department of Clinical Sciences, Lund, Section for Rheumatology, Lund University, Lund and Skåne University Hospital, Lund, Sweden, 24The University of Alabama at Birmingham, Oakland, 25Amsterdam University Medical Centers, Amsterdam, Netherlands, 26Feinstein Institutes for Medical Research, Manhasset, NY, 27Autoimmune Diseases Research Unit, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, UPV/EHU, Barakaldo, Spain, 28Emory University, Atlanta, GA, 29Istanbul University Faculty of Medicine, Istanbul, Turkey, 30University of California San Diego, La Jolla, CA, 31Rigshospitalet, Copenhagen, Denmark, 32University of Manitoba, Winnipeg, MB, Canada, 33Medical University of South Carolina, Charleston, SC, 34Columbia University Medical Center, New York, NY, 35NYU Grossman School of Medicine, New York, NY, 36University of Calgary, Division of Rheumatology, Cumming School of Medicine, Calgary, AB, Canada, 37Brigham and Women's Hospital | University of Calgary, Calgary, AB, Canada

    Background/Purpose: We previously reported in a single centre prevalent SLE cohort that antibodies against the cytokinesis-associated protein M-Phase Phosphoprotein 1 (anti-MPP-1) were associated with SLE-related…
  • Abstract Number: 0332 • ACR Convergence 2022

    Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in Cerebrospinal Fluid Relating to Development of Diffuse Psychiatric/Neuropsychological Syndromes in Patients with Systemic Lupus Erythematosus (diffuse NPSLE)

    Yoshiyuki Arinuma1, Yasuhiro Hasegawa2, Yu Matsueda2, Kenji Oku3 and Kunihiro Yamaoka4, 1Kitasato University, Kanagawa, Japan, 2Kitasato University School of Medicine, Sagamihara, Japan, 3Kitasato University, Chigasaki, Japan, 4Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Kanagawa, Japan

    Background/Purpose: Microglial activation is critical for behavioral abnormalities in a mouse model of diffuse NPSLE following anti-glutamate receptor subunit GluN2 antibody (anti-GluN2) exposure to neurons.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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