Abstracts tagged "neuropsychiatric disorders and systemic lupus erythematosus (SLE)"

Abstract Number: 2646 • 2014 ACR/ARHP Annual Meeting
Mood Disorders in Systemic Lupus Erythematousus (SLE): Results from an International, Inception Cohort Study
John G. Hanly for the Systemic Lupus International Collaborating Clinics¹, Li Su², Murray Urowitz³, Juanita Romero-Diaz⁴, Caroline Gordon⁵, Sang-Cheol Bae⁶, Sasha R Bernatsky⁷, Ann E. Clarke⁸, Daniel J. Wallace⁹, Joan T. Merrill¹⁰, David A. Isenberg¹¹, Anisur Rahman¹², Ellen M. Ginzler¹³, Paul Fortin¹⁴, Dafna D. Gladman¹⁵, Jorge Sanchez-Guerrero¹⁶, Michelle Petri¹⁷, Ian Bruce¹⁸, Mary Anne Dooley¹⁹, Rosalind Ramsey-Goldman²⁰, Cynthia Aranow²¹, Graciela S. Alarcon²², Barri J. Fessler²³, Kristján Steinsson²⁴, Ola Nived²⁵, Gunnar K. Sturfelt²⁵, Susan Manzi²⁶, Munther A. Khamashta²⁷, Ronald F. van Vollenhoven²⁸, Asad Zoma²⁹, Manuel Ramos-Casals³⁰, Guillermo Ruiz-Irastorza³¹, S. Sam Lim³², Thomas Stoll³³, Murat Inanc³⁴, Kenneth C. Kalunian³⁵, Diane L. Kamen³⁶, Peter Maddison³⁷, Christine A. Peschken³⁸, Søren Jacobsen³⁹, Anca Askanase⁴⁰, Jill P. Buyon⁴¹, Chris Theriault⁴², Kara Thompson⁴² and Vernon Farewell², ¹Division of Rheumatology, Dalhousie University and Capital Health, Nova Scotia, Canada, Halifax, NS, Canada, ²MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Cambridge, United Kingdom, ³Medicine, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutricion, Mexico city, Mexico, ⁵Rheumatology Research Group, School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, United Kingdom, ⁶Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁷Division of Rheumatology and Clinical Epidemiology, McGill University, Montreal, Quebec, QC, Canada, ⁸Division of Rheumatology, University of Calgary, Alberta, Calgary, AB, Canada, ⁹Rheumatology, Cedars-Sinai/David Geffen School of Medicine at UCLA, Los Angeles, CA, ¹⁰Department of Clinical Pharmacology, Oklahoma Medical Research Foundation, Oklahoma City, OK, ¹¹Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ¹²Centre for Rheumatology Research, University College London, London, United Kingdom, ¹³Rheumatology, SUNY-Downstate Medical Center, Brooklyn, NY, ¹⁴Medicine, Division of Rheumatology, Centre Hospitalier Universitaire de Quebec et Universite Laval, Quebec, QC, Canada, ¹⁵University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, ¹⁶Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada, ¹⁷Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ¹⁸Kellgren Centre for Rheum, Arthritis Research UK Epidemiology Unit, Institution of Inflammation and Repair, University of Manchester, NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals, Manchester Academic Health Sciences Centre, Manchester, United Kingdom, ¹⁹Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, ²⁰Rheumatology, Northwestern University and Feinberg School of Medicine, Chicago, IL, ²¹Feinstein Institute for Medical Research, Mahasset, NY, ²²Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²³Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²⁴Centre for Rheumatology Research, Landspital University Hospital, Reykjavik, Iceland, ²⁵Department of Rheumatology, University Hospital Lund, Lund, Sweden, ²⁶Division of Rheumatology, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²⁷Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ²⁸Unit for clinical therapy research (ClinTrid), Karolinska Institute, Stockholm, Sweden, ²⁹Lanarkshire Centre for Rheumatology, Hairmyres Hospital, East Kilbride, United Kingdom, ³⁰Josep Font Autoimmune Diseases Laboratory, IDIBAPS, Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain, ³¹Autoimmune Diseases Research Unit, Department of Internal Medicine, BioCruces Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, Barakaldo, Spain, ³²Emory University School of Medicine, Division of Rheumatology, Atlanta, GA, ³³Kantonsspital Geissbergstr, Schaffhausen, Switzerland, ³⁴Rheumatology, Division of Rheumatology, Department of Internal Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey, ³⁵UCSD School of Medicine, La Jolla, CA, ³⁶Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ³⁷Ysbyty Gwynedd Bangor, North Wales, United Kingdom, ³⁸University of Manitoba, Canada, Winnipeg, MB, Canada, ³⁹Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ⁴⁰Columbia University Medical Center, New York, NY, ⁴¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁴²Department of Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, NS, Canada
Background/Purpose: Neuropsychiatric (NP) events in patients with SLE include mood disorders. We determined the frequency, characteristics, clinical and autoantibody associations of mood disorders in a…
Abstract Number: 2991 • 2014 ACR/ARHP Annual Meeting
Anti-Ribosomal P Antibody Is a Key Autoantibody Associated with Complications of NP-SLE with High-Levels of CSF IL-8
Hidenaga Kawasumi¹, Takahisa Gono¹, Yasushi Kawaguchi¹, Yasuhiro Katsumata¹, Hisae Ichida¹, Akiko Tochimoto¹, Masanori Hanaoka¹, Yuko Okamoto¹, Sayuri Kataoka¹ and Hisashi Yamanaka², ¹Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, ²Institute of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Complications of neuropsychiatric systemic lupus erythematosus (NP-SLE) are associated with the morbidity and mortality of patients with SLE. Although the detailed pathophysiology of NP-SLE…
Abstract Number: 2992 • 2014 ACR/ARHP Annual Meeting
Usefulness of Diagnostic Biomarker for Neuropsychiatric Systemic Lupus Erythematosus By Anti-Microtubule Associated Protein 2 Antibody in Cerebrospinal Fluid
Yusuke Yamada, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan
Background/Purpose: Microtubule associated protein-2 (MAP-2) is found exclusively in nerve cells. MAP-2 has been shown to stabilize microtubules by binding to the outer surface and…
Abstract Number: 2993 • 2014 ACR/ARHP Annual Meeting
MRI in Neuropsychiatric Lupus: Correlations with the 1999 ACR Case Definitions
Minyoung Her¹, Dongyook Kim², Na young Park², Seong-Kyu Kim³, Lee Sung Won⁴ and Lee sang Yeob⁵, ¹Pusan Paik Hospital, Inje Univ, Inje University, Pusan Paik Hospital, Busan, South Korea, Busan, South Korea, ²Inje University, Pusan Paik Hospital, Busan, South Korea, Busan, South Korea, ³Devision of Rheumatology, Department of Internal Medicine, Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, South Korea, ⁴Dong-A university,Busan, South Korea, Pusan, South Korea, ⁵Dong -A university, Dong-A university,Busan, South Korea, Pusan, South Korea
Background/Purpose: Neurological manifestations in SLE are diverse. Because of its varied manifestations and low prevalence, the ACR has developed nomenclature and case definitions for neuropsychiatric…
Abstract Number: 2654 • 2014 ACR/ARHP Annual Meeting
Cognitive Function in Systemic Lupus Erythematosus Patients with Past History of Neuropsychiatric Manifestations : A Longitudinal Study
Yang Gao¹, Yi Lo¹, Jacky Wan², Esther YY Lau² and Mo Yin Mok¹, ¹Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong, ²Department of Psychology, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Cognitive impairment is commonly reported in patients with systemic lupus erythematosus (SLE) and its associations with neuropsychiatric involvement (NPSLE) and psychiatric factors have been…
Abstract Number: 1597 • 2013 ACR/ARHP Annual Meeting
Autonomic Dysfunction In Systemic Lupus Erythematosus Patients With Previous Neuropsychiatric Involvement
Yang Gao, Sheung Wei Li, Lai Heung Chau, Chak Sing Lau and Mo Yin Mok, Department of Medicine, University of Hong Kong, Hong Kong, Hong Kong
Background/Purpose: Autonomic dysfunction has increasingly been described to be associated with central nervous system (CNS) disorders and has been attributed to damage of the central…
Abstract Number: 1260 • 2013 ACR/ARHP Annual Meeting
Serum S100β Is Associated With Neuropsychiatric Manifestations In Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Bruna Bellini¹, Paula T Fernandes², Roberto Marini³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Faculty of Physical Education, State University of Campinas, Campinas, Brazil, ³State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Involvement of the central nervous system (CNS) in systemic lupus erythematosus (SLE) is an important source of morbidity and mortality. S100β has been considered…
Abstract Number: 221 • 2013 ACR/ARHP Annual Meeting
Detection Of Cerebral Microvascular Lesions In Patients With Acute Phase Neuropsychiatric Systemic Lupus Erythematosus By 7Tesla MRI
Nobuhito Sasaki¹, Okinori Murata¹, Yukari Ninomiya¹, Yuka Oikawa¹, Hitoshi Kobayashi¹, Kohei Yamauchi¹, Makoto Sasaki², Takashi Sawai³ and Yutaka Nakamura¹, ¹Division of Pulmonary medicine, Allergy and Rheumatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan, ²Division of Ultrahigh Field MRI, Iwate Medical University School of Medicine, Morioka, Japan, ³Department of Pathology, Iwate Medical University School of Medicine, Morioka, Japan
Background/Purpose: The cerebral microvascular lesions of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) have not been fully elucidated. The 7Tesla MR scanner has high image…
Abstract Number: 1436 • 2012 ACR/ARHP Annual Meeting
Application of European League Against Rheumatism Recommendations for the Management of Systemic Lupus Erythematosus Patients with Neuropsychiatric Involvement May Limit Unnecessary Diagnostic Testing and Curve Intensification of Immunosuppressive Therapy of Unclear Benefit
Cristina Pamfil¹, Antonios Fanouriakis², Argyro Repa³, Maria Melissourgaki², Prodromos Sidiropoulos³, Ileana Filipescu¹, Mirela Rinzis⁴, Simona Rednic⁴, George Bertsias³ and Dimitrios Boumpas⁵, ¹Rheumatology, University of Medicine and Pharmacy, Cluj-Napoca, Romania, ²Rheumatology, Clinical Immunology, and Allergy, University of Crete, Iraklion, Greece, ³Rheumatology, Clinical Immunology, and Allergy, University of Crete, Heraklion, Greece, ⁴Rheumatology, Emergency County Clinical Hospital Cluj Napoca, Cluj-Napoca, Romania, ⁵Panepistimio Kritis, Rethymnon, Greece
Background/Purpose: Systemic lupus erythematosus (SLE) patients may experience a wide variety of neurological and psychiatric manifestations (neuropsychiatric [NP] SLE [NPSLE]), which pose diagnostic and therapeutic…
Abstract Number: 1431 • 2012 ACR/ARHP Annual Meeting
Single Photon Emission Computed Tomography Contributes to Clinical Assessments in Neuropsychiatric Systemic Lupus Erythematosus Patients
Maasa Hama¹, Mitsuhiro Takeno¹, Atsushi Ihata¹, Daiga Kishimoto¹, Reikou Watanabe¹, Takeaki Uehara², Ryusuke Yoshimi¹, Yukiko Asami¹, Atsuhisa Ueda¹ and Yoshiaki Ishigatsubo¹, ¹Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Rheumatology, Chigasaki Municipal Hospital, Chigasaki, Japan
Background/Purpose: Because the clinical manifestations of NPSLE are diverse, multifaceted approaches are necessary to evaluate the disease activity and therapeutic responses. We investigated contribution of…
Abstract Number: 669 • 2012 ACR/ARHP Annual Meeting
Serum Anti N-Methyl-D-Aspartate Receptor Subunit 1 Antibodies Are Elevated in SLE
Ogawa Eisuke, Nagai Tatsuo, Arinuma Yoshiyuki and Hirohata Shunsei, Rheumatology and infectious diseases, Kitasato University School of Medicine, Kanagawa, Japan
Background/Purpose: Previous studies have demonstrated that the presence of autoantibodies against N-methyl-D-aspartate (NMDA) receptor subunit 2 (NR2) is closely associated with brain damages leading to…
Abstract Number: 299 • 2012 ACR/ARHP Annual Meeting
Reduction of Cerebral and Corpus Callosum Volumes in Childhood-Onset Systemic Lupus Erythematosus. A Volumetric Magnetic Resonance Imaging Analysis
Aline T. Lapa¹, Wesley G. Ferreira¹, Mariana Postal¹, Nailu A. Sinicato¹, Roberto Marini², Fernando Cendes³ and Simone Appenzeller⁴, ¹Medicine, State University of Campinas, Campinas, Brazil, ²State University of Campinas, Campinas, Brazil, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose: Cerebral atrophy has been described to occur in SLE with variable frequency. Aging, systemic diseases, corticosteroid use and central nervous system (CNS) involvement may…
Abstract Number: 2684 • 2012 ACR/ARHP Annual Meeting
Cerebrospinal Fluid IL-6 and Anti-NMDA Receptor NR2 Antibodies As Surrogate Markers for CNS Disease Severity in SLE
Shunsei Hirohata, Yoshiyuki Arinuma and Eisuke Ogawa, Int Med/Rheumatol & Infec Dis, Kitasato University School of Medicine, Sagamihara, Japan
Background/Purpose: Neuropsychiatric manifestations occur in approximately one-half of patients with SLE and may cause substantial impairment of quality of life as well as disability. Among…

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