ACR Meeting Abstracts

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Abstracts tagged "neuropsychiatric disorders"

  • Abstract Number: 1516 • ACR Convergence 2024

    Diagnostic Performance of Anti-ribosomal P Antibodies in Cerebrospinal Fluid of Neuropsychiatric Systemic Lupus Erythematosus with Diffuse Central Nervous System Manifestations. Experience in a Tertiary Center in Mexico

    Marlon Sandino-Bermúdez1, Erik Cimé-Aké2, Jonathan Campos-Guzmán3, Eduardo Briones-García4, Emilio G. Lazarini2, Carlos Núñez-Álvarez5 and Hilda Fragoso-Loyo2, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Distrito Federal, Mexico, 2Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department, Mexico City, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán. Immunology and Rheumatology Department., Ciudad de México, Distrito Federal, Mexico, 5Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX, Mexico, Mexico, Mexico

    Background/Purpose: Diagnosing neuropsychiatric systemic lupus erythematosus (NPSLE) remains a challenge. The aim of this study was to evaluate the diagnostic performance of anti-ribosomal P antibodies…
  • Abstract Number: 2406 • ACR Convergence 2024

    Neuropsychiatric Manifestations in Indian SLE Inception Cohort for Research: Prevalence, Predictors and Outcomes

    Sai Yasaswini Kommaraju1, Liza Rajasekhar2, Ashish J Mathew3, Vineeta Shobha4, Parasar Ghosh5, Chengappa Kavadichanda6, Able Lawrence7, Bidyut Das8, Manish Rathi9, Ranjan Gupta10, Avinash Jain11 and Amita Aggarwal12, 1Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, 2Nizam's Institute of Medical Sciences, Madhapur, Andhra Pradesh, India, 3Christian Medical College, Vellore, Tamil Nadu, India, 4St. John’s Medical College, Bengaluru , India, Bangalore, India, 5Govt of West Bengal, Kolkata, India, Kolkata, West Bengal, India, 6Jawaharlal Institute of Postgraduate Medical Education and Research, pondicherry, Puducherry, India, 7SGPGIMS, Lucknow, Lucknow, Uttar Pradesh, India, 8SCB Medical College, Cuttack, Orissa, India, 9Postgraduate Institute of Medical Education & Research, Chandigarh, Chandigarh, India, 10All India Institute of Medical Sciences, New Delhi, Delhi, India, 11Sawai Man Singh Hospital, Lucknow, Rajasthan, India, 12Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) has a significant impact on morbidity associated with SLE. However, the prevalence of NPSLE has been reported variably based…
  • Abstract Number: 2420 • ACR Convergence 2024

    Blood Transcriptome Analysis Reveals Enhanced B Cell and Complement Cascade Signatures in Patients with Major Neuropsychiatric Systemic Lupus Erythematosus

    Dionysis Nikolopoulos1, George Sentis2, Jason Kitsos2, Panagiotis Garantziotis3, Noemin Kapsala2, antigoni Pieta2, Myrto Nikoloudaki4, Theodora Manolakou5, Sofia Flouda2, Ioannis Parodis6, Anastasia Filia2, George Bertsias7, Antonis Fanouriakis2 and Dimitrios Boumpas8, 1Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 2National and Kapodistrian University of Athens, Athens, Greece, 3Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany, Erlangen, Germany, 4Rheumatology and Clinical Immunology, University of Crete School of Medicine, Heraklion, Greece, Heraklion, Greece, 5Karolinska Institutet, Stockholm, Sweden, 6Karolinska Institutet, Karolinska University Hospital; Örebro University, Solna, Sweden, 7Laboratory of Rheumatology, Autoimmunity and Inflammation. University Hospital, Rheumatology, Clinical Immunology, Heraklion, Greece, 84th Department of Internal Medicine, "Attikon" University Hospital, Athens, Greece, Athens, Greece

    Background/Purpose: The molecular basis of neuropsychiatric systemic lupus erythematosus (NPSLE) remains elusive because of clinical heterogenicity, the complexity of pathophysiologic mechanisms involved and limited access…
  • Abstract Number: 2545 • ACR Convergence 2024

    Phosphodiesterase 1B Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation

    Shuhei Takeyama1, Michihito Kono1, Kohei Karino1, Yuki Kudo1, Masatoshi Kanda2, Hiroyuki Nakamura2, Kenichi Miyamoto1, Kazuro Kamada3, Maria Tada1, Ryo Hisada1, Yuichiro Fujieda1, Masaru Kato1, Olga Amengual4 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 2Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapprp, Japan, 4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe organ manifestations in SLE and is associated with poor quality of life. We…
  • Abstract Number: 2547 • ACR Convergence 2024

    Neurophysiological Phenotypes Are Uncoupled from Toll-like Receptor-Mediated Peripheral Disease in a Mouse Model of Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Cecilia Stumpf1, Vanessa Rodriguez1 and Carla Cuda2, 1Northwestern University, Chicago, 2Northwestern University, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations, including neuropsychiatric symptoms (NPSLE). Despite being a major cause of morbidity…
  • Abstract Number: 0095 • ACR Convergence 2024

    Expansion of Brain T Cell Subsets Outside of the Choroid Plexus in Murine Models of Neuropsychiatric Manifestations of Systemic Lupus Erythematosus

    Minjung Kim1, Cecilia Stumpf2, Hadijat Makinde1, Mohammad Khan1, Vanessa Rodriguez2, Tyler Therron2, Jeremy Tilstra3, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3University of Pittsburgh, Pittsburgh, PA, 4Northwestern University, Skokie, IL

    Background/Purpose: Unclear mechanisms underlying diffuse NPSLE (psychosis, anxiety disorder, cognitive dysfunction) may lead to the devastating impact of this disease on patients’ health-related quality-of-life, representing…
  • Abstract Number: 0096 • ACR Convergence 2024

    Simultaneous Contribution of Brain-Intrinsic and Peripheral Disease Mechanisms to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus (NPSLE)

    Hadijat Makinde1, Mohammad Khan1, Cecilia Stumpf2, Yidan Wang3, Tyler Therron2, Margaret Goldman2, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University, Hanover Park, IL, 4Northwestern University, Skokie, IL

    Background/Purpose: While NPSLE are among the least understood complications, increasing evidence points to microglia, a brain-resident innate immune cell population, as a driver of disease.…
  • Abstract Number: 0653 • ACR Convergence 2024

    Impact of Lupus Nephritis on Neuropsychiatric SLE Outcomes

    Pu-Jun Fang1, Ping Hsuan Kuo2 and Chun Chi Lu1, 1Tri-service general hospital, Taipei, Taiwan (Republic of China), 2Taipei Veterans General Hospital, Taipei City, Taiwan (Republic of China)

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disorder with diverse organ involvement, notably affecting the kidneys and nervous system. Lupus nephritis (LN) and neuropsychiatric…
  • Abstract Number: 1283 • ACR Convergence 2024

    Acute Transverse Myelitis in Pediatric Systemic Lupus Erythematosus

    Meredith Rae1, Emily Beil2, Juan Carlos Torres2, Kristen Fisher2 and Eyal Muscal3, 1Baylor College of Medicine/Texas Children's Hospital, Houston, TX, 2Baylor College of Medicine/Texas Children's Hospital, Houston, 3Baylor College of Medicine, Houston, TX

    Background/Purpose: Transverse myelitis (TM) has an incidence of 1-2% in pediatric SLE and is often a feature of early disease. Most patients ( >60%) have…
  • Abstract Number: 1321 • ACR Convergence 2024

    Neuropsychological Evaluation of Cognitive Impairment in Patients with Rheumatic Diseases

    Gabriela Anais Madrid-Lopez1, Maria Corral-Trujillo2, Ivan Hernandez Galarza3, Jesus Cardenas-de la Garza2 and Dionicio Galarza-Delgado4, 1Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 2Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico, 3University Hospital, UANL, San Pedro Garza Garcia, Nuevo León, Mexico, 4UANL Hospital Universitario, Monterrey, Nuevo León, Mexico

    Background/Purpose: Patients with rheumatic diseases (RD) need their cognitive function intact to perform their daily routine or planning activities. Cognitive function includes orientation, attention/concentration, judgment/problem-solving,…
  • Abstract Number: 1499 • ACR Convergence 2024

    Outcome of Newly Onset SLE with Neuropsychiatric Symptoms and Its Clinical Features in Daily Clinical Practice: A Single Center Study

    Shuzo Sato, Fumitaka Seike, Yuya Sumichika, Kenji Saito, Shuhei Yoshida, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka and Tomoyuki Asano, Fukushima Medical University, Fukushima, Fukushima, Japan

    Background/Purpose: Although neuropsychiatric (NP) symptoms may occur in patients with SLE even in initial onset, studies regarding the distinct clinical features of SLE patients with…
  • Abstract Number: 1506 • ACR Convergence 2024

    Cognitive Impairment Prevalence and Most Affected Domains in Patients with SLE by the ACR Comprehensive Neuropsychological Battery

    Chrisanna Dobrowolski1, Juan Pablo Diaz Martinez2, Kathleen Bingham2, Michelle Barraclough3, Roberta Kretzmann2, Maria Carmela Tartaglia4, Lesley Ruttan5, May Choi6, Simone Appenzeller7, Sherief Marzouk2, Dennisse Bonilla2, Patti Katz8, Dorcas Beaton9, Robin Green2, Joan Wither2, Laura Patricia Whittall Garcia2, Dafna Gladman10 and Zahi Touma11, 1Icahn School of Medicine at Mount Sinai, New York, NY, 2University Health Network, Toronto, ON, Canada, 3The University of Manchester, Manchester, United Kingdom, 4University Health Network, University of Toronto, Toronto, ON, Canada, 5Toronto Rehab/University Health Network - University Centre, Toronto, Canada, 6University of Calgary, Calgary, AB, Canada, 7Unicamp, Campinas, SP, Brazil, 8UCSF, San Rafael, CA, 9Institute for Work & Health, Toronto, ON, Canada, 10University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 11University of Toronto, Toronto, ON, Canada

    Background/Purpose: Systemic lupus (SLE) has a well-established association with cognitive impairment (CI) and confers worse quality of life. We previously presented descriptive data regarding the…
  • Abstract Number: 1515 • ACR Convergence 2024

    Incidence and Predictors of Neuropsychiatric Lupus—a Contemporary Cohort Study Across the United States

    Yomaira Silva1, Baijun Zhou1, Grace Haeun Lee1, Kila Panchot1, Hyon K. Choi2 and April Jorge3, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Lexington, MA, 3Massachusetts General Hospital, Harvard Medical School, Boston, MA

    Background/Purpose: Patients with SLE can experience a variety of neuropsychiatric manifestations across 19 recognized syndromes (1999 ACR Nomenclature). Studies of neuropsychiatric SLE (NPSLE) have been…
  • Abstract Number: 1460 • ACR Convergence 2023

    Impact of Neuropsychiatric Involvement on Health-related Quality of Life in Patients with Systemic Lupus Erythematosus

    Dionysis Nikolopoulos1, Nursen Cetrez2, Julius Lindblom2 and Ioannis Parodis2, 1Karolinska Institutet and Karolinska University Hospital, Division of Rheumatology, Department of Medicine Solna, Stockholm, Sweden, 2Karolinska Institutet, Stockholm, Sweden

    Background/Purpose: Substantial proportions of systemic lupus erythematosus (SLE) patients report severe fatigue and adverse Health-related Quality of Life (HRQoL). Particularly neuropsychiatric manifestations have been associated…
  • Abstract Number: 1473 • ACR Convergence 2023

    Mortality from Diseases of the Nervous System in Patients with Lupus in the past Two Decades

    Ansaam Daoud1, Loai Dweik2, Marina Nighat Magrey3 and Omer Pamuk4, 1University Hospitals, Case Western Reserve University, Akron, OH, 2Cleveland Clinic Akron General, Akron, OH, 3Case Western Reserve University, University Hospitals, Cleveland, OH, 4University Hospitals Cleveland Medical Center, Cleveland, OH

    Background/Purpose: SLE is a chronic autoimmune disease and affects many organ systems. Juvenile onset disease, male sex, renal involvement, and central nervous system involvement are…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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