Abstracts tagged "Neuroendocrine Immune (NEI)"

Abstract Number: 2039 • 2014 ACR/ARHP Annual Meeting
Among Persons Assayed with Lower Serum Interleukin-1 Beta (IL-1β) Levels, Serum Androstenedione (Δ4A) and Testosterone (T) Were Significantly Lower in a Community-Based Cohort of Rheumatoid Arthritis Multi-Years before Clinical Onset (Pre-RA) Than in Non-RA Matched Control (CN) Subjects
Alfonse T. Masi, Azeem A. Rehman and Jean C. Aldag, Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL
Background/Purpose: Dysregulations in androgenic-anabolic (A-A) steroids and cytokines are recognized in RA and pre-RA subjects (Rheum Dis Clin N Am 2005; 31: 131-60). However, deviations…
Abstract Number: 1974 • 2014 ACR/ARHP Annual Meeting
Sex Steroids, Interleukin-1, and Interleukin-10 Inhibit interferon–gamma (IFN-γ) Induced B Cell Activating Factor of the Tumor Necrosis Factor Family (BAFF) in Human Synovial Fibroblasts
Georg Pongratz¹, Marina Bäuml², Tanja Späth², Rainer Straub³ and Torsten Lowin², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose B cell activating factor of the tumor necrosis factor family (BAFF) is a cytokine important for the stimulation and survival of autoreactive B cells…
Abstract Number: 998 • 2014 ACR/ARHP Annual Meeting
β2 Adrenoceptor Signal Is Augmented in B Cells in the Course of Arthritis to Increase IL-10
Georg Pongratz¹, Clemens Wiest², Madlen Melzer² and Rainer Straub³, ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²University Hospital Regensburg, Regensburg, Germany, ³Internal Medicine, University Hospital Regensburg, Regensburg, Germany
Background/Purpose Splenic B cells from collagen-induced arthritis (CIA) mice react to a β2-adrenoceptor (AR) stimulus with increased IL-10 production and adoptive transfer of these cells…
Abstract Number: 1825 • 2013 ACR/ARHP Annual Meeting
Osteoclast Progenitors, Fibroblast-Like Cells and Draining Lymph Node Cells Induce Catecholaminergic-To-Cholinergic Transition Of Sympathetic Nerve Fibers Under Healthy Conditions But Not In Highly Inflamed Arthritic Tissue
Hubert Stangl¹, Dominique Muschter², Susanne Graessel³ and Rainer H. Straub⁴, ¹Department of Internal Medicine 1, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, ²Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital Regensburg, Regensburg, Germany, ³Department of Orthopedic Surgery, Division of Experimental Orthopedic Surgery, University Hospital of Regensburg, Regensburg, Germany, ⁴Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: Sympathetic nerve fibers innervate bone and tissue adjacent to joints. They play an important role in bone and tissue homeostasis. Under certain conditions, sympathetic…
Abstract Number: 1341 • 2013 ACR/ARHP Annual Meeting
Significantly Less Glucocorticoids and Better Patient-Reported Outcomes In Women With Early Inflammatory Arthritis Using Oral Contraceptives Compared To Never Users
Gisela Westhoff¹, Rainer H. Straub², Frank Buttgereit³, Johanna Callhoff⁴ and Angela Zink⁵, ¹Epidemiology Unit, German Rheumatism Research Center Berlin, Berlin, Germany, ²Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany, ³Charité - Universitätsmedizin Berlin, Berlin, Germany, ⁴German Rheumatism Research Center, Berlin, Germany, ⁵German Rheumatism Research Centre and Charité University Medicine, Berlin, Germany
Background/Purpose: Data on the effects of oral contraceptives (OC) on the course of inflammatory arthritis (IA) are controversial. However, a recent analysis of data from…
Abstract Number: 1292 • 2013 ACR/ARHP Annual Meeting
The Spatial Energy Expenditure Configuration and Possible Applications In An Experimental Model Of Arthritis
Susanne Klatt¹ and Rainer H. Straub², ¹Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrine Immunology, University Hospital Regensburg, Regensburg, 93055, Germany, ²Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: An autoimmune response with differentiation and proliferation of immune cells and the subsequent tissue-directed inflammatory process in the symptomatic phase of the disease are…

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