Abstracts tagged "NETosis"

Abstract Number: 798 • 2017 ACR/ARHP Annual Meeting
Altered Phenotype of Platelets and Neutrophils Toward Neutrophil-Platelet Interaction in Circulation of Small and Large Vessel Vasuculitis
Kotaro Matsumoto¹, Hidekata Yasuoka², Komei Sakata¹, Keiko Yoshimoto^1,3, Katsuya Suzuki^1,4, Kunihiro Yamaoka¹ and Tsutomu Takeuchi¹, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ²35 Shinanomachi, Shinjuku, Keio University School of Medicine, Tokyo, Japan, ³Keio University School of Medicine, Clinical and Translational Research Center, Tokyo, Japan, ⁴Division of Rheumatology, Department of Internal Medicine, Keio University School of Medcine, Tokyo, Japan
Background/Purpose: Neutrophils play an important role in the pathogenesis of necrotizing vasculitis, and activation of neutrophil is one of important triggers of the disease process.…
Abstract Number: 1667 • 2017 ACR/ARHP Annual Meeting
Increased Levels of BAFF in SLE Patients Correlates with Neutrophil Activation and Autoantibody Production
Andrew Vasconcellos¹, John Marken¹, Ting Wang^1,2, Christian Lood³ and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China, ³Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: Neutrophil (PMN) activation and neutrophil extracellular trap (NET) formation are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE), particularly in the acceleration of…
Abstract Number: 2899 • 2017 ACR/ARHP Annual Meeting
Trapped Crystals in Synovial Fluid: Neutrophil Extracellular Traps (NETs) from Bench to Bed-Side
Estrella Garcia Gonzalez, Orso Maria Luccherini, Alessandra Gamberucci, Alessandra Ali, Antonella Simpatico, Sauro Lorenzini, Marco Bardelli, Mauro Galeazzi and Enrico Selvi, Rheumatology Unit - Policlinico le Scotte, Siena, Italy
Background/Purpose: Recent data show that neutrophils are able to release chromatin and granular enzymes in web-like structures called neutrophil extracellular traps (NETs). The release of NETs has a physiological…
Abstract Number: 589 • 2016 ACR/ARHP Annual Meeting
Netosis-Derived Products Might Have Diagnostic Potential for Disease Activity, Atherosclerosis and Analysis of Therapeutic Effectiveness in Rheumatoid Arthritis Patients
Chary Lopez-Pedrera¹, Patricia Ruiz-Limon², Carlos Perez-Sanchez¹, Yolanda Jiménez-Gómez¹, Maria Carmen Abalos-Aguilera², Ivan Arias de la Rosa¹, Pedro Segui¹, Pilar Font-Ugalde¹, Maria Ángeles Aguirre Zamorano¹, Jerusalem Calvo-Gutierrez¹, Rafaela Ortega-Castro¹, M. Carmen Castro-Villegas³, Rocio Gonzalez-Conejero⁴, Constantino Martinez⁴, Eduardo Collantes-Estévez¹, Alejandro Escudero-Contreras² and Nuria Barbarroja¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ⁴Regional Centre for Blood Donation, University of Murcia, Murcia, Spain
Background/Purpose: Neutrophil extracellular traps (NETs) have recently been implicated in vascular damage and atherothrombosis. Extruded DNA fibers containing multiple proinflammatory and thrombotic molecules induce the…
Abstract Number: 913 • 2016 ACR/ARHP Annual Meeting
Aggregatibacter Actinomycetemcomitans-Induced Hypercitrullination Links Periodontal Infection to Autoimmunity in Rheumatoid Arthritis
Maximilian F. Konig^1,2, Loreto Abusleme³, Jesper Reinholdt⁴, Robert J. Palmer³, Kevon Sampson¹, Ricardo P. Teles⁵, Peter A. Nigrovic⁶, Antony Rosen¹, Jeremy Sokolove⁷, Jon T. Giles⁸, Niki M. Moutsopoulos³ and Felipe Andrade¹, ¹Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, ⁴Department of Biomedicine, Aarhus University, Aarhus, Denmark, ⁵Department of Periodontology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, ⁶Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁷Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁸Columbia University, College of Physicians and Surgeons, Division of Rheumatology, New York, NY
Background/Purpose: A bacterial etiology of rheumatoid arthritis (RA) has been suspected since the beginnings of modern germ theory. Recent studies implicate mucosal surfaces as sites…
Abstract Number: 2599 • 2016 ACR/ARHP Annual Meeting
TCZ Improves the Pro-Atherothrombotic Profile of Rheumatoid Arthritis Patients Modulating Endothelial Dysfunction, Netosis and Inflammation
Patricia Ruiz-Limon¹, Rafaela Ortega-Castro², IVÁN ARIAS DE LA ROSA², Carlos Perez-Sanchez², Yolanda Jiménez-Gómez², Maria Carmen Abalos-Aguilera¹, Pilar Font-Ugalde², Eduardo Collantes-Estévez², Alejandro Escudero-Contreras², Chary Lopez-Pedrera² and Nuria Barbarroja², ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain
Background/Purpose: Inhibition of the interleukin IL-6 receptor pathway by tocilizumab (TCZ) is an effective treatment for rheumatoid arthritis (RA). TCZ reduces atherosclerosis markers and improves endothelial function.…
Abstract Number: 3148 • 2016 ACR/ARHP Annual Meeting
Peptidylarginine Deiminase 2 Is Required for Tumor Necrosis Factor Alpha Induced Citrullination and Arthritis, but Not Neutrophil Extracellular Trap Formation
Mandar Bawadekar¹, Daeun Shim¹, Ryan Rebernick¹, Chloe Peyton¹, Chad J. Johnson², Thomas F. Warner³, Dres Damgaard⁴, Claus Henrik Nielsen⁵, Anthony P. Nicholas⁶, Ger JM Pruijn⁷, Jeniel E. Nett⁸ and Miriam A. Shelef^1,9, ¹Department of Medicine, Division of Rheumatology, University of Wisconsin-Madison, Madison, WI, ²Department of Medicine, University of Wisconsin-Madison, Madison, WI, ³Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, WI, ⁴Institute for Inflammation Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark, ⁵Danish Rheumatologic Biobank and DANBIO registry, Rigshospitalet, Glostrup, Gentofte and Herlev University Hospital, Copenhagen, Denmark, ⁶Neurology, University of Alabama at Birmingham and Birmingham VA Medical Center, Birmingham, AL, ⁷Biomolecular Chemistry, Institute for Molecules and Materials and Radboud Institute for Molecular Life Sciences, Radboud University, Nijmegen, Netherlands, ⁸Medicine and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI, ⁹William S. Middleton Memorial Veterans Hospital, Madison, WI
Background/Purpose: The presence of anti-citrullinated protein antibodies in rheumatoid arthritis points to a potential role for citrullination in disease pathogenesis. Peptidylarginine deiminases (PADs) catalyze the…
Abstract Number: 1933 • 2015 ACR/ARHP Annual Meeting
Rheumatoid Arthritis Patient T Cells Recognize Neutrophil Extracellular Traps
Dana E. Orange^1,2,3, Nathalie Blachere¹, Salina Parveen¹, John Fak¹, Mayu Frank¹ and Robert Darnell^3,4,5, ¹The Rockefeller University, New York, NY, ²Rheumatology, Hospital for Special Surgery, New York, NY, ³The New York Genome Center, New York, NY, ⁴Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY, ⁵Howard Hughes Medical Institute, New York, NY
Background/Purpose: The majority of patients with rheumatoid arthritis (RA) harbor anti-citrullinated peptide antibodies, which are correlated with more severe disease. Tetramer based assays have demonstrated…
Abstract Number: 3154 • 2015 ACR/ARHP Annual Meeting
The Importance of Somatic Hypermutation for the Immunoreactivity Towards Neutrophil Extracellular Traps (NETs)-Citrullinated Autoantigens of RA Synovial Monoclonal Antibodies
Elisa Corsiero¹, Emanuela Carlotti², Costantino Pitzalis³ and Michele Bombardieri⁴, ¹WHRI - EMR, London, United Kingdom, ²Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, QMUL, London, United Kingdom, ³Centre for Experimental Medicine & Rheumatology, Queen Mary's School of Medicine and Dentistry, London, United Kingdom, ⁴Experimental Medicine and Rheumatology, Queen Mary University of London, London, United Kingdom
Background/Purpose: We previously showed that anti-citrullinated peptide/protein antibodies (ACPA) targeting citrullinated antigens contained in neutrophils extracellular traps (NETs) can be manufactured within ectopic germinal center-like…
Abstract Number: 205 • 2015 ACR/ARHP Annual Meeting
Mode of Action of Therapeutic Anti-Citrullinated Protein Antibodies Revealed: Inflammation Reduction Due to Inhibition of Netosis
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Gonny Schmets¹, Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands
Background/Purpose: Neutrophils together with aberrant Neutrophil Extracellular Trap (NET) formation contribute to the induction and propagation of inflammation. A growing number of studies indicate that…
Abstract Number: 1861 • 2015 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis and the Prothrombotic and Proinflammatory Activities of Monocytes
Carlos Perez-Sanchez¹, M.Ángeles Aguirre Zamorano¹, María Galindo², Patricia Ruiz-Limon¹, Nuria Barbarroja¹, Yolanda Jiménez Gómez¹, Pedro Segui³, Eduardo Collantes-Estevez¹, Mª Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹IMIBIC-Reina Sofia University Hospital, Rheumatology Unit, Cordoba, Spain, ²Department of Rheumatology. Hospital Universitario 12 de Octubre, Madrid, Spain, ³IMIBIC-Reina Sofia University Hospital, Radiology Unit, Cordoba, Spain, ⁴Lupus Research Unit, St Thomas Hospital, London, United Kingdom
Background/Purpose: Atherothrombosis in systemic lupus erythematosus (SLE) has been related to the combined effects of autoimmune elements and cells of the immune system, where monocytes…
Abstract Number: 2917 • 2014 ACR/ARHP Annual Meeting
Inhibition of PAD4 Activity and the Formation of Neutrophil Extracellular Traps Via PTPN22, but Not Its Rheumatoid Arthritis-Prone W620 Variant
I-Cheng Ho¹, Hui-Hsin Chang¹, Nishant Dwivedi¹, Hsiao-Wei Tsao¹ and Anthony Nicholas², ¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Neurology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: One unique feature of rheumatoid arthritis (RA) is the presence of anti-citrullinated protein antibody (ACPA). Protein citrullination, a process mediated by peptidyl arginine deiminases,…
Abstract Number: 815 • 2014 ACR/ARHP Annual Meeting
Netosis Induced Histone Citrullination Facilitates Onset and Propagation of Rheumatoid Arthritis
Dong Hyun Sohn¹, Kazuhiro Onuma¹, Chris Rhodes¹, Xioayan Zhao¹, Tal Gazitt², Rani Shiao¹, Justyna Fert Bober³, Danye Cheng¹, Lauren J. Lahey¹, Heidi Wong⁴, Jennifer van Eyk³, William H. Robinson^1,5 and Jeremy Sokolove¹, ¹VA Palo Alto Healthcare System and Stanford University, Palo Alto, CA, ²Rheumatology, University of Washington, Seattle, WA, ³Johns Hopkins University and Cedars Sinai Medical Center, Los Angeles, CA, ⁴Stanford University School of Medicine, Stanford, CA, ⁵Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA
Background/Purpose: Anti-citrullinated protein antibodies (ACPAs) are characteristic of rheumatoid arthritis however, their presence years before onset of clinical RA is perplexing. Although multiple putative…

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