Abstracts tagged "NETosis"

Abstract Number: 0435 • ACR Convergence 2021
Myeloperoxidase Activity in Individuals with Antineutrophil Cytoplasmic Antibodies (ANCA) Can Be Inhibited by RLS-0071
Parvathi Kumar¹, Pamela Hair¹, Ulrich Thienel¹, Kenji Cunnion¹, Neel Krishna² and Christos Gabriel³, ¹ReAlta Life Sciences Inc, Norfolk, VA, ²ReAlta Life Sciences Inc., Norfolk, VA, ³Children's Hospital of The King's Daughters, Norfolk
Background/Purpose: Anti-neutrophil cytoplasm antibodies (ANCA) are immunoglobulin G (IgG) autoantibodies directed against constituents of primary neutrophil granules (Davies, Moran et al. 1982). There is strong…
Abstract Number: 0538 • ACR Convergence 2021
Strengthening Nuclear Envelope Ameliorates UVB-triggered Skin Inflammation and Kidney Damage in Lupus Mice
Xing Lyu¹, Minghui Li², Ping L Zhang³, Victoria Werth⁴ and Ming-Lin Liu⁴, ¹Tianjin Medical University General Hospital, Philadelphia, PA, ²Tianjin Medical University General Hospital, Tianjin, China (People's Republic), ³Division of Anatomic Pathology,Beaumont Laboratories, Beaumont Health, Royal Oak, MI, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Ultraviolet B (UVB) exposure triggers lupus flare by worsening skin lesions and systemic symptoms such as lupus nephritis. The effects of UVB-induced skin inflammation…
Abstract Number: 22 • 2019 ACR/ARP Annual Meeting
Beta-2 Glycoprotein I as a DNA- and NET-binding Protein
Kelsey Gockman¹, Srilakshmi Yalavarthi ¹, Gautam Sule ¹, Alexandra Morris ¹, Yu Zuo ² and Jason Knight ³, ¹University of Michigan, Ann Arbor, MI, ²University of Texas Southwestern, Dallas, TX, ³Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Beta-2 glycoprotein I (β2GPI) is a prominent autoantigen in antiphospholipid syndrome (APS). As an abundant plasma protein, β2GPI has variably been suggested to have…
Abstract Number: 1789 • 2019 ACR/ARP Annual Meeting
Defibrotide Inhibits Antiphospholipid Antibody-Mediated NET Release and Endothelial Cell Activation
Ramadan Ali¹, Hui Shi ¹, Srilakshmi Yalavarthi ¹ and Jason Knight ², ¹University of Michigan, Ann Arbor, MI, ²Division of Rheumatology, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI
Background/Purpose: Defibrotide is a mixture of phosphodiester oligonucleotides derived from porcine intestinal mucosa, currently approved for treatment of hepatic sinusoidal obstruction syndrome. Defibrotide has been…
Abstract Number: 2789 • 2019 ACR/ARP Annual Meeting
Neutrophil Extracellular Traps Induce Tissue-Invasive Macrophages in Granulomatosis with Polyangiitis Dominated by Ear, Nose and Throat Manifestations
Mitsuhiro Akiyama¹, Nour Ibrahim ², Markus Zeisbrich ¹, Peter Hwang ¹, Jorg Goronzy ¹ and Cornelia Weyand ¹, ¹Stanford University, Stanford, CA, ²Stanford University, Stanford University
Background/Purpose: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis characterized by acute and chronic tissue destruction in the nose, sinuses, lungs and kidneys. In…
Abstract Number: 2792 • 2018 ACR/ARHP Annual Meeting
The Effect of B Cell Targeted Therapies on Autoantibodies and Excessive Neutrophil Extracellular Trap Formation in Systemic Lupus Erythematosus
Laura van Dam¹, Zgjim Osmani¹, Tineke Kraaij¹, Sylvia W.A. Kamerling¹, Jaap A. Bakker², Hans U. Scherer³, Ton Rabelink¹, Reinhard Voll⁴, David A. Isenberg⁵, Cees van Kooten¹ and Y.K. Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands, ³Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Clinic for Rheumatology and Clinical Immunology, University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ⁵University College London, London, United Kingdom
Background/Purpose: Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease characterized by immune-complexes (ICx) which cause inflammation and damage. Effective targeting of autoantibody secreting…
Abstract Number: 2852 • 2018 ACR/ARHP Annual Meeting
Excessive Formation of Neutrophil Extracellular Traps: Different Role in the Pathogenesis of ANCA-Associated Vasculitis and Systemic Lupus Erythematosus
Laura van Dam¹, Tineke Kraaij¹, Sylvia W.A. Kamerling¹, Hans U. Scherer², Ton Rabelink¹, Cees van Kooten¹ and Y.K. Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Department of Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: ANCA-associated vasculitis (AAV) and systemic lupus erythematosus (SLE) both cause glomerulonephritis with pauci-immune and full-house immunofluorescence patterns, respectively. Although AAV and SLE are clinically…
Abstract Number: 2901 • 2018 ACR/ARHP Annual Meeting
Sputum Neutrophils from Individuals at-Risk for RA Demonstrate Increased Citrullinated Histone H3 Containing Neutrophil Extracellular Traps That Correlate with Sputum Anti-Cyclic Citrullinated Peptide Antibody Levels
Yuko Okamoto¹, Nickie L. Seto², Mariana J. Kaplan², Ashley Visser¹, Jill M. Norris³, Kevin D. Deane¹, V. Michael Holers⁴ and M. Kristen Demoruelle¹, ¹Division of Rheumatology, University of Colorado Denver, Aurora, CO, ²Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, MD, ³Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁴Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: Our group previously demonstrated that anti-citrullinated (cit) protein antibodies (ACPA) in the sputum correlate with remnants of neutrophil extracellular traps (NETs) in RA-free subjects…
Abstract Number: 67 • 2018 ACR/ARHP Annual Meeting
Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA
Widian Jubair¹, Elizabeth A. Bemis², Yuko Okamoto³, Marie L. Feser³, Jennifer Seifert³, M. Kristen Demoruelle³, Jill M. Norris⁴, Kevin D. Deane³, V. Michael Holers⁵ and Kristine A Kuhn^1,6, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Rheumatology Division, University of Colorado Denver, Aurora, CO, ⁶Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
Abstract Number: 90 • 2018 ACR/ARHP Annual Meeting
Deoxyribonuclease 1-like-3 Digests Self-DNA from Dead Cells and Prevents Autoimmunity
Shoichiro Inokuchi¹, Hiroki Mitoma², Shotaro Kawano², Masahiro Ayano², Yasutaka Kimoto³, Mitsuteru Akahoshi², Yojiro Arinobu², Koichi Akashi², Takahiko Horiuchi⁴ and Hiroaki Niro⁵, ¹Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan, ²Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan, ³Department of Internal Medicine, Kyushu University Beppu Hospital, Oita, Japan, ⁴Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Background/Purpose: Deoxyribonuclease 1-like-3 (DNase1L3) belongs to Deoxyribonuclease 1(DNase1) family. This nuclease originally identified as one of apoptosis- and necrosis-related endonucleases that fragmentates intranucleosomal DNA. Unlike…
Abstract Number: 766 • 2018 ACR/ARHP Annual Meeting
Neutrophil Extracellular Traps Are a Source of Extracellular High Mobility Group Box-1: Association with Clinical and Histopathological Features in Patients with Lupus Nephritis
Laura Patricia Whittall¹, Diana Gómez-Martín¹, Jiram Torres-Ruíz², Alejandro Zentella Dehesa¹, Miguel Tapia-Rodríguez¹ and Jorge Alcocer-Varela¹, ¹Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ²Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico City, Mexico
Background/Purpose: Current evidence suggests that neutrophils play an important role in the pathophysiology of lupus nephritis (LN) mainly through the secretion of type I IFN…
Abstract Number: 1092 • 2018 ACR/ARHP Annual Meeting
Immune Complex-Driven Neutrophil Activation and BAFF Production Promote B Cell Activation and Autoantibody Production in Human SLE
Andrew Vasconcellos¹, John Marken¹, Sladjana Skopelja-Gardner¹, Christian Lood² and Natalia V. Giltiay¹, ¹Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, ²Division of Rheumatology, Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA
Background/Purpose: The production of anti-nuclear auto-antibodies (Ab) and the formation of immune complexes (IC) are hallmarks of Systemic Lupus Erythematosus (SLE). Enhanced neutrophil (PMN) activation…
Abstract Number: 2078 • 2018 ACR/ARHP Annual Meeting
Induction of Netosis in Ankylosing Spondylitis: Association to Disease Pathogenesis and Modulation By Anti-Tnfα Therapy
Patricia Ruiz-Limon¹, M. Carmen Castro-Villegas², Chary Lopez-Pedrera³, Rafaela Ortega-Castro⁴, Maria Carmen Abalos-Aguilera¹, Nuria Barbarroja⁴, Carlos Perez-Sanchez⁴, Ivan Arias de la Rosa¹, Alejandro Ibáñez-Costa³, Alejandra Maria Patiño-Trives³, Daniel Espejo-Peralbo¹, Pilar Font-Ugalde⁴, Jose Antonio Gonzalez-Reyes⁵, Jose Manuel Villalba⁵, Clementina López-Medina⁴, Alejandro Escudero-Contreras¹, Eduardo Collantes-Estévez⁴ and Yolanda Jiménez-Gómez⁴, ¹Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Córdoba, Spain, ³IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁵Departamento de Biologia Celular, Fisiologia e Inmunología, University of Córdoba, Cordoba, Spain
Background/Purpose: NETosis has been suggested to play a central role in several rheumatology diseases. Nevertheless, this process, and its modulation in therapeutic response has not…
Abstract Number: 293 • 2017 ACR/ARHP Annual Meeting
Expanded Therapeutic ACPA Utility for Different NET-Driven Human (Autoimmune) Diseases
Renato G.S. Chirivi^1,2, Jos W.G. van Rosmalen¹, Kostantinos Kambas³, Gonny Schmets¹, Hans Kalisvaart¹, Galina S. Bogatkevich⁴, Tim Shaw², Helmuth van Es² and Jos M.H. Raats^1,2, ¹ModiQuest BV, Oss, Netherlands, ²Citryll BV, Nijmegen, Netherlands, ³Laboratory of Molecular Hematology, Democritus University of Thrace, Alexandroupolis, Greece, ⁴Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Aberrant Neutrophil Extracellular Trap (NET) formation contributes to the induction and propagation of inflammation and plays a key role in causing tissue damage in…
Abstract Number: 295 • 2017 ACR/ARHP Annual Meeting
Ex Vivo Induced Neutrophil Extracellular Traps Are Intrinsically Different in Anca-Associated Vasculitis and Systemic Lupus Erythematosus
Laura van Dam¹, Tineke Kraaij¹, Sylvia Kamerling¹, Hans U. Scherer², Charles Pusey³, Ton Rabelink¹, Cees van Kooten¹ and Onno Teng¹, ¹Nephrology, Leiden University Medical Center, Leiden, Netherlands, ²Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ³Imperial College, London, United Kingdom
- Background/Purpose: Neutrophil extracellular traps (NETs) are immunogenic, extracellular DNA structures that harness important autoantigens to be recognized by the adaptive immune system. NETs are…

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