Abstracts tagged "Nervous system lupus"

Abstract Number: 1021 • ACR/ARP Annual Meeting 2019
Anti-IFNAR Treatment Does Not Reverse Neuropsychiatric Disease in MRL/lpr Lupus Mice
Michelle Huang¹, Ariel Stock ², Elise Mike ², Roland Kolbeck ³ and Chaim Putterman ⁴, ¹Albert Einstein College of Medicine, Bronx, ²Albert Einstein College of Medicine, Bronx, NY, ³MedImmune, Gaithersburg, MD, ⁴Albert Einstein College of Medicine, New York, NY
Background/Purpose: Many systemic lupus erythematosus patients display a type I interferon (IFN) signature, and IFNα levels and gene signatures have been positively correlated with disease…
Abstract Number: 1028 • ACR/ARP Annual Meeting 2019
Lupus Auto-antibodies Act as Positive Allosteric Modulators at GluN2A-containing NMDA Receptors to Induce Excitotoxicity and Spatial Memory Deficits
Kelvin Chan¹, Jacquelyn Nestor ², Tomas Huerta ², Czeslawa Kowal ², Patricio Huerta ², Bruce Volpe ², Betty Diamond ³ and Lonnie Wollmuth ¹, ¹Stony Brook University School of Medicine, Stony Brook, NY, ²Feinstein Institutes for Medical Research, Manhasset, NY, ³Feinstein Institutes for Medical Research, Manhasset
Background/Purpose: Patients with Systemic lupus erythematosus (SLE) experience various peripheral and central nervous system manifestations including spatial memory impairment. A subset of auto-antibodies (DNRAbs) cross-react…
Abstract Number: 2159 • ACR/ARP Annual Meeting 2019
Pachymeningitis in Rheumatic Disease
Rachel Kneeland¹, John Berry ², Sydney Brandwein ² and Monika Starosta ², ¹Department of Internal Medicine, Advocate Lutheran General Hospital, Park Ridge, IL, ²Advocate Lutheran General Hospital, Park Ridge, IL
Background/Purpose: Pachymeningitis is a rare complication of rheumatic disease. Patients present with hearing loss or other neurologic complications. Diagnosis is made by thickening of dura…
Abstract Number: 2992 • ACR/ARHP Annual Meeting 2014
Usefulness of Diagnostic Biomarker for Neuropsychiatric Systemic Lupus Erythematosus By Anti-Microtubule Associated Protein 2 Antibody in Cerebrospinal Fluid
Yusuke Yamada, Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine, Tokyo, Japan
Background/Purpose: Microtubule associated protein-2 (MAP-2) is found exclusively in nerve cells. MAP-2 has been shown to stabilize microtubules by binding to the outer surface and…
Abstract Number: 2661 • ACR/ARHP Annual Meeting 2014
Serum Neuronal Biomarkers and Brain Atrophy in Childhood-Onset Systemic Lupus Erythematosus
Aline T. Lapa¹, Mariana Postal¹, Nailu A. Sinicato¹, Renata Barbosa², Fernando Cendes³, Roberto Marini⁴ and Simone Appenzeller⁵, ¹Medicine, State University of Campinas, Campinas, Brazil, ²Medicine, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas, Campinas, Germany, ³Neurology, State University of Campinas, Campinas, Brazil, ⁴Departament of Pediatrics, State University of Campinas, Campinas, Brazil, ⁵Medicine, Faculty of Medical Science, State University of Campinas Unicamp, São Paulo, Brazil
Background/Purpose We aimedto investigate the association of serum biomarkers and regional and diffuse brain atrophy in cSLE. Methods We included consecutive cSLE patients (disease-onset before…