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Abstracts tagged "nephritis and vasculitis"

  • Abstract Number: 3045 • ACR/ARHP Annual Meeting 2016

    Immunometabolism in ANCA-Associated Glomerulonephritis

    Peter C. Grayson1, Sean Eddy2, Viji Nair2, Hemang Parikh3, Maja Lindenmeyer4, Laura Mariani2, Huateng Huang2, Wenjun Ju3, Casey Greene5, Clemens Cohen4, Jeffrey Krischer3, Matthias Kretzler2, Peter A. Merkel6 and Felix H. Eichinger2, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Division of Nephrology, University of Michigan, Ann Arbor, MI, 3University of South Florida, Tampa, FL, 4University of Munich, Munich, Germany, 5Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Mounting an inflammatory response requires immune cells to undergo major changes in metabolism. Mediators such as cytokines can specifically alter the metabolism of different…
  • Abstract Number: 3046 • ACR/ARHP Annual Meeting 2016

    Inflammatory Pathways As Shared Molecular Targets Across ANCA-Associated Vasculitis and Nephrotic Syndrome

    Sean Eddy1, Viji Nair1, Hemang Parikh2, Maja Lindenmeyer3, Laura Mariani1, Felix H. Eichinger1, Huateng Huang1, Wenjun Ju2, Casey Greene4, Peter C. Grayson5, Clemens Cohen3, Jeffrey Krischer2, Peter A. Merkel6 and Matthias Kretzler1, 1Division of Nephrology, University of Michigan, Ann Arbor, MI, 2University of South Florida, Tampa, FL, 3University of Munich, Munich, Germany, 4Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, 5National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 6Division of Rheumatology, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: Clinical trials in rare diseases typically test therapeutic efficacy in one disease defined by a particular clinical phenotype. Improved understanding of the molecular mechanisms…
  • Abstract Number: 733 • ACR/ARHP Annual Meeting 2013

    Plasma Levels Of Fibrin/Fibrinogen Degradation Products Might Be a Useful Indicator Of Disease Activity, Classification and Nephritis Complications In Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

    Kuninobu Wakabayashi, Nao Oguro, Yoko Miura, Sho Ishii, Shinya Seki, Masayu Umemura, Takahiro Tokunaga, Hiroyuki Tsukamoto, Sakiko Isojima, Hidekazu Furuya, Ryo Yanai, Kumiko Otsuka, Ryo Takahashi, Takeo Isozaki, Nobuyuki Yajima, Yusuke Miwa and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: It is important to determine the biomarkers for assessing disease activity of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Plasma levels of fibrin/fibrinogen…

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