Abstracts tagged "Neonatal lupus"

Abstract Number: 118 • 2020 Pediatric Rheumatology Symposium
Long-Term Outcomes in Children Born to Anti-Ro and/or anti-La Positive Mothers
Talia Diaz¹, Daniela Dominguez ², Andrea Knight ³, Carl A. Laskin ⁴, Lawrence Ng ², Franklin Silverio ², Earl D. Silverman ⁵ and Linda Hiraki ⁶, ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ³SickKids Research Institute, Toronto, Canada, ⁴Mount Sinai Hospital and University of Toronto, Toronto, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Department of Paediatrics, University of Toronto, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada
Background/Purpose: Neonatal Lupus Erythematosus (NLE) is an acquired autoimmune disorder associated with the transplacental passage of maternal anti-Ro and/or anti-La antibodies. NLE manifestations include cardiac,…
Abstract Number: 1900 • 2019 ACR/ARP Annual Meeting
Assessing Commercial Titers of anti-Ro60 and Ro52 Antibodies to Risk Stratify Surveillance of Anti-Ro/SSA Antibody Positive Pregnancies
Kimberly Robins ¹, Rohit Bhan¹, Catherine Trad ¹, Rebecca Cohen ¹, Miao Chang ¹, Benjamin Wainwright ¹, Mala Masson ¹, Shilpi Mehta-Lee ¹, Peter Izmirly ¹, Robert Clancy ¹, Bettina Cuneo ² and Jill Buyon ¹, ¹NYU School of Medicine, New York, ²Children's Hospital Colorado, Aurora
Background/Purpose: Pregnancy counseling of all anti-Ro positive women includes advice regarding the development of congenital heart block (CHB), albeit the risk is only 2% for…
Abstract Number: 2866 • 2019 ACR/ARP Annual Meeting
Factors Associated with Cardiac Dysfunction in a Longitudinal Follow-Up of Neonatal Lupus
Amit Saxena¹, Peter Izmirly ², Rebecca Bomar ³, Shireen Golpanian ⁴, Deborah Friedman ⁵, Ruth Eisenberg ⁶, Mimi Kim ⁷ and Jill Buyon ², ¹New York University School of Medicine, New York, NY, ²NYU School of Medicine, New York, ³New York University School of Medicine, New York, NY, New York, ⁴Miami Miller School of Medicine, Miami, ⁵New York Medical College, Valhalla, ⁶Albert Einstein College of Medicine, New York, ⁷Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Cardiac manifestations of neonatal lupus (NL) have been associated with significant morbidity and mortality, however there has been minimal information on long-term outcomes of…
Abstract Number: 1301 • 2017 ACR/ARHP Annual Meeting
Congenital Heart Defects in Children Born to Mothers with Rheumatic Disease and Anti-Ro and/or Anti-La Antibodies
Julie Couture¹, Linda T Hiraki², Franklin Silverio¹, Deepika Sharma¹ and Earl Silverman³, ¹Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada, ²Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada, ³Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: Transplacental passage of maternal anti-Ro IgG is thought to be critical in initiating inflammation leading to congenital heart block in neonatal lupus erythematosus (NLE).…
Abstract Number: 2957 • 2017 ACR/ARHP Annual Meeting
Factors Associated with Cardiac Dysfunction in a Longitudinal Follow-up of Neonatal Lupus
Amit Saxena¹, Peter M. Izmirly², Rebecca Bomar², Shireen Golpanian², Deborah Friedman³ and Jill P. Buyon¹, ¹Rheumatology, New York University School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³New York Medical College, Valhalla, NY
Background/Purpose: There are minimal data and no longitudinal studies regarding the long term cardiac health of children with cardiac manifestations of neonatal lupus (NL). This…
Abstract Number: 3117 • 2016 ACR/ARHP Annual Meeting
Development of Autoimmune Diseases and Genetic Predisposition in Children with Neonatal Lupus and Their Unaffected Siblings
Aaron Garza Romero¹, Peter M. Izmirly², Hannah C. Ainsworth³, Miranda Marion³, Carl Langefeld³, Robert Clancy⁴, Jill P. Buyon⁵ and Amit Saxena⁶, ¹Rheumatology, NYU School of Medicine, New York, NY, ²New York University School of Medicine, New York, NY, ³Wake Forest School of Medicine, Winston-Salem, NC, ⁴Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ⁵Medicine, New York University School of Medicine, New York, NY, ⁶Rheumatology, New York University School of Medicine, New York, NY
Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies. This study was initiated to address the…
Abstract Number: 425 • 2015 ACR/ARHP Annual Meeting
Impact of in Utero Hydroxychloroquine Exposure on Age of Onset of Cutaneous Neonatal Lupus
Julie Barsalou¹, Nathalie Costedoat-Chalumeau², Cesar Fors-Nieves³, Ummara Shah⁴, Patrick Brown⁵, Carl Laskin⁶, Nathalie Morel², Kateri Levesque⁷, Jill P. Buyon⁸, Earl Silverman⁹ and Peter M. Izmirly¹⁰, ¹Pediatric Rheumatology, CHU Sainte-Justine, Université de Montréal, Montréal, QC, Canada, ²Internal Medicine Department, Cochin Hospital, “René-Descartes Paris V” University, Paris, France, ³Division of Rheumatology, NYU School of Medicine, New York, NY, ⁴Medicine, Strong Memorial Hospital, University of Rochester, Rochester, NY, ⁵University of Toronto, Toronto, ON, Canada, ⁶Medicine, Rheumatology and Obstetrics and Gynecology, University of Toronto and LifeQuest Centre for Reproductive Medicine, Toronto, ON, Canada, ⁷Internal Medicine, CHU Ste-Justine, Montréal, QC, Canada, ⁸NYU School of Medicine, New York, NY, ⁹Division of Rheumatology, Hospital for Sick Children and University of Toronto, Toronto, ON, Canada, ¹⁰Rheumatology, NYU School of Medicine, New York, NY
Background/Purpose: Biopsy specimens of cutaneous neonatal lupus (cNL) lesions usually show interface dermatitis. Hydroxychloroquine (HCQ) is an effective treatment for interface dermatitis seen in connective…
Abstract Number: 2665 • 2014 ACR/ARHP Annual Meeting
Risk of Hydrocephalus and/or Macrocephaly in Children Born to Mothers with SLE
Catherine Huang¹, Sasha Bernatsky², Christian A. Pineau³, Susan Scott⁴, Ann E. Clarke⁵, Robert W. Platt¹ and Evelyne Vinet⁶, ¹McGill University, Montreal, QC, Canada, ²Divisions of Rheumatology and Clinical Epidemiology, McGill University Health Centre, Montreal, QC, Canada, ³Rheumatology, McGill University Health Centre, Montreal, QC, Canada, ⁴McGill University Health Centre, Montreal, QC, Canada, ⁵Division of Rheumatology, University of Calgary, Calgary, AB, Canada, ⁶McGill University Health Center, Montreal, QC, Canada
Background/Purpose Evidence suggests that both hydrocephalus and macrocephaly could be potential manifestations of neonatal lupus. In a recent study of 87 children born to mothers…
Abstract Number: 1829 • 2014 ACR/ARHP Annual Meeting
Role of Fluorinated Steroids in Preventing the Progression of Anti-SSA/Ro Associated Isolated Congenital Heart Block to Disease Beyond the Conduction System
Ummara Shah¹, Amit Saxena¹, Sara Sahl², Deborah Friedman³, Jill P. Buyon¹ and Peter M. Izmirly², ¹Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ²Medicine, Division of Rheumatology, New York University School of Medicine, New York, NY, ³Division of Pediatric Cardiology, New York Medical College, Valhalla, NY
Background/Purpose: The cardiac manifestations of neonatal lupus (cardiac NL) characteristically present as conduction disease. A major concern is the extension of injury beyond the AV…

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