Abstracts tagged "natural killer (NK) cells and signal transduction"

Abstract Number: 2031 • ACR/ARHP Annual Meeting 2018
Dysregulated NK Cell PLC
Allison A. Throm¹, Joshua B. Alinger¹, Lauren M. Pachman² and Anthony R. French³, ¹Pediatrics, Washington University St Louis, St Louis, MO, ²Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ³Pediatric Rheumatology, Washington University St Louis, Saint Louis, MO
Background/Purpose: Juvenile dermatomyositis (JDM) is a debilitating pediatric autoimmune disease manifesting with characteristic rash and proximal muscle weakness. We investigated signaling abnormalities in immune cell…