Abstracts tagged "myositis and toll-like receptors"

Abstract Number: 1778 • ACR/ARHP Annual Meeting 2013
Physical Interactions Between Histidyl-tRNA Synthetase and Endogenous/Exogenous Alarmins Enhance Immunogenicity In a Model Of Antigen-Induced Myositis
Irina Fernandez¹, Lisa Harlow², William Ridgway³ and Dana P. Ascherman⁴, ¹Rheumatology, University of Miami, Miami, FL, ²Rheumatology and Clinical Immunology, University of Miami Miller School of Medicine, Miami, FL, ³Immunology, Allergy and Rheumatology, University of Cincinnati, Cincinnati, OH, ⁴Medicine/Rheumatology, University of Miami Miller School of Medicine, Miami, FL
Objective: To assess the biological interplay between histidyl-tRNA synthetase (HRS) and different endogenous/exogenous ligands capable of generating signals through MyD88-dependent receptor systems in idiopathic inflammatory…