Abstracts tagged "Myositis and stem cells"

Abstract Number: 1675 • 2012 ACR/ARHP Annual Meeting
Myositis Autoimmunity and Muscle Weakness Are Linked to TNF-Alpha Suppression of Micrornas-1, 133, and 206 in Myoblasts and Myocytes
Robert Georgantas III¹, Katie Streicher¹, Steven A. Greenberg², Lydia Greenlees³, Wei Zhu³, Philip Brohawn⁴, Brandon W. Higgs⁴, Megan Czapiga⁵, Chris Morehouse⁴, Laura Richman⁶, Bahija Jallal⁴, Koustubh Ranade⁵ and Yihong Yao⁶, ¹Translational Science, Medimmune, Inc, Gaithersburg, MD, ²Department of Neurology, Brigham Women's Hospital, Harvard Medical School, Boston, MA, ³Translational Science, MedImmune, LLC, Gaithersburg, MD, ⁴Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ⁵Translational Science, MedImmune, Inc, Gaithersburg, MD, ⁶Translational Sciences, MedImmune, Gaithersburg, MD
Background/Purpose: The molecular basis of myopathies such as dermatomyositis, polymyositis and inclusion-body myositis, which are characterized by chronic muscle inflammation followed by long term skeletal…

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