Abstracts tagged "myopathy"

Abstract Number: 377 • 2018 ACR/ARHP Annual Meeting
Preliminary Validation of Rectus Femoris Muscle Ultrasound in Idiopathic Inflammatory Myopathy Patients
Erica McBride¹, Gulnara Mamyrova¹, Michael Harris-Love², Ahalya Premkumar³, Deloris Koziol⁴, Jianhua Yao³, Lawrence Yao³, Joseph Shrader², Minal Jain², Rodolfo Curiel¹, Frederick W. Miller⁵ and Lisa G. Rider⁵, ¹Department of Medicine, Division of Rheumatology, The George Washington University, Washington, DC, ²Rehabilitation Medicine, National Institutes of Health, Bethesda, MD, ³Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD, ⁴Department Biostatistics, National Institutes of Health, Bethesda, MD, ⁵Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, National Institutes of Health, Bethesda, MD
Background/Purpose: Muscle ultrasound (MUS) offers a cost effective, accessible option for detection of muscle inflammation and atrophy in patients with Idiopathic Inflammatory Myopathies (IIM). The…
Abstract Number: 393 • 2018 ACR/ARHP Annual Meeting
Physical Activity Monitoring Using Wrist-Worn Accelerometer in the Assessment and Follow-up of Patients with Myositis
Océane Landon-Cardinal¹, Damien Bachasson², Perrine Guillaume¹, Mathieu Vautier¹, Nicolas Champtiaux¹, Baptiste Hervier¹, Aude Rigolet¹, Olivier Benveniste¹, Jean-Yves Hogrel² and Yves Allenbach¹, ¹Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, ²Institute of Myology, Pitié-Salpêtrière University Hospital, Paris, France
Background/Purpose: Wrist-worn accelerometers allow the objective estimation of physical activity (PA) in daily life. Recently, the ENMC workshop on outcome measures in myositis suggested to…
Abstract Number: 1349 • 2018 ACR/ARHP Annual Meeting
Rnaseq of Peripheral Blood Mononuclear Cells from Juvenile Dermatomyositis, Necrotizing Myopathy and Controls Are an Aid in Diagnosis
Chiang-Ching Huang¹, Elisha D.O. Roberson², Gabrielle A. Morgan³, Hua Huang⁴, Victoria Hans³ and Lauren M. Pachman^5,6, ¹Zilber School of Public Health, University of Wisconsin at Milwaukee, Milwaukee, WI, ²Depts. of Medicine and Genetics, Division of Rheumatology, Washington University, St. Louis, MO, ³Cure JM Program of Excellence in Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁴Zilber School of Public Health, University of Wisconsin, Milwaukee, Milwaukee, WI, ⁵Cure JM Program of Excellence in Juvenile Myositis Research, Stanley Manne Children’s Research Institute, affiliated with Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁶Pediatric Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: The HMG-Cr form of Necrotizing Myopathy (NM) is a relatively newly recognized entity within the constellation of pediatric inflammatory myopathies. The purpose of this…
Abstract Number: 2289 • 2018 ACR/ARHP Annual Meeting
Granulomatous Myositis: Heterogeneity and Response to Treatment
Yannick Dieudonné¹, Yves Allenbach², Olivier Benveniste³, Sarah Leonard-louis⁴, Baptiste Hervier², Kuberaka Mariampillai³, Beatrice Lannes⁵, Daniel Wendling⁶, Christan Von Frenckell⁷, Nicolas Poursac⁸, Emmanuel Mortier⁹, Christian Lavigne¹⁰, Olivier Hinschberger¹¹, Julie Magnant¹², Bernard Geny¹³, Jean Sibilia¹⁴ and Alain Meyer¹⁵, ¹Département d’Immunologie Clinique et Médecine Interne, Centre de Référence des Maladies Auto-immunes Rares, Hôpitaux Universitaires de Strasbourg, STRASBOURG, France, ²Department of Internal Medicine and Clinical Immunology and Inflammation-Immunopathology-Biotherapy Department (I2B), Pitié-Salpêtrière University Hospital, Assistance Publique-Hôpitaux de Paris, East Paris Neuromuscular Diseases Reference Center, Paris, France, ³Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Neuro-Musculaires Paris Est, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié-Salpêtrière, Paris, France, ⁴Département de Neuropathologie, Centre de Référence des Maladies Neuro-Musculaires Paris Est, Assistance Publique – Hôpitaux de Paris (AP-HP), Hôpital Universitaire Pitié-Salpêtrière, Paris, France, ⁵Département de Pathologie, Hôpitaux Universitaires de Strasbourg, STRASBOURG, France, ⁶Rheumatology, University Hospital - Bourgogne Franche Comté University, Besançon, France, ⁷Département de Rhumatologie, Hôpital Universitaire Sart-Tilman, Liège, Belgium, ⁸9Departement de Rhumatologie, Hôpital Universitaire de Bordeaux, Bordeaux, France, ⁹Departement de Médicine Interne, Hôpital Universitaire Louis Mourier, Colombes, France, ¹⁰Departement de Médicine Interne et Maladies Vasculaires, Hopital Universitaire d'Angers, Angers, France, ¹¹Departement de Médicine Interne, Hôpital Emile Muller, Mulhouse, France, ¹²Departement de Médicine Interne, Hôpital Universitaire de Tours, Tours, France, ¹³Institut de Physiologie EA 3072, Service de Physiologie et d’Explorations Fonctionnelles, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁴Département de Rhumatologie, Centre de Référence des Maladies Auto-immunes Rares, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, ¹⁵15Département de Rhumatologie, Centre de Référence des Maladies Auto-immunes Rares, Hôpitaux Universitaires de Strasbourg, Strasbourg, France
Background/Purpose: Granuloma in the muscle can be found in patients with myopathy. This finding has alternatively been interpreted as either sarcoid myopathy or other myositis…
Abstract Number: 2131 • 2017 ACR/ARHP Annual Meeting
Longitudinal Cohort Study of Anti-PM/Scl Myositis Patients: Mild Muscle and Lung Involvement with Prominent Perivascular Inflammation
Rebecca De Lorenzo¹, Iago Pinal-Fernandez², Maria Casal-Dominguez², Wilson Huang², Jose Cesar Milisenda¹, Cassie Parks², Katherine Pak³, Cheilonda Johnson⁴, Eleni Tiniakou⁵, Jemima Albayda⁶, Julie J. Paik⁶, Sonye K. Danoff⁷, Lisa Christopher-Stine⁷, Andrea Corse⁸ and Andrew Mammen^3,9, ¹Muscle Disease Unit, NIAMS, NIH, Bethesda, MD, ²NIAMS, NIH, Bethesda, MD, ³National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴Medicine/Pulmonology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ⁸Neurology, Johns Hopkins University, Baltimore, MD, ⁹Neurology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: To describe the clinical and serologic features, as well as the disease course and response to therapy of anti-PM/Scl patients. Methods: All Johns Hopkins…
Abstract Number: 2167 • 2017 ACR/ARHP Annual Meeting
Efficacy and Safety of Rituximab in Anti-Synthetase Positive and Negative Patients with Idiopathic Inflammatory Myopathy– a Registry-Based Study
Valérie Leclair, Maryam Dastmalchi, Angeles Shunashy Galindo-Feria and Ingrid E. Lundberg, Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Rituximab (RTX) in idiopathic inflammatory myopathies (IIM) failed to show efficacy in the placebo-controlled Rituximab in Myositis (RIM) trial. However, post hoc analyses indicated…
Abstract Number: 974 • 2016 ACR/ARHP Annual Meeting
Diffuse Scleroderma, Male Sex, and Myopathy Are Associated with Severe Gastrointestinal Dysmotility in Scleroderma
Zsuzsanna McMahan¹, Livia Casciola-Rosen² and Fredrick M. Wigley³, ¹Department of Internal Medicine, Johns Hopkins University, Baltimore, MD, ²Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Despite the fact that up to 90% of scleroderma (SSc) patients are affected by gastrointestinal (GI) dysmotility, features associated with severe GI disease are…
Abstract Number: 1894 • 2016 ACR/ARHP Annual Meeting
Increased Mortality in Systemic Sclerosis Patients with Fibrosing Myopathy
Julie J. Paik¹, Fredrick M. Wigley², Ami A. Shah¹, Andrea Corse³, Laura K. Hummers⁴ and Andrew Mammen⁵, ¹Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ²Rheum Div/Mason F Lord, Johns Hopkins University School of Medicine, Baltimore, MD, ³Neurology, Johns Hopkins University, Baltimore, MD, ⁴Johns Hopkins University School of Medicine, Baltimore, MD, ⁵National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: Skeletal myopathy in systemic sclerosis (SSc) is associated with poor outcomes such as disability. The spectrum of muscle histopathology of weak SSc patients is…
Abstract Number: 2316 • 2016 ACR/ARHP Annual Meeting
Successful Treatment of Statin-Induced Autoimmune Myopathy without Corticosteroids
Geneviève Oligny Longpré¹, Yves Troyanov¹, Marvin J. Fritzler², José Ferreira¹, Ira N. Targoff³, Hélène Couture⁴, Océane Landon-Cardinal¹, Eric Rich¹, Josiane Bourré-Tessier⁵, Anne-Marie Mansour¹, Julie Drouin¹, Sandra Chartrand¹, Edith Villeneuve¹, Jean-Richard Goulet¹, Benjamin Ellezam⁶, Ana Maria Tsanaclis¹, Vincent Morin¹, Marie-Pierre Fournier-Gosselin¹ and Jean-Luc Senécal¹, ¹Université de Montréal, Montréal, QC, Canada, ²Medicine, University of Calgary, Calgary, AB, Canada, ³University of Oklahoma, Oklahoma City, OK, ⁴Université Laval, Québec, QC, Canada, ⁵Université de Montréal, Montreal, QC, Canada, ⁶Centre hospitalier universitaire Ste-Justine, Montréal, QC, Canada
Methods: Our study included all patients from the Université de Montréal AIM cohort (comprising four academic hospitals) with a documented anti-3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) autoantibody. We selected…
Abstract Number: 2330 • 2014 ACR/ARHP Annual Meeting
Construct Validity of the Adult Myopathy Assessment Tool in Individuals with Inclusion Body Myositis
Michael Harris-Love¹, Galen Joe², Todd Davenport³, Joseph Shrader², Beverly McElroy⁴, Goran Rakocevic⁵, Olavo Vasconcelos⁶ and Marinos Dalakas⁵, ¹Geriatrics Service, VA Medical Ctr, Washington, DC, ²Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, ³Department of Physical Therapy, University of the Pacific, Stockton, CA, ⁴National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, ⁵Department of Neurology, Thomas Jefferson University, Philadelphia, PA, ⁶Department of Neurology, Richmond Veterans Affairs Medical Center, Richmond, VA
Background/Purpose The Adult Myopathy Assessment Tool (AMAT) is a 13-item performance-based battery developed to assess function and anaerobic endurance in adults with muscle disease. The…

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