ACR Meeting Abstracts

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Abstracts tagged "Myopathies"

  • Abstract Number: 0932 • ACR Convergence 2020

    Skeletal Muscle Involvement in Systemic Sclerosis Predisposes to Severe Gastrointestinal Tract and Cardiac Muscle Disease

    Reshad Mahmud1, Lei Zhu2, Maureen Laffoon2, Thomas Medsger3 and Robyn Domsic4, 1UPMC, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA, 3University of Pittsburgh School of Medicine, Verona, PA, 4University of Pittsburgh School of Medicine, Pittsburgh, PA

    Background/Purpose: Tissues containing muscle cells are affected in systemic sclerosis (SSc) patients in different organ systems: skeletal muscle, cardiac muscle and gastrointestinal (GI) smooth muscle. …
  • Abstract Number: 1088 • ACR Convergence 2020

    Recruitment Rates of Virtual Remote Research (Tele-Research) in Myositis

    Siamak Moghadam-Kia1, Chester Oddis2, Swamy Venturupalli3, Shalini Mahajan4, Daphne Scaramangas Plumley5, Dana Ascherman6, Nicole Neiman7, Faith Onelangsy7, Diane Koontz1, Kim Goldby-Reffner7, Sedin Dzanco7, Lei Zhu6 and Rohit Aggarwal6, 1University of Pittsburgh Medical Center, Pittsburgh, PA, 2Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA, 3Cedars Sinai Medical Center, Los Angeles, 4Attune Health, Los Angeles, 5Attune Health, Los Angeles, CA, 6University of Pittsburgh, Pittsburgh, PA, 7UPMC, Pittsburgh

    Background/Purpose: There is a paucity of randomized, controlled clinical trials in myositis. Subject enrollment and retention in clinical trials for this rare, heterogeneous disease has…
  • Abstract Number: 0933 • ACR Convergence 2020

    Advanced Multiparametric Magnetic Resonance Imaging of Muscle for Detection and Quantification of Muscle Disease in Systemic Sclerosis

    Julie Paik1, Fredrick Wigley2, Laura Fayad3, Laura Hummers4 and Michael Jacobs1, 1Johns Hopkins University, Baltimore, MD, 2Johns Hopkins University School of Medicine, Baltimore, MD, 3Joh, Baltimore, MD, 4Johns Hopkins Univerisity, Ellicott City, MD

    Background/Purpose: Skeletal myopathy in systemic sclerosis (SSc) is underappreciated yet an important manifestation of SSc. While it has been reported that there are distinct histopathologic…
  • Abstract Number: 1096 • ACR Convergence 2020

    Assessing Interstitial Lung Disease in a Racially Diverse Population with Idiopathic Inflammatory Myositis

    Jammie Law1, Ana Valle2, Katherine Mullins3 and Shereen Mahmood4, 1Montefiore Medical Center, Bronx, NY, 2Albert Einstein College of Medicine, New York, NY, 3Montefiore Medical Center, BROOKLYN, NY, 4Albert Einstein College of Medicine / Montefiore Medical Center, Wantagh, NY

    Background/Purpose: Interstitial lung disease (ILD) is a common extra-muscular manifestation of Idiopathic Inflammatory Myositis (IIM) and increases risk of mortality. Prior studies and registries have focused on either smaller cohorts or predominantly Caucasian/European populations. Our aim was to better characterize the…
  • Abstract Number: 0958 • ACR Convergence 2020

    Tocilizumab in Myositis: Results of a Phase IIb Double-Blind Randomized Controlled Trial

    Rohit Aggarwal1, Howard Rockette2, Swamy Venturupalli3, Galina Marder4, Mazen Dimachkie5, David Gazeley6, Floranne C. Ernste7, Leslie Crofford8, Siamak Moghadam-Kia9, Diane Koontz9, Lei Zhu1 and Chester Oddis10, 1University of Pittsburgh, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, 3Cedars Sinai Medical Center, Los Angeles, 4Northwell, New York, 5Univeristy of Kansas, Medical Center, Kansas City, KS, 6Medical College of Wisconsin, Wauwatosa, WI, 7Mayo Clinic, Rochester, 8Vanderbilt University Medical Center, Nashville, 9University of Pittsburgh Medical Center, Pittsburgh, PA, 10Department of Medicine, Division of Rheumatology, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: To assess the efficacy and tolerability of tocilizumab (anti-IL-6R, TCZ), in a multi-center, randomized, double blind, placebo-controlled trial in refractory adult dermatomyositis (DM) and…
  • Abstract Number: 1097 • ACR Convergence 2020

    Immunophenotypic Characterization of Myeloid Derived Supressor Cells (MDSCs) and Their Relationship to the Clinical Characteristics of Patients with Inflammatory Myopathies

    Hector Culebro1, Jose Torres-Ruiz2, Fabiola Cassiano Quezada1 and Alfredo Perez Fragoso1, 1INCMNSZ, MEXICO, Mexico, 2NIAMS, National Institute of Health, Bethesda

    Background/Purpose: Myeloid derived suppressor cells (MDSCs) including their granulocyte (Gr-MDSCs) and monocyte (Mo-MDSCs) subtypes constitute a cellular subset with potent immune regulatory capacity. An augmented…
  • Abstract Number: 0995 • ACR Convergence 2020

    Jo-1-Binding B Cells Undergo Limited Class-Switching but Are Biased Towards Autoreactive-Prone and Memory B Cell Subsets in Anti-histidyl-tRNA Synthetase Syndrome

    Jennifer Young-Glazer1, Alberto Cisneros2, Erin Wilfong1, Scott Smith1, Leslie J. Crofford1 and Rachel Bonami1, 1Vanderbilt University Medical Center, Nashville, TN, 2Vanderbit University Medical Center, Nashville, TN

    Background/Purpose: Idiopathic inflammatory myopathies (IIM) are systemic autoimmune diseases traditionally classified as dermatomyositis or polymyositis, but these disorders are increasingly defined by the presence of…
  • Abstract Number: 1098 • ACR Convergence 2020

    Anti-cortactin Autoantibodies Are Associated with Key Clinical Features in Adult Myositis but Are Rarely Present in Juvenile Myositis

    Iago Pinal-Fernandez1, Katherine Pak2, Albert Gil-Vila3, Andres Baucells4, Benjamin Plotz5, Maria Casal-Dominguez6, Assia Derfoul7, Maria Angeles Martinez4, Albert Selva-O'Callaghan3, Sara Sabbagh8, Frederick W. Miller1, Lisa G. Rider9, Lisa Christopher-Stine10 and Andrew Mammen6, 1National Institutes of Health, Bethesda, MD, 2NIAMS, NIH, Bethesda, MD, 3Vall d’Hebron Hospital, Barcelona, Spain, 4Sant Pau Hospital, Barcelona, Spain, 5Division of Rheumatology, New York University Langone Health, New York, NY, 6NIH, Bethesda, MD, 7NIAMS, NIH, Bethesda, 8Division of Rheumatology, Department of Pediatrics, Medical College of Wisconsin, Washington, DC, 9Environmental Autoimmunity Group, Clinical Research Branch, NIEHS, NIH, Garrett Park, MD, 10Johns Hopkins University, Baltimore, MD

    Background/Purpose: To define the prevalence and clinical phenotype of anti-cortactin autoantibodies in adult and juvenile myositis.Methods: In this longitudinal cohort study, anti-cortactin autoantibody tiers were…
  • Abstract Number: 1057 • ACR Convergence 2020

    Earlier Cancer Diagnosis After Idiopathic Inflammatory Myopathy Onset Is Associated with Improved Long Term Survival – Results from Four European Cohorts

    Alexander Oldroyd1, Paul New2, Janine Lamb1, William Ollier1, Robert Cooper2, Kuberacka Mariampillai3, Olivier Benveniste3, Jiří Vencovský4, Heřman Mann5, Zoltan Griger6, Melinda Nagy-Vincze6, Katalin Dankó6 and Hector Chinoy7, 1University of Manchester, Manchester, United Kingdom, 2University of Liverpool, Liverpool, United Kingdom, 3Sorbonne Université, Paris, France, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 5Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6University of Debrecen, Debrecen, Hungary, 7The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The idiopathic inflammatory myopathies (IIMs) are strongly associated with the development of clinically detectable cancer. Cancer screening has therefore been advocated in newly diagnosed…
  • Abstract Number: 1060 • ACR Convergence 2020

    B-cell-rich Inflammatory Myopathies in Adults: Striking Association with Connective Tissue Diseases

    Pat Korathanakhun1, Océane Landon-Cardinal2, Valérie Leclair3, Benjamin Ellezam4, Alain Meyer5, Josiane Bourré-Tessier2, Anne-Marie Mansour6, Sandrine Larue7, François Grand'Maison7, Rami Massie8, Matthieu Le Page9, Catherine Isabelle7, Nathalie Routhier6, Flavie Roy10, Minoru Satoh11, Marvin Fritzler12, Jean-Luc Senécal2, Yves Troyanov13, Marie Hudson3, Jason Karamchandani14 and Erin O'Ferrall8, 1Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 2Division of Rheumatology, Centre hospitalier de l'Université de Montréal, Montréal, QC, Canada, 3Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, 4Division of Pathology, Centre hospitalier universitaire Sainte-Justine, Montréal, QC, Canada, 5Service de rhumatologie et Centre de références des maladies autoimmunes rares, Hôpitaux universitaires de Strasbourg, Strasbourg, France, 6Hôpital du Sacré-Coeur de Montréal, Montreal, QC, Canada, 7Hôpital Charles-Lemoyne, Longueuil, QC, Canada, 8Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, Montreal, QC, Canada, 9Centre hospitalier de Lanaudière, Saint-Charles-Borromée, QC, Canada, 10Uiversité de Montréal, Montreal, QC, Canada, 11Department of Clinical Nursing, University of Occupational and Environmental Health, Kitakyushu, Japan, 12Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 13Division of Rheumatology, Hôpital du Sacré-Coeur, Montréal, QC, Canada, 14Department of Pathology, Montreal Neurological Institute and Hospital, Montreal, QC, Canada

    Background/Purpose: Myositis with significant B-cell infiltrates on muscle biopsy has scarcely been described in adults. Radke (2018) found B cells in adult dermatomyositis (DM) and…
  • Abstract Number: 1061 • ACR Convergence 2020

    Daily Myositis Symptom Changes Collected via a Smartphone-Based App Are Associated with Flare Occurrence – Providing Evidence of Potential Digital Biomarkers

    Alexander Oldroyd1, Belay Yimer2, Max Little3, William Dixon2 and Hector Chinoy4, 1University of Manchester, Manchester, United Kingdom, 2Centre for Epidemiology Versus Arthritis, University of Manchester, Manchester, United Kingdom, 3University of Birmingham, Birmingham, United Kingdom, 4The University of Manchester, Manchester, United Kingdom

    Background/Purpose: The concept of idiopathic inflammatory myopathy (IIM) flare is widely used, although no consensus definition exists. Studies have demonstrated the feasibility and utility of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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