Abstracts tagged "muscle biopsy"

Abstract Number: 0714 • ACR Convergence 2021
Diagnostic Accuracy of Electromyogram for Myositis
Lois bolko¹, Sarah Leonard Louis², Jean hugues Salmon¹, Olivier Benveniste³, Yves Allenbach³ and Thierry Maisonobe⁴, ¹Rheumatology, CHU maison blanche, Reims, Reims, France, ²Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neuropathology, Paris, France, ³Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Clinical Immunology and Internal Medicine, Paris, France, ⁴Sorbonne University - AP-HP, Pitié-Salpêtrière Hospital, Department of Neurology, Paris, France
Background/Purpose: The skeletal muscle biopsy is the gold standard for idiopathic inflammatory myopathies (IIM) diagnosis. Myositis specific antibodies are diagnostic biomarkers for IIM but are…
Abstract Number: 418 • 2018 ACR/ARHP Annual Meeting
Dose-Response Relationship between Neuromuscular Electrical Stimulation and Muscle Function in Patients with Rheumatoid Arthritis
Gustavo J. Almeida¹, Samannaaz S. Khoja² and Sara R. Piva¹, ¹Physical Therapy, University of Pittsburgh, Pittsburgh, PA, ²Department of Physical Therapy, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Neuromuscular electrical stimulation (NMES) is a viable intervention to improve impaired muscle function of patients with rheumatoid arthritis (RA). However, there is limited evidence…
Abstract Number: 1353 • 2018 ACR/ARHP Annual Meeting
Autophagy Marker LC3 Accumulates in Immune-Mediated Necrotizing Myopathy Muscle Fibres
Margherita Giannini¹, Francesco Girolamo², Anna Lia², Angela Amati², Luigi Serlenga², Dario D'Abbicco³, Marilina Tampoia⁴, Maria Trojano² and Florenzo Iannone¹, ¹D.E.T.O., Rheumatology Unit - D.E.T.O. - University of Bari (ITALY), Bari, Italy, ²Department of Basic Medical Sciences, Neuroscience and Sense Organs, Unit of Neurophysiopathology, Policlinico Hospital, University of Bari, BARI, Italy, ³Institute of General Surgery ‘G Marinaccio’ (DETO), Policlinico Hospital, University of Bari, BARI, Italy, ⁴Laboratory of Clinical Pathology, University Hospital of Bari, BARI, Italy
Background/Purpose: To investigate the expression of autophagy marker LC3, localization of macrophages and accumulation of misfolded proteins in myofibres of immune-mediated necrotizing myopathy (IMNM) muscle…
Abstract Number: 948 • 2017 ACR/ARHP Annual Meeting
Application of a Diagnostic Algorithm to Identify Inflammatory Myopathy in Systemic Sclerosis
Vandana Bhushan^1,2, Adam Maundrell¹, Charlotte Proudman^1,2, Leah McWilliams¹, Llew Spargo¹, Robert Metcalf¹, Jennifer Walker³, Mandana Nikpour^4,5, Wendy Stevens⁴, Vidya Limaye^1,2 and Susanna Proudman^1,2, ¹Rheumatology Unit, Royal Adelaide Hospital, South Australia, Adelaide, Australia, ²Discipline of Medicine, University of Adelaide, South Australia, Adelaide, Australia, ³Flinders University of South Australia, Adelaide, Australia, ⁴St Vincent's Hospital, Melbourne, Victoria, Melbourne, Australia, ⁵Department of Medicine, University of Melbourne, Victoria, Melbourne, Australia
Background/Purpose: Muscle involvement in systemic sclerosis (SSc) is under-recognised and poorly understood. Reported prevalence varies up to 15%, reflecting lack of consistent definition, the heterogeneous…
Abstract Number: 271 • 2016 ACR/ARHP Annual Meeting
Impaired Satellite Cell Activation and Myofiber Transition during Skeletal Muscle Regeneration in Patients with Polymyositis and Dermatomyositis
Beatriz Hanaoka¹, Prabhakara R. Nagareddy², Marilyn Campbell³, Leslie J. Crofford⁴, Charlotte A. Peterson⁵, Lisa G. Rider⁶ and Frederick W. Miller⁷, ¹Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Nutritional Sciences, University of Alabama at Birmingham, Birmingham, AL, ³University of Kentucky, Lexington, KY, ⁴Medicine, Vanderbilt University Medical Center, Nasville, TN, ⁵College of Health Sciences, University of Kentucky, Lexington, KY, ⁶Rheumatology, George Washington University, Washington, DC, ⁷Environmental Autoimmunity Group, National Institute of Environmental Health Sciences, NIH, Bethesda, MD
Background/Purpose: Satellite cells are myogenic stem cells that are essential for myofiber repair, growth and homeostasis in postnatal life. A decline in satellite cell performance…
Abstract Number: 946 • 2015 ACR/ARHP Annual Meeting
Novel Tripartite Motif Proteins Linked to Membrane Integrity As Biomarkers of Dermatomyositis and Polymyositis
Kevin McElhanon¹, Jenna Alloush¹, Nicholas A. Young², Zarife Sahenk³, Rohit Aggarwal⁴, Chester V. Oddis⁵, Wael N. Jarjour² and Noah Weisleder¹, ¹Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, ²Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ³Neurology, Research Institute at Nationwide Children's Hospital, Columbus, OH, ⁴Department of Medicine / Rheumtology, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁵Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: The mechanisms that contribute to the pathogenesis of the idiopathic inflammatory myopathies remains largely unknown. This heterogeneous group of diseases involve autoimmunity toward muscles…
Abstract Number: 2220 • 2014 ACR/ARHP Annual Meeting
Overexpression of Ankyrin Repeat Domain Containing Protein 1 Gene (ANKRD1) in Polymyositis Muscle Biopsies Is Correlated to Hypoxia
Samuel Katsuyuki Shinjo¹, Sueli Mieko Oba-Shinjo², Miyuki Uno² and Suely Kazue Nagahashi Marie², ¹Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ²Neurology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: ANKRD1 codes for ankyrin repeat domain containing protein 1, which belongs to the muscle ankyrin repeat protein family involved in a mechano-signaling pathway that…

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