Abstracts tagged "Multicenter study"

Abstract Number: 2290 • 2019 ACR/ARP Annual Meeting
A Multicentre Study of 244 Pregnancies in Women with Undifferentiated Connective Tissue Disease: Foetal/Perinatal and Maternal Outcomes and Disease Evolution Towards a Definite Connective Tissue Disease
Massimo Radin¹, Karen Schreiber ², Irene Cecchi ¹, Alessandra Bortoluzzi ³, Francesca Crisafulli ⁴, Cristiano M. De Freitas ⁵, Beatrice Bacco ¹, Elena Rubini ¹, Silvia Grazietta Foddai ¹, Melissa Padovan ³, Silvia Gallo Cassarino ¹, Franco Franceschini ⁶, Danieli Andrade ⁷, Chiara Benedetto ⁸, Marcello Govoni ⁹, Tiziana Bertero ¹, Luca Marozio ¹, Dario Roccatello ¹, Laura Andreoli ⁴ and Savino Sciascia ¹⁰, ¹University of Turin, Turin, Italy, ²Department of Rheumatology, Copenhagen University Hospital, Copenhagen, Denmark, ³University of Ferrara, Ferrara, Italy, ⁴University of Brescia, Brescia, Italy, ⁵Universidade de Sao Paolo, San Paolo, Brazil, ⁶Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy, Brescia, Italy, ⁷Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, Sao Paulo, Brazil, ⁸University of Turin, Turin, Piemonte, Italy, ⁹University of Ferrara, Rheumatology Unit, Ferrara, Italy, ¹⁰Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
Background/Purpose: Undifferentiated connective tissue disease(UCTD) represents a common autoimmune condition in clinical practice, however, therapeutic strategies and follow-up are mostly based on clinician expertise. Little…
Abstract Number: 1616 • 2018 ACR/ARHP Annual Meeting
Region-Specific Differences in Clinical Presentation of Patients with Axial Spondyloarthritis – Results from a Large Multinational Cohort Study
Denis Poddubnyy¹, Robert D Inman², Joachim Sieper¹, Fabiana Ganz³ and Maja Hojnik⁴, ¹Charité Universitätsmeidzin Berlin, Berlin, Germany, ²Department of Medicine, University of Toronto, Toronto, ON, Canada, ³AbbVie, Baar, Switzerland, ⁴AbbVie, Ljubljana, Slovenia
Background/Purpose: There is limited evidence on the phenotypic characteristics of axial spondyloarthritis (axSpA) patients (pts) in various geographic regions around the world. This analysis aimed…
Abstract Number: 2413 • 2018 ACR/ARHP Annual Meeting
Pregnancy Outcomes in Mixed Connective Tissue Disease: Results from a Multicentre Cohort Study
Massimo Radin¹, Karen Schreiber², Maria Jose Cuadrado³, Irene Cecchi⁴, Laura Andreoli⁵, Franco Franceschini⁶, Maria Teresa Caleiro⁷, Danieli Andrade⁸, Elena Gibbone⁹, Munther A Khamashta¹⁰, Jill P. Buyon¹¹, Peter M. Izmirly¹², Maria Aguirre¹³, Chiara Benedetto⁹, Dario Roccatello¹⁴, Luca Marozio¹⁵ and Savino Sciascia¹⁶, ¹Department of Clinical and Biological Sciences, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ²Department of Thrombosis and Haemophilia, Guy's and St Thomas' Hospital, London, United Kingdom., London, United Kingdom, ³Clinica Universidad de Navarra, Madrid, Spain, ⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Turin, Italy, ⁵Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy, ⁶Department of Clinical and Experimental Sciences, Spedali Civili and University of Brescia, Brescia, Italy, Rheumatology and Clinical Immunology, Brescia, Italy, ⁷Rheumatology, University of São Paulo, Tucson, AZ, ⁸Rheumatology, Hospital das Clinicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁹University of Turin, Turin, Italy, ¹⁰Graham Hughes Lupus Research Laboratory, The Rayne Institute, London, United Kingdom, ¹¹Medicine, New York University School of Medicine, New York, NY, ¹²NYU Langone Health, New York, NY, ¹³IMIBIC, Cordoba, Cordoba, Spain, ¹⁴Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin and S. Giovanni Bo, Turin, Italy, ¹⁵University of Turin, Torino, Italy, ¹⁶Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Center of Research of Immunopathology and Rare Diseases- Coordinating Center of Piemonte and Valle d’Aosta Network for Rare Diseases, Department of Clinical and Biological Sciences, University of Turin, Italy, Torino, Italy
Background/Purpose: Mixed connective tissue disease (MCTD) is characterized by signs and symptoms of a combination of disorders, primarily systemic lupus erythematosus (SLE), scleroderma and polymyositis…
Abstract Number: 1441 • 2017 ACR/ARHP Annual Meeting
Evaluation of Ultrasound-Detecting Efficacy of Abatacept By Profiling Multiple Serum Cytokines, Chemokines and Bone-Related Biomarkers in Rheumatoid Arthritis Patients: Kyushu Multicenter Rheumatoid Arthritis Ultrasound Prospective Observational Cohort Study
Shinya Kawashiri^1,2,3, Ayako Nishino^3,4, Nobutaka Eiraku³, Tamami Yoshitama³, Naoki Matsuoka³, Toshiyuki Aramaki³, Yukitaka Ueki³, Akitomo Okada³, Hiroaki Hamada³, Shuji Nagano³, Keita Fujikawa³ and Atsushi Kawakami^1,3, ¹Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ²Departments of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Kyushu multicenter rheumatoid arthritis ultrasound prospective observational cohort study group, Nagasaki, Japan, ⁴Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Background/Purpose: We have been prospectively investigating therapeutic efficacy of biologic or targeted synthetic DMARDs in patients with rheumatoid arthritis (RA) by ultrasound (US) in Kyushu…
Abstract Number: 836 • 2016 ACR/ARHP Annual Meeting
Comprehensive Characterization of Calcinosis in a Multicenter International Cohort of Patients with Systemic Sclerosis
Antonia Valenzuela^1,2, Jessica K. Gordon³, Tatiana Sofia Rodriguez-Reyna⁴, Susanna Proudman^5,6, Murray Baron⁷, Monique Hinchcliff⁸, Dinesh Khanna⁹, Amber Young¹⁰, Flavia V. Castelino¹¹, Sara R. Schoenfeld¹², Virginia D. Steen¹³, David Fiorentino¹⁴ and Lorinda Chung¹⁵, ¹Division of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, ²Stanford University School of Medicine, Stanford, CA, ³Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, ⁵Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia, ⁶Discipline of Medicine, University of Adelaide, Adelaide, Australia, ⁷Rheumatology, McGill University, Jewish General Hospital, Montreal, QC, Canada, ⁸Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁹University of Michigan, Ann Arbor, MI, ¹⁰Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI, ¹¹Rheumatology, Allergy, Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹²Rheumatology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ¹³Rheumatology, Georgetown University Medical Center, Washington, DC, ¹⁴Department of Dermatology, Stanford University School of Medicine, Palo Alto, CA, ¹⁵Rheumatology, Stanford University Medical Center, Palo Alto, CA
Background/Purpose: Calcinosis cutis is a debilitating complication of systemic sclerosis (SSc) affecting one quarter of patients. Repetitive trauma may be involved in the pathogenesis of…
Abstract Number: 1210 • 2016 ACR/ARHP Annual Meeting
A Genome-Wide Association Study of Psoriatic Arthritis in Italian Population
Mariagrazia Catanoso¹, Pierluigi Macchioni¹, Salvatore D'Angelo², Antonio Marchesoni³, Roberta Ramonda⁴, Alberto Cauli⁵, Fabio Massimo Perrotta⁶, Roberto Bortolotti⁷, Guseppe Provenzano⁸, Giovanni Pistone⁹, Katya Boito¹⁰, Cristina Giuliani¹¹, Paolo Garagnani¹¹, Davide Gentilini¹², Mariana Lofrano¹³, Laura Rotunno¹⁴, Mariagrazia Lorenzin¹⁵, Ignazio Olivieri¹³, Alessandro Mathieu¹⁶, Guido Valesini¹⁷, Giuseppe Paolazzi⁷, Roberto Baricchi¹⁸, Anna Maria Di Blasio¹², Luigi Boiardi¹⁹, Claudio Franceschi²⁰ and Carlo Salvarani¹, ¹Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, ²Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, matera, Italy, ³Rheumatology Unit, Orthopedic Institute G. Pini, Milano, Italy, ⁴Rheumatology Unit, Department of Medicine DIMED, University of Padova, Padova, Italy, ⁵University of Cagliari, Cagliari, Italy, ⁶Rheumatology Unit, Sapienza University, Department of Internal Medicine and Medical Specialties, Roma, Italy, ⁷Rheumatology Unit, Santa Chiara Hospital, Trento, Italy, ⁸Reumatology Unit, Villa Sofia-CTO Hospital, Palermo, Italy, ⁹Rheumatology Unit, ARNAS Civico, Di Cristina e Benfratelli Hospital, Palermo, Italy, ¹⁰Transfusion Medicine Unit,, Arcispedale S. Maria Nuova, IRCCS, Reggio Emilia, Italy, ¹¹Laboratory of Molecular Anthropology, Centre for Genome Biology University, Bologna, Italy, ¹²Laboratory of Molecular Biology, Istituto Auxologico Italiano, IRCCS, Milano, Italy, ¹³Rheumatology Department of Lucania, San Carlo Hospital of Potenza and Madonna delle Grazie Hospital of Matera, Matera, Italy, ¹⁴Orthopedic Institute G.Pini, Rheumatology Unit, Milano, Italy, ¹⁵Department of Medicine, University of Padova - Rheumatology Unit, Padova, Italy, ¹⁶Department of Medical Sciences, Rheumatology Unit - University of Cagliari, Cagliari, Italy, ¹⁷Internal Medicine and Medical Specialties Department, Policlinico Umberto I, La Sapienza University of Rome, Roma, Italy, ¹⁸Transfusion Medicine Unit, IRCCS S. Maria Nuova Hospital, Reggio Emilia, Italy, ¹⁹Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, ²⁰Laboratory of Molecular Anthropology & Centre for Genome Biology University of Bologna, Bologna, Italy
rexm-rs12191877 (p=4.87 x10-10, OR 1.731, 95%CI =1.46-2.06), exm-rs4947248 (p=1.98 x10-9 , OR 1.56, 95%CI = 1.35-1.80). Moreover, in PsA patients we identified signals of association…
Abstract Number: 1818 • 2016 ACR/ARHP Annual Meeting
Predictors for Mortality in Hospitalized Patients with Systemic Lupus Erythematosus from 1999 to 2009: A Follow-up Multicenter Study in China
Xuebing Feng¹, Wenyou Pan², Lin Liu³, Min Wu⁴, Lingyun Sun⁵ and Jiangsu Lupus Collaborative Group, ¹Department of Rheumatology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Huaian First People’s Hospital, Huaian, China, ³Xuzhou No. 4 People’s Hospital, Xuzhou, China, ⁴the 3rd Affiliated Hospital of Suzhou University, Changzhou, China, ⁵the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: To find out prognostic factors predicting the outcome of Chinese patients with systemic lupus erythematosus (SLE) at the time of their first admission. Methods: A…
Abstract Number: 2027 • 2016 ACR/ARHP Annual Meeting
The Association of Light and Moderate-to-Vigorous Walking with Incident Poor Health Outcomes over Two Years in People with or at High Risk of Knee Osteoarthritis
Sally Fenton^1,2, Joan Duda³, Rainer Klocke⁴, Abishek Abishek⁵, Alison Rushton³, Michael Doherty⁶, Weiya Zhang⁷, George D. Kitas², Tuhina Neogi⁸, Michael Nevitt⁹, Cora E Lewis¹⁰, James Torner¹¹, Dorothy D. Dunlop¹² and Daniel White¹³, ¹School of Sport, Exercise and Rehabilitation, University of Birmingham, Birmingham, United Kingdom, ²Department of Rheumatology, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ³School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, UK, Birmingham, United Kingdom, ⁴Rheumatology Department, The Dudley Group of Hospitals NHS Foundation Trust, Dudley, United Kingdom, ⁵Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom, ⁶University of Nottingham, Nottingham, United Kingdom, ⁷Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham, Nottingham, United Kingdom, ⁸Clinical Epidemiology, Boston University School of Medicine, Boston, MA, ⁹Department of Epidemiology & Biostatistics, University of California San Francisco School of Medicine, San Francisco, CA, ¹⁰Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, ¹¹University of Iowa, UIowa, Iowa City, IA, ¹²Center for Healthcare Studies, Northwestern University Feinberg School of Medicine, Chicago, IL, ¹³Department of Physical Therapy, University of Delaware, Newark, DE
Background/Purpose: Regular engagement in physical activity reduces the risk adverse health outcomes such as cardiovascular diseases, functional limitation, and depression in people with knee osteoarthritis…
Abstract Number: 584 • 2015 ACR/ARHP Annual Meeting
Positivity for Rheumatoid Factor Is Associated with a Better Short-Term Response and Long-Term Drug Retention of Abatacept: Results from Consecutive 508 Patients with Rheumatoid Arthritis in a Japanese Multicenter Registry
Nobunori Takahashi¹, Toshihisa Kojima¹, Koji Funahashi² and Naoki Ishiguro³, ¹Department of Orthopedic Surgery, Nagoya University Hospital, Nagoya, Japan, ²Nagoya University Hospital, Nagoya, Japan, ³Department of Orthopedic Suregery, Nagoya University Hospital, Nagoya, Japan
Background/Purpose: Abatacept (ABT) is a biologic drug and has been available for rheumatoid arthritis (RA) patients since 2010 in Japan. There have still been few…
Abstract Number: 3061 • 2015 ACR/ARHP Annual Meeting
Tocilizumab in Refractory Takayasu Arteritis. a Multicenter Study
Natalia Palmou¹, Montserrat Santos-Gómez^1,2, Javier Loricera¹, Ricardo Blanco¹, Jose L. Hernández³, Santos Castañeda⁴, Alicia Humbría⁵, Norberto Ortego-Centeno⁶, Beatriz Bravo⁷, Mercedes Freire^8,9, Sheila Melchor¹⁰, Mauricio Minguez¹¹, Juan Salvatierra¹², Carmen Gonzalez-Vela¹³, Vanesa Calvo-Río¹, Trinitario Pina¹ and Miguel Angel Gonzalez-Gay¹, ¹Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ²Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, ³Internal Medicine, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain, ⁴Rheumatology, H.U. La Princesa, Madrid, Spain, ⁵Rheumatology, Hospital Universitario de La Princesa. IIS-Princesa, Madrid, Madrid, Spain, ⁶Systemic Autoimmune Diseases Unit, Hospital Universitario San Cecilio, Granada, Spain, ⁷Pediatric rheumatology, Hospital Virgen de las Nieves, Granada, Spain, ⁸Rheumatology, Hospital Universitario Juan Canalejo, La Coruña, Spain, ⁹Rheumatology, Complejo Hospitalario Universitario de A Coruña, La Coruna, Spain, ¹⁰Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, ¹¹Department of Rheumatology, Hospital Universitario San Juan, Alicante, Spain, ¹²Rheumatology, University Hospital San Cecilio, Granada, Spain, ¹³Pathology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Santander, Spain
Background/Purpose: Takayasu arteritis (TA) is often refractory to corticosteroids and traditional immunosuppressive agents. Interleukin (IL)-6 plays an important role in the pathogenesis of TA. Tocilizumab…
Abstract Number: 910 • 2014 ACR/ARHP Annual Meeting
The Selective Sphingosine-1- Phosphate Receptor 1/5 Modulator Siponimod (BAF312) Shows Beneficial Effects in Patients with Active, Treatment Refractory Polymyositis and Dermatomyositis: A Phase IIa Proof-of-Concept, Double-Blind, Randomized Trial
Katalin Danko¹, Jiri Vencovsky², Ingrid E. Lundberg³, Anthony A Amato⁴, Chester V. Oddis⁵, Maria Molnar⁶, Antonette Mallari Moher⁷, Laurence Colin⁸, Florian Muellershausen⁹, David Lee¹⁰ and Peter Gergely⁹, ¹Institute of Rheumatology, University of Debrecen, Hungary, Debrecen, Hungary, ²Institute of Rheumatology, Charles University, Prague, Czech Republic, ³Rheumatology Unit, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, ⁴Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ⁵Rheum/Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ⁶Institute of Genomic Medicine and Rare Disorders, Semmelweis University, Budapest, Hungary, ⁷Translational Medicine, Novartis Institutes for Biomedical Research (former emplyee), Basel, Switzerland, ⁸Novartis Pharma, Basel, Switzerland, ⁹Translational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland, ¹⁰Novartis Pharmaceuticals Corporation, Basel, Switzerland
Background/Purpose Polymyositis and dermatomyositis (PM/DM) comprise a heterogeneous group of chronic inflammatory muscle diseases where infiltration of lymphocytes in the skeletal muscle plays a key…
Abstract Number: 2550 • 2012 ACR/ARHP Annual Meeting
Clinical, Radiographic, and Immunogenic Effects After 1 Year of Tocilizumab-Based Treatment Strategy with and without Methotrexate in Rheumatoid Arthritis: The ACT-RAY Study
Maxime Dougados¹, Karsten Kissel², Philip G. Conaghan³, Emilio Martin-Mola⁴, Georg A. Schett⁵, Howard Amital⁶, Ricardo M. Xavier⁷, OM Troum⁸, Corrado Bernasconi⁹ and T.W.J. Huizinga¹⁰, ¹Rheumatology B Department, Paris-Descartes University, APHP, Cochin Hospital, Paris, France, ²F. Hoffmann-La Roche Ltd, Basel, Switzerland, ³University of Leeds, Leeds, United Kingdom, ⁴Rheumatology, Hospital Universitario La Paz, Madrid, Spain, ⁵Dept of Medicine 3, Rheumatology and Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, ⁶Sheba Medical Center, Tel-Hashomer, Israel, ⁷Rheumatology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil, ⁸Medicine, USC Keck School of Medicine, Santa Monica, CA, ⁹Consultant, Basel, Switzerland, ¹⁰Rheumatology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: 24-week data from ACT-RAY comparing an add-on strategy (tocilizumab [TCZ] + methotrexate [MTX]) with a switch strategy (TCZ + placebo [PBO]) in MTX-IR patients…
Abstract Number: 1406 • 2012 ACR/ARHP Annual Meeting
The Cost of Management of Adult Active Systemic Lupus Erythematosus in the UK
Munther A. Khamashta¹, Christina Donatti², Ian N. Bruce³, Caroline Gordon⁴, David A. Isenberg⁵ and Ateka-Barrutia Oier⁶, ¹Lupus Research Unit, The Rayne Institute, St Thomas Hospital, Kings College London School of Medicine, London, United Kingdom, ²Health Economics and Outcomes Research, IMS Health, United Kingdom, ³Manchester Academic Health Science Centre, Arthritis Research UK Epidemiology Unit and NIHR Manchester Musculoskeletal Biomedical Research Unit, The University of Manchester, Manchester, United Kingdom, ⁴Rheumatology Research Group (East Wing), School of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom, ⁵Centre for Rheumatology Research, Rayne Building, 4th Floor, Centre for Rheumatology, Department of Medicine, University College London, London, United Kingdom, ⁶Lupus Research Unit, The Rayne Institute, Kings College London School of Medicine, London, United Kingdom
Background/Purpose: Several international studies have shown that systemic lupus erythematosus (SLE) has a considerable financial burden on patients and the health-care economy. Little recent information…

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