Abstracts tagged "mucosal T cells and systemic lupus erythematosus (SLE)"

Abstract Number: 1065 • 2017 ACR/ARHP Annual Meeting
Mucosal-Associated Invariant T Cell Deficiency in Systemic Lupus Erythematosus Is Realted to an Intrinsic Defect in the Ca2+/Calcineurin/NFAT1 Signaling Pathway
Yong-Wook Park¹, Young-Nan Cho², Hye-Mi Jin¹, Tae-Jong Kim³ and Seung-Jung Kee⁴, ¹Rheumatology, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South), ²Rheumatology, Chonnam National University Hospital and Medical School, Gwangju, MN, Korea, Republic of (South), ³Chonnam Nat`l University Medical School&Hospital, Chonnam, Korea, Republic of (South), ⁴Laboratory Medicine, Chonnam National University Medical School and Hospital, Gwangju, Korea, Republic of (South)
Background/Purpose: Mucosal-associated invariant T (MAIT) cells contribute to protection against certain microorganism infections and play an important role in mucosal immunity. However, the role of…
Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting
Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous
Goh Murayama¹, Asako Chiba², Ken Yamaji³, Naoto Tamura³, Yoshinari Takasaki³ and Sachiko Miyake², ¹Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, ²Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 2728 • 2014 ACR/ARHP Annual Meeting
Reduction of MAIT Cell Frequency Associated with Reduced Cell Proliferation and Enhanced Cell Death in Systemic Lupus Erythematosus
Asako Chiba¹, Naoto Tamura², Eri Hayashi², Ran Matsudaira³, Yoshinari Takasaki⁴ and Sachiko Miyake¹, ¹Immunology, Juntendo University School of Medicine, Tokyo, Japan, ²Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan, ⁴Department of Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes which are restricted by the MHC-related molecule-1 (MR1) and express a semi-invariant TCRα chain: Vα7.2-Jα33 in…

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