Abstracts tagged "mucosal barriers and rheumatoid arthritis (RA)"

Abstract Number: 65 • ACR/ARHP Annual Meeting 2018
Bacteria-Derived Indole Drives Autoimmune Arthritis By Altering B Cell Glycosylation of Autoantibodies
Widian Jubair¹, Erica Alexeev², Timothy Lemke³, Meagan Chriswell¹, Sean Colgan² and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO, ³University of Colorado Denver, Aurora, CO
Background/Purpose: Ongoing studies in rheumatoid arthritis (RA) implicate intestinal dysbiosis of bacteria as a contributing factor, though the mechanism(s) by which bacteria influence disease is…
Abstract Number: 67 • ACR/ARHP Annual Meeting 2018
Intestinal Inflammation and Netosis Associate with the Presence of Stool IgA ACPA in Subjects at-Risk for RA
Widian Jubair¹, Elizabeth A. Bemis², Yuko Okamoto³, Marie L. Feser³, Jennifer Seifert³, M. Kristen Demoruelle³, Jill M. Norris⁴, Kevin D. Deane³, V. Michael Holers⁵ and Kristine A Kuhn^1,6, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Epidemiology, Colorado School of Public Health, Aurora, CO, ³Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁴Department of Epidemiology, Colorado School of Public Health, Aurora, CO, ⁵Rheumatology Division, University of Colorado Denver, Aurora, CO, ⁶Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Anti-citrullinated protein antibodies (ACPA) and inflammation characterized by neutrophil extracellular trap (NET)osis have been detected at mucosal sites such as the lung and periodontium…
Abstract Number: 450 • ACR/ARHP Annual Meeting 2014
The Mucosal Anti-Citrullinated Protein Antibody Response in Pre-Clinical Rheumatoid Arthritis
Anneke van der Horst¹, Ivy Y.K. Choi², Dirkjan van Schaardenburg³, D.M Gerlag², Paul Tak², Dörte Hamann¹ and Rogier M. Thurlings², ¹Sanquin Diagnostic Services, Amsterdam, Netherlands, ²Clinical Immunology & Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ³Dr Jan van Breemenstraat 2, Reade, Amsterdam, Netherlands
Background/Purpose Recent data suggest rheumatoid arthritis (RA) may originate from an autoimmune response in inflamed mucosa. RA is associated with gingival and airway inflammation and…