Abstracts tagged "mTORC1"

Abstract Number: 60 • 2019 ACR/ARP Annual Meeting
mTORC1-phosphorylated CXCR3+memory B Cells and Their Potential as a New Mode of Action of TNF Inhibitors in RA
Shigeru Iwata¹, Mingzeng Zhang ¹, Maiko Hajime ¹, Naoaki Ohkubo ¹, Yukihiro Kitanaga ¹, Gulzhan Trimova ¹, Kazuhisa Nakano ², Shingo Nakayamada ¹, Kaoru Yamagata ¹, Kei Sakata ¹ and Yoshiya Tanaka ³, ¹The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, Japan, ²The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan, Kitakyushu, ³University of Occupational and Environmental Health Japan, Kitakyushu, Japan
Background/Purpose: B cells play a crucial role through producing autoantibodies and activating osteoclasts in synovium in rheumatoid arthritis (RA). Recently “Immunometabolism” attract much attention, and…