ACR Meeting Abstracts

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Abstracts tagged "Mouse Models, Lupus"

  • Abstract Number: 0091 • ACR Convergence 2024

    Targeting Endothelial Dysfunction in Lupus Nephritis: Effect of Sepiapterin, a Drug That Restores Endothelial Nitric Oxide Synthase Function, in a Murine Model of Lupus Nephritis

    Dayvia Russell1, Sandra Mungaray2, Soroush Moradi2 and Jim Oates2, 1Ralph H. Johnson VA, Charleston, SC, 2Medical University of South Carolina, Charleston, SC

    Background/Purpose: Lupus nephritis (LN) is characterized by chronic endothelial cell dysfunction (ECD), which occurs when endothelial nitric oxide synthase (eNOS) becomes uncoupled, producing harmful reactive…
  • Abstract Number: 0092 • ACR Convergence 2024

    A New Generation Mesenchymal Stromal Cell (MSC)-based Cell Therapy Using Design of Experiments Halts Pristane Induced Glomerulosclerosis

    Hulya Bukulmez1, Adrienne Dennis2, kristine Highland3 and Steven N. Emancipator4, 1MetroHealth Medical Center, Case Western Reserve, Pepper Pike, OH, 2MetroHealth Medical Center, Case Western Reserve, Cleveland, OH, 3Cleveland Clinic Foundation, Cleveland, OH, 4Case Western Reserve University, Cleveland, OH

    Background/Purpose: MSCs, exposed to a disease-specific cytokine profile, can accurately sense the composition of the inflammatory microenvironment. We have harnessed this adaptive ability of MSCs…
  • Abstract Number: 0095 • ACR Convergence 2024

    Expansion of Brain T Cell Subsets Outside of the Choroid Plexus in Murine Models of Neuropsychiatric Manifestations of Systemic Lupus Erythematosus

    Minjung Kim1, Cecilia Stumpf2, Hadijat Makinde1, Mohammad Khan1, Vanessa Rodriguez2, Tyler Therron2, Jeremy Tilstra3, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3University of Pittsburgh, Pittsburgh, PA, 4Northwestern University, Skokie, IL

    Background/Purpose: Unclear mechanisms underlying diffuse NPSLE (psychosis, anxiety disorder, cognitive dysfunction) may lead to the devastating impact of this disease on patients’ health-related quality-of-life, representing…
  • Abstract Number: 0096 • ACR Convergence 2024

    Simultaneous Contribution of Brain-Intrinsic and Peripheral Disease Mechanisms to Neuropsychiatric Symptoms of Systemic Lupus Erythematosus (NPSLE)

    Hadijat Makinde1, Mohammad Khan1, Cecilia Stumpf2, Yidan Wang3, Tyler Therron2, Margaret Goldman2, Deborah Winter4 and Carla Cuda1, 1Northwestern University, Chicago, IL, 2Northwestern University, Chicago, 3Northwestern University, Hanover Park, IL, 4Northwestern University, Skokie, IL

    Background/Purpose: While NPSLE are among the least understood complications, increasing evidence points to microglia, a brain-resident innate immune cell population, as a driver of disease.…
  • Abstract Number: 0776 • ACR Convergence 2024

    Follicular Dendritic Cell PD-L1 Expression Promotes Autoreactive Germinal Center Formation

    Elliot Akama-Garren1, Yingying Zhang2, Balthasar Heesters3, Padraic Fallon4 and Michael Carroll2, 1Harvard Medical School, Boston, MA, 2Boston Children's Hospital, Boston, MA, 3Utrecht University, Utrecht, Netherlands, 4Trinity College Dublin, Dublin, Ireland

    Background/Purpose: Germinal center (GC) responses generate humoral immunity through coordinated interactions between B cells and T follicular helper (TFH) and T follicular regulatory (TFR) cells.…
  • Abstract Number: 1646 • ACR Convergence 2024

    A Novel E3 Ligase of GILZ: Validation of a Steroid-sparing Therapeutic Target in SLE

    Iolanda Miceli1, Rochelle Sherlock2, Pamela Hall2, IanIan Cheang2, Akshay D'Cruz3, Taylah Bennett2, Terry Lim Kam Sian2, Rangi Kandane-Rathnayake4, Eric Morand5 and Sarah Jones2, 1Monash University, Glen Iris, Victoria, Australia, 2Monash University, Melbourne, Australia, 3Monash University, Me, Australia, 4Monash University, Clayton, Victoria, Australia, 5School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia

    Background/Purpose: SLE is primarily mediated by B cell dysregulation on a background of type I interferon (IFN) activation. This multi-faceted nature of immune defects in…
  • Abstract Number: 1650 • ACR Convergence 2024

    IL-33 Expands Plasma Cells, Disrupts Germinal Centers and Increases Autoantibody Production

    Andre Limnander1, Eva Conde1, Seblewongel Asrat2, Andrea Vecchione2, Kaitlyn Gayvert2, Paulina Pedraza2, Carley Tasker2, Sharon Huang2, Dmitry Yarilin2, Dylan Birchard2, Li-Hong Ben2, Wei Keat Lim2, Andrew Murphy2, Matthew Sleeman2 and Jamie orengo1, 1Regeneron Pharmaceuticals, Tarrytown, NY, 2Regeneron Pharmaceuticals, Tarrytown

    Background/Purpose: IL-33 is a pro-inflammatory cytokine that plays a role in asthma, COPD and autoimmune diseases. The role of IL-33 on B cell maturation and…
  • Abstract Number: 1796 • ACR Convergence 2024

    Kidney Hematopoietic Stem and Progenitor Cells Contribute to Immune Cell Development and Pathology in Lupus Nephritis

    Hansol Yi1, Seyoung Jung2, Mi-Ra Cho3, Yong-Gil Kim1, Chang-Keun Lee1, Bin Yoo1, Jeongseok Lee2 and Seokchan Hong1, 1Asan medical center, Seoul, Republic of Korea, 2Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea, 3Asan medical center, University of Ulsan College of Medicine, Seoul, Republic of Korea

    Background/Purpose: Hematopoiesis primarily occurs in the bone marrow (BM), where hematopoietic stem and progenitor cells (HSPCs) originate. However, non-lymphoid tissues outside the BM can contribute…
  • Abstract Number: 1839 • ACR Convergence 2024

    PPP2R3C Overexpression Suppresses TCR -mediated CD4+ T Cell Abnormal Activation in Systemic Lupus Erythematosus via JNK and AKT-mTOR Pathways

    Xuan Fang, Xiangpei Li and Xiaomei Li, The First Affiliated Hospital of University of Science and Technology of China., He Fei, China (People's Republic)

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is distinguished by immune system dysfunction, leading to heightened activation of T and B cells. This increased activity leads to…
  • Abstract Number: 2437 • ACR Convergence 2024

    Aryl Hydrocarbon Receptor as an Intrinsic Novel Checkpoint That Inhibits TLR7-induced B-cell Activation in SLE

    Changming Lu1, Jose Rubio2, Hui-Chen Hsu1 and John D. Mountz3, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham, Hoover, AL, 3University Alabama Birmingham, Birmingham, AL

    Background/Purpose: Systemic lupus erythematosus (SLE) is characterized by an increase in T-bet+ IgD−CD27− double negative 2 (DN2) B cells, attributed to heightened TLR7 signaling. Identifying…
  • Abstract Number: 2545 • ACR Convergence 2024

    Phosphodiesterase 1B Contributes to Neuropsychiatric Manifestations in Lupus-Prone Mice Through Microglial Activation

    Shuhei Takeyama1, Michihito Kono1, Kohei Karino1, Yuki Kudo1, Masatoshi Kanda2, Hiroyuki Nakamura2, Kenichi Miyamoto1, Kazuro Kamada3, Maria Tada1, Ryo Hisada1, Yuichiro Fujieda1, Masaru Kato1, Olga Amengual4 and Tatsuya Atsumi1, 1Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapporo, Japan, 2Department of Rheumatology and Clinical Immunology, Sapporo Medical University, Sapporo, Japan, Sapporo, Japan, 3Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan, Sapprp, Japan, 4Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan

    Background/Purpose: Neuropsychiatric systemic lupus erythematosus (NPSLE) is one of the most severe organ manifestations in SLE and is associated with poor quality of life. We…
  • Abstract Number: 2547 • ACR Convergence 2024

    Neurophysiological Phenotypes Are Uncoupled from Toll-like Receptor-Mediated Peripheral Disease in a Mouse Model of Neuropsychiatric Symptoms of Systemic Lupus Erythematosus

    Cecilia Stumpf1, Vanessa Rodriguez1 and Carla Cuda2, 1Northwestern University, Chicago, 2Northwestern University, Chicago, IL

    Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical presentations, including neuropsychiatric symptoms (NPSLE). Despite being a major cause of morbidity…
  • Abstract Number: 2549 • ACR Convergence 2024

    VISTA Deficiency Alters the Skin Immune Cell Composition and Confers Skin Sensitivity to UV Light

    Zachary Peters1, Lindsay Mendyka2, Angelique Cortez1, J'voughnn Blake1, Alecia Roy1, William Rigby3, Christopher Burns4, Randolph Noelle5 and Sladjana Skopelja-Gardner6, 1Dartmouth College, Lebanon, NH, 2Dartmouth Hitchcock Memorial Hospital, Lyme, NH, 3Dartmouth-Hitchcock, Norwich, VT, 4Dartmouth Hitchcock Medical Center, Lebanon, NH, 5Geisel School of Medicine at Dartmouth, Lebanon, 6Dartmouth Geisel School of Medicine, Lebanon, NH

    Background/Purpose: Persistent production of type I interferons (IFN-Is) is one of the hallmarks of cutaneous lupus erythematosus (CLE) that is exacerbated by ultraviolet (UV) light.…
  • Abstract Number: 2550 • ACR Convergence 2024

    Infiltrating and Resident Macrophages in Lupus Nephritis: Scar Associated Macrophage Phagocytic Dysfunction and Fibroblast Activation

    Chirag Raparia1, Paul Hoover2, Arnon Arazi3, Nir Hacohen4 and Anne Davidson5, 1Donald and Barbara Zucker School of Medicine At Hofstra/Northwell, Shoreham, NY, 2Brigham and Women's Hospital, SWAMPSCOTT, MA, 3Feinstein Institutes for Medical Research, Melrose, MA, 4Broad Institute of MIT and Harvard, Boston, MA, 5Feinstein Institutes for Medical Research, Manhasset, NY

    Background/Purpose: Lupus nephritis (LN) is driven by a heterogeneous population of renal macrophages. We have previously reported that the renal macrophage subpopulations are similar in…
  • Abstract Number: 0007 • ACR Convergence 2024

    Bromodomain 2 of BET Proteins Plays a Crucial Role in Follicular/peripheral Helper T Cell and Plasma Cell Differentiation

    Ryota Sato1, Mitsuhiro Akiyama2, Koichi Oshita3, Yuko Kawano3, Yuki Imura3, Piruzyan Mariam4, Manami Kikuchi3, Mikako Murase3, Sachiko Mochiduki3, Naohiro Hashimoto3, Masayuki Watanabe3, Keiko Yoshimoto5, Tsutomu Takeuchi6, Kenji Chiba7 and Yuko Kaneko5, 1Mitsubishi Tanabe Pharma Corporation, Brighton, MA, 2Keio University School of Medicine, Palo Alto, CA, 3Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan, 4Mitsubishi Tanabe Pharma Corporation, Yokohama, Kanagawa, Japan, 5Keio University School of Medicine, Tokyo, Japan, 6Department of Internal Medicine, Keio University, Tokyo, Tokyo, Japan, 7Mitsubishi Tanabe Pharma Corporation, Tokyo, Japan

    Background/Purpose: Proteins motifs bromodomain 1 (BD1) and BD2 within the BET family proteins regulate gene expression of inflammatory cytokines and lymphocyte proliferation by binding to…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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