Abstracts tagged "Mouse model"

Abstract Number: 1015 • 2015 ACR/ARHP Annual Meeting
Contribution of TNF and Type I Interferon to the Development of Persistent Post-Inflammatory Mechanical Allodynia in Arthritic Mice
Sarah Woller¹, Cody Ocheltree², Tony Yaksh¹ and Maripat Corr², ¹Anesthesiology, UCSD, La Jolla, CA, ²Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Male C57Bl/6 (WT) mice develop transient inflammation in response to K/BxN serum transfer and show a corresponding pain state, which persists beyond the resolution…
Abstract Number: 1428 • 2015 ACR/ARHP Annual Meeting
Subchondral Bone Structure and Pain Behaviors in Complete Freund’s Adjuvant (CFA) Monoarthritis in Mice Treated with Intra-Articular (IA) Neurotoxin
Hollis E. Krug^1,2, Joseph Bert³, Fakhar Abbass⁴, Christopher W. Dorman⁵, Sandra Frizelle⁵ and Maren L. Mahowald^1,2, ¹Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ²Medicine, University of Minnesota, Minneapolis, MN, ³Internal Medicine, Division of Rheumatology, University of Minnesota, Minneapolis, MN, ⁴Minneapolis VA Health Care System, Minneapolis, MN, ⁵Research, Minneapolis VA Health Care System, Minneapolis, MN
Background/Purpose: Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis (AIA) in rats. We produced painful inflammatory monoarthritis in mouse knees with IA…
Abstract Number: 1431 • 2015 ACR/ARHP Annual Meeting
Age and Sex Impacts the Development of Hypersensitivity in the Murine Partial Medial Menisectomy Model of Osteoarthritis
Ada Delaney¹, Azar Barharpoor¹, Tianle Gao¹, Jie Su¹, NIlesh Agalave¹ and Camilla Svensson², ¹Dept. of Physiology & Pharmacology, Karolinska Institutet, Stockholm, Sweden, ²Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
Background/Purpose: Osteoarthritis (OA) is the leading cause of chronic pain in European adults (37%; painineurope.com). Pain is the foremost symptom of OA, with both episodes…
Abstract Number: 1766 • 2015 ACR/ARHP Annual Meeting
HPV Vaccination of Nzbxw/F1 Mice
Maria Teresa Arango¹, Lucija Tomljenovic², Miri Blank¹ and Yehuda Shoenfeld³, ¹Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel, ²University of British Columbia, Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, Vancouver, BC, Canada, ³Sheba Medical Center, Zabludowicz Center for Autoimmune Diseases, affiliated to affiliated to Sackler Faculty of Medicine, Tel-Aviv University, Ramat Gan, Israel
Background/Purpose: Human-papilloma virus vaccine (HPVv) is currently used worldwide. Still this vaccine has been linked to a variety of neurological and autoimmune manifestations. For instance,…
Abstract Number: 2086 • 2015 ACR/ARHP Annual Meeting
Inhibition of Macrophage Inflammatory Protein 1-Alpha (CCL3) Significantly Reduced Bone Resorption in Vitro and the Development of Erosive Joint Pathology in Collagen-Induced Arthritis
Lauren A. Jordan¹, Ruth Davies¹, Alastair J. D. Robertson², Ann K. Harvey¹, Ernest H. Choy¹, Malin Erlandsson³, Maria I. Bokarewa⁴, Rachel J. Errington¹ and Anwen S. Williams¹, ¹Cardiff University, Institute of Infection and Immunity, Tenovus Building, University Hospital of Wales, Cardiff, United Kingdom, ²William Harvey Hospital, Willesborough, Ashford, United Kingdom, ³University of Goteborg, Goteborg, Sweden, ⁴Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden
Background/Purpose: The destruction of bone is a common feature of diseases like rheumatoid arthritis (RA) and multiple myeloma (MM). CCL3 is significantly elevated in the…
Abstract Number: 2087 • 2015 ACR/ARHP Annual Meeting
Defective Circadian Control in Mesenchymal Cells Reduces Adult Bone Mass
Julia F. Charles¹ and Joerg Ermann², ¹Rheumatology, Allergy and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Genetic disruption of the circadian molecular clock in mice is a powerful tool to dissect the role of circadian rhythms in health and disease.…
Abstract Number: 3008 • 2015 ACR/ARHP Annual Meeting
Role of PTP4A1 Tyrosine Phosphatase in Systemic Sclerosis
Cristiano Sacchetti¹, Stephanie Stanford², Yunpeng Bai³, Zhong-Yin Zhang⁴, Amin Gholami⁵, Gregory Seumois⁶, Maria Piera-Velazquez⁷, Sergio A. Jimenez⁸ and Nunzio Bottini¹, ¹Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ²Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, ³Indiana University, School of Medicine, Indianapolis, IN, ⁴Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, ⁵Bioinformatics Core, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁶Sequencing Facility, La Jolla Institute for Allergy and immunology, La Jolla, CA, ⁷Dermatology and Cutaneous Biology, Jefferson Medical College, Philadelphia, PA, ⁸Div Connective Tissue Diseases, Thomas Jefferson Univ, Philadelphia, PA
Background/Purpose: Systemic sclerosis (SSc) is a multi-system autoimmune connective tissue disorder that leads to fibrosis of the skin and internal organs, resulting in significant patient…
Abstract Number: 2910 • 2014 ACR/ARHP Annual Meeting
Tofacitinib Facilitates the Expansion of Myeloid-Derived Suppressor Cells and Ameliorates Arthritis in SKG Mice
Keisuke Nishimura¹, Jun Saegusa¹, Fumichika Matsuki², Kengo Akashi¹, Goichi Kageyama¹ and Akio Morinobu¹, ¹Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ²Department of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Background/Purpose Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that are characterized by the co-expression of Gr1 and CD11b in mice. MDSCs suppress…
Abstract Number: 2364 • 2014 ACR/ARHP Annual Meeting
PET-CT Imaging of Joints: A Quantitative Tool for Developing Novel Anti-Inflammatory Drugs
Siba Raychaudhuri¹, Anupam Mitra², Smriti K. Raychaudhuri³ and Abhijit Chaudhari⁴, ¹Med/Rheumatology, Univ California Davis/VA Sac, Davis, CA, ²Dermatology, VA Sacramento Medical Center, Mather, CA, ³Rheumatology, VA Sacramento Medical Center, Mather, CA, ⁴Radiology, UC Davis School of Medicine, Sacramento, CA
Background/Purpose: Mouse collagen induced arthritis (CIA) is the most commonly used preclinical model to screen new drug candidates for inflammatory arthritis. The conventional read out…
Abstract Number: 653 • 2014 ACR/ARHP Annual Meeting
Dermal Injury Promotes Nephritis Flare in Lupus-Prone NZM2328 Mice
Kaitlyn Clark¹, Tamra J. Reed¹, Jeffrey B. Hodgin² and J. Michelle Kahlenberg³, ¹Internal Medicine, Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Pathology, University of Michigan, Ann Arbor, MI, ³Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI
Background/Purpose: Systemic lupus erythematosus is an autoimmune disease with pleotropic manifestations, including severe skin disease, hematologic abnormalities and nephritis. Clinically, lupus is characterized by episodes…
Abstract Number: 345 • 2014 ACR/ARHP Annual Meeting
A Low Salt Diet Ameliorates Clinical Manifestations in Collagen-Induced Arthritis
Bettina Sehnert¹, Sandy Pohle², Agnes Schröder³, Jens Titze^3,4 and Reinhard E. Voll⁵, ¹Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency,, University Hospital Freiburg, Freiburg, Germany, ²Department of Internal Medicine 3, University of Erlangen-Nürnberg, Erlangen, Germany, ³Interdisciplinary Center of Clinical Research, Research Group N2, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen-Nürnberg, Erlangen, Germany, ⁴Department of Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁵Rheumatology and Clinical Immunology & Centre of Chronic Immunodeficiency, University Hospital Freiburg, Freiburg, Germany
Background/Purpose A genetic predisposition, but also environmental factors including infections and smoking modulate manifestation and severity of inflammatory autoimmune disease like rheumatoid arthritis (RA). Recently,…
Abstract Number: 322 • 2014 ACR/ARHP Annual Meeting
Superior Therapeutic Efficacy of a Novel Oral Small Molecule Retinoic Acid Receptor-Related Orphan Receptor Gamma T [Rorgt] Inverse Agonist Inv-17: A Promising Safe & Efficacious Treatment for Rheumatoid Arthritis
Anderson Gaweco^1,2, Samantha Palmer¹, Rambon Shamilov¹, Caroline Stremnitzer¹, Katie Matthews¹, Michael Fisher¹, William Windsor¹, James Blinn¹, Ellen M. Ginzler³ and Jefferson Tilley¹, ¹Innovimmune Biotherapeutics, Brooklyn, NY, ²SUNY-Downstate Medical Center, Brooklyn, NY, ³Rheumatology, SUNY-Downstate Medical Center, Brooklyn, NY
Background/Purpose: T helper 17 [TH17] cells and its production of TH17 cytokines IL-17A and IL-17F play a critical role in the pathogenesis of RA and…
Abstract Number: 2859 • 2013 ACR/ARHP Annual Meeting
Pain Pathway Activation In Dorsal Root Ganglia and Dorsal Horn In a Murine Surgical Model Of Osteoarthritis
Rachel E. Miller¹, Phuong Tran², Richard J. Miller³ and Anne-Marie Malfait⁴, ¹Rheumatology/Biochemistry, Rush University Medical Center, Chicago, IL, ²Rheumatology, Rush University Medical Center, Chicago, IL, ³Molecular Biochemistry and Pharmacology, Northwestern University, Chicago, IL, ⁴Internal Medicine/Biochemistry, Rush University Medical Center, Chicago, IL
Background/Purpose: Using a surgical mouse model of osteoarthritis (OA), destabilization of the medial meniscus (DMM), we monitor pain and associated pathways over a period of…
Abstract Number: 2733 • 2013 ACR/ARHP Annual Meeting
Spontaneous Osteoarthritis In Mice By Genetic Deletion Of Nfatc1 and Nfatc2
Susan Y. Ritter¹, Matthew B. Greenblatt², Kelly Tsang¹, Dorothy Z. Hu³, John Wright⁴ and Antonios O. Aliprantis¹, ¹Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Pathology, Brigham and Women's Hospital, Boston, MA, ³Endocrine Unit, Massachusetts General Hospital, Boston, MA, ⁴Orthopedic Surgery, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Osteoarthritis (OA) was once viewed as a mechanical disease of “wear and tear”, but recent advances suggest that OA results from active dysregulation of…
Abstract Number: 2706 • 2013 ACR/ARHP Annual Meeting
Fli1 Haploinsufficiency Exacerbates Dermal Fibrosis Via Activation Of Fibroblasts, Endothelial Cells and Macrophages In Bleomycin-Treated Mice
Takashi Taniguchi¹, Yoshihide Asano¹, Kaname Akamata¹, Shinji Noda¹, Takehiro Takahashi¹, Yohei Ichimura¹, Tetsuo Toyama¹, Maria Trojanowska² and Shinichi Sato¹, ¹Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²Arthritis Center, Boston University, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disorder with clinical manifestations resulting from immune activation, vascular injuries and fibrosis development. Previous reports suggest that…

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