Abstracts tagged "Mouse model"

Abstract Number: 1991 • 2018 ACR/ARHP Annual Meeting
Measuring Balance in an Experimental Mouse Model of Osteoarthritis
Rachel E. Miller¹, Shingo Ishihara², Zhe Wang³, Richard J. Miller⁴ and Anne-Marie Malfait⁵, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Guangzhou Institutes of Biomedicine and Health, Guangzhou, China, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, ⁵Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Destabilization of the medial meniscus (DMM) in mice results in experimental osteoarthritis, characterized by progressive joint damage (severe damage by week 12) and associated…
Abstract Number: 53 • 2017 ACR/ARHP Annual Meeting
Poly-γ-Glutamic Acid Inhibits RANKL- Induced Osteoclast Differentiation and Prevents Bone Destruction in Rheumatoid Arthritis: Human and CIA Mouse Model
Bitnara Lee¹, Jong-Dae Ji² and Tae-Hwan Kim¹, ¹Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, Republic of (South), ²Rheumatology, Korea University Hospital, Seoul, Korea, Republic of (South)
Background/Purpose: Rheumatoid arthritis (RA) is an inflammatory disease that is characterized by chronic inflammation and bone destruction. Osteoclasts, which are bone-resorbing cells, are generally known…
Abstract Number: 860 • 2017 ACR/ARHP Annual Meeting
Effective Treatment of Persistent Arthritis Pain Requires Co-Modulation of TNF and Type I Interferon
Sarah Woller¹, Tony Yaksh² and Maripat Corr³, ¹Anesthesiology, UCSD, La Jolla, CA, ²Anesthesiology 0818, UCSD, La Jolla, CA, ³Division of Rheumatology, Allergy, and Immunology, UCSD, La Jolla, CA
Background/Purpose: Pain persisting beyond the resolution or control of clinical signs of rheumatoid arthritis (RA) decreases quality of life for millions of people. Unfortunately, this…
Abstract Number: 866 • 2017 ACR/ARHP Annual Meeting
Interferon-Alpha Overexpression Triggers an Expansion of Highly Suppressive Regulatory T Lymphocytes Protecting Against Experimental Arthritis
Matthieu Ribon^1,2, Katarzyna Matyja^2,3, Roxane Hervé^2,3, Delphine Lemeiter^2,3, François Santinon^2,3, Ken Tsumiyama⁴, Shunichi Shiozawa⁴, Marie-Christophe Boissier^3,5,6, Natacha Bessis^2,3 and Patrice Decker^2,3, ¹li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ²UMR 1125, INSERM, Bobigny, France, ³Li2P, University of Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁴Department of Medicine, Rheumatic Diseases Unit, Kyushu University Beppu Hospital, Beppu, Japan, ⁵Rheumatology Department, Assistance Publique – Hôpitaux de Paris (AP-HP), Avicenne Hospital, Bobigny, France, ⁶74 rue Marcel Cachin, INSERM, Bobigny, France
Background/Purpose: Type I interferons (IFN-I) can be both anti- and pro-inflammatory. Among them, IFN-α inhibits normal Th17 differentiation, whereas it is pathogenic in lupus. The…
Abstract Number: 2232 • 2017 ACR/ARHP Annual Meeting
A Role for CCR2 in Chronic Behavioral and Neuroimmune Changes in the DMM Model of Osteoarthritis
Phuong Tran¹, Shingo Ishihara², Rachel E. Miller³, Richard J. Miller⁴ and Anne-Marie Malfait¹, ¹Rheumatology, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Biochemistry, Rush University Medical Center, Chicago, IL, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL
Background/Purpose: The aim of this study was to explore pain-related behaviors and associated cellular changes in the pain pathway in experimental osteoarthritis (OA) induced by…
Abstract Number: 1850 • 2016 ACR/ARHP Annual Meeting
Optimization of a Murine Model to Recapitulate Dermal and Pulmonary Features of SSc
Tomoya Watanabe¹, Tetsuya Nishimoto², Jonathan Heywood³, Stanley Hoffman⁴, Logan Mlakar⁴ and Carol A. Feghali-Bostwick⁵, ¹Rheumatology, Medical University of South Carolina, Charleston, SC, ²Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Rheumataology, Medical University of South Carolina, Chareston, SC, ⁴Medical University of South Carolina, Charleston, SC, ⁵Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: The murine bleomycin (BLM)-induced fibrosis model is the most widely used in systemic sclerosis (SSc) studies. Traditionally, daily subcutaneous injections of BLM for 4-6…
Abstract Number: 1853 • 2016 ACR/ARHP Annual Meeting
Klf5+/-;Fli1+/- Mice Recapitulate Protracted Wound Healing and Cardiac and Intestinal Involvement Associated with Systemic Sclerosis
Kouki Nakamura¹, Yoshihide Asano², Takuya Miyagawa³, Megumi Hirabayashi³, Takashi Yamashita³, Ryosuke Saigusa¹, Shunsuke Miura², Tetsuo Toyama^3,4, Takehiro Takahashi¹, Yohei Ichimura¹, Takashi Taniguchi¹, Ayumi Yoshizaki³, Maria Trojanowska⁴ and Shinichi Sato¹, ¹Dermatology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan, ²University of Tokyo Graduate School of Medicine, Tokyo, Japan, ³Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA
Background/Purpose: Systemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis. Although the most recognizable manifestation is skin disease, SSc can…
Abstract Number: 2137 • 2016 ACR/ARHP Annual Meeting
Subchondral Bone Structure and Pain Behaviors in Collagenase Induced Noninflammatory Monoarthritis in Mice
Hollis E. Krug^1,2, Christopher W. Dorman³, Sandra Frizelle³, Peter A. Valen^2,4 and Maren L. Mahowald^1,2, ¹Medicine, University of Minnesota Medical School, Minneapolis, MN, ²Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Bone histomorphometry can define OA changes in rodents and in Antigen-Induced arthritis in rats. We previously found that pain from inflammatory monoarthritis in mouse…
Abstract Number: 2139 • 2016 ACR/ARHP Annual Meeting
High Fat Diet Induced Longitudinal Metabolic Changes Contribute to Acceleration of Osteoarthritis in Mice
Poulami Datta¹, Yue Zhang^2,3, Alexa Parousis¹, Anirudh Sharma¹, Evgeny Rossomacha¹, Rajiv Gandhi¹, Jason Rockel¹ and Mohit Kapoor¹, ¹Toronto Western Research Institute, University Health Network, Toronto, ON, Canada, ²Toronto Western Hospital, Arthritis Program, University Health Network, Toronto, ON, Canada, ³The first clinical college, Harbin Medical University, Harbin, China
Background/Purpose: The contribution of metabolic changes induced by high fat diet (HFD) to OA is poorly understood. We sought to determine if diet regulates…
Abstract Number: 2788 • 2016 ACR/ARHP Annual Meeting
Suppression of IL-1 Signaling Ameliorates Dermatitis in a Murine Model of Systemic Lupus Erythematosus
Jeremy Tilstra¹, Sheldon Bastacky² and Mark Shlomchik³, ¹Rheumatology, Univ of Pittsburgh Medical Center, Pittsburgh, PA, ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Immunology, University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic Lupus Erythematosus (SLE) is a prototypical autoimmune disease defined by autoantibody production, immune dysregulation, and end-organ damage. Our laboratory previously showed that MyD88,…
Abstract Number: 367 • 2016 ACR/ARHP Annual Meeting
Microarray Analyses of Dorsal Root Ganglia for the Study of Pathways Contributing to Pain in Experimental Osteoarthritis
Rachel E. Miller¹, Shingo Ishihara², Delfien Syx³, Richard J. Miller⁴, Ana M. Valdes⁵ and Anne-Marie Malfait⁶, ¹Biochemistry, Rush University Medical Center, Chicago, IL, ²Internal Medicine, Rush University Medical Center, Chicago, IL, ³Ghent University, Ghent, Belgium, ⁴Pharmacology/Medical Humanities and Bioethics, Northwestern University, Chicago, IL, ⁵Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis, Nottingham, United Kingdom, ⁶Rheumatology, Rush University Medical Center, Chicago, IL
Background/Purpose: Destabilization of the medial meniscus (DMM) in the mouse knee results in slowly progressive joint damage, accompanied by pain-related behaviors. Secondary mechanical allodynia develops…
Abstract Number: 372 • 2016 ACR/ARHP Annual Meeting
Effect of Chronicity on Pain Behaviors in Collagenase Induced Non-Inflammatory Monoarthritis in Mice
Hollis E. Krug^1,2, Christopher W. Dorman³, Sandra Frizelle³, Peter A. Valen^2,4 and Maren L. Mahowald^1,2, ¹Medicine, University of Minnesota Medical School, Minneapolis, MN, ²Medicine, Minneapolis VA Health Care System, Minneapolis, MN, ³Research, Minneapolis VA Health Care System, Minneapolis, MN, ⁴Division of Rheumatology, University of Minnesota Medical School, Minneapolis, MN
Background/Purpose: Background/Purpose: Osteoarthritis pain remains a significant health problem due to a growing elderly population and the need for newer effective medical therapies. Osteoarthritis…
Abstract Number: 922 • 2016 ACR/ARHP Annual Meeting
Negative Regulation of IL-17 Receptor Signaling By Regnase-1 Limits Immunopathology in a Mouse Model of Psoriatic Skin Disease
Sarah L. Gaffen¹, Leticia Monin², Nicole Ward³, Johann Gudjonsson⁴, Abhishek Garg⁵, Alicia Mathers² and Pappachan Kolattukudy⁶, ¹Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ²University of Pittsburgh, Pittsburgh, PA, ³Case Western Reserve University, Cleveland, OH, ⁴Dermatology, University of Michigan, Ann Arbor, MI, ⁵Rheumatology/Clinical Immun, University of Pittsburgh, Pittsburgh, PA, ⁶University of Central Florida, Orlando, FL
Background/Purpose: IL-17 cytokines have emerged as drivers of autoimmunity. Indeed, the IL-17A-targeting antibody secukinumab (Cosentyx) was recently approved for treatment of plaque psoriasis, and shows…
Abstract Number: 1668 • 2016 ACR/ARHP Annual Meeting
Selective Inhibition of Tumor Necrosis Factor-α Receptor 2 (TNFR2) Activity Alleviates Psoriasiform Inflammation in Mouse Models
Unnikrishnan Chandrasekharan¹, Chad Braley², Jennifer Harvey³, Zeneng Wang¹, Paul DiCorleto⁴ and M. Elaine Husni⁵, ¹Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, OH, ²Department of Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH, ³Department of Cellular and Molecular, Cleveland Clinic, Cleveland, OH, ⁴Division of Research and Sponsored Programs, Kent State, kent, OH, ⁵Rheumatology, Cleveland Clinic Foundation, Cleveland, OH
Background/Purpose: Tumor necrosis factor-α (TNF) activates two receptors globally, TNFR1 and TNFR2. Neutralizing antibodies or soluble TNF receptors can inactivate TNF, blocking activity of both…
Abstract Number: 1846 • 2016 ACR/ARHP Annual Meeting
Cutaneous and Visceral Fibrosis Induced By Endothelial Cell-Specific Constitutive Activation of TGF-β1 Signaling in Mice
Peter J. Wermuth, Kellan R. Carney, Fabian A. Mendoza, Sonsoles Piera-Velazquez and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Microvascular damage is an early event in Systemic Sclerosis (SSc) pathogenesis and may represent the initiating stimulus for the subsequent establishment and progression of…

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