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Abstracts tagged "mouse model and vasculitis"

  • Abstract Number: 1861 • 2014 ACR/ARHP Annual Meeting

    The Role of Macrophage Migration Inhibitory Factor (MIF) and MIF Gene Polymorphisms in the Pathogenesis of Granulomatosis with Polyangiitis

    Antoine G. Sreih1, Rana Ezzeddine2, Juan Fan3, Lin Leng3, Simon Carette4, David Cuthbertson5, Gary S. Hoffman6, Nader A. Khalidi7, Carol A. Langford8, Carol McAlear9, Paul Monach10, Philip Seo11, Ulrich Specks12, Steven R. Ytterberg13, Peter A. Merkel14 and Richard Bucala15, 1Medicine/Division of Rheumatology, The University of Pennsylvania, Philadelphia, PA, 2Biostatistics, Bristol-Myers Squibb, Wallingford, CT, 3Yale University, New Haven, CT, 4Division of Rheumatology, University of Toronto, Toronto, ON, Canada, 5Department of Biostatistics, University of South Florida, Tampa, FL, 6Center for Vasculitis Care and Research, Cleveland Clinic Foundation, Cleveland, OH, 7Division of Rheumatology, St. Joseph’s Hospital, McMaster University, Hamilton, ON, Canada, 8Center for Vasculitis Care and Research, Cleveland Clinic, Cleveland, OH, 9Division of Rheumatology, Vasculitis Center, University of Pennsylvania, Philadelphia, PA, 10Rheumatology, Boston University, Boston, MA, 11Rheumatology Division, Johns Hopkins Vasculitis Center, Johns Hopkins University, Baltimore, MD, 12Frederichs Dr NW, Mayo Clinic, Rochester, MN, 13Division of Rheumatology, Mayo Clinic, Rochester, MN, 14Vasculitis Center, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA, 15Rheum/Dept of Int Med, Yale University School of Med, New Haven, CT

    Background/Purpose: Macrophage Migration Inhibitory Factor (MIF) is an immunoregulatory cytokine that may play a central role in the pathogenesis of granulomatous diseases. Two functional polymorphisms…
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