Abstracts tagged "mouse model and toll-like receptors"

Abstract Number: 2570 • 2015 ACR/ARHP Annual Meeting
Comparative Analysis of Collagen-Antibody Induced Arthritis and the Arthritis Inhibitory Potential of Specific ACPA in Two Mouse Subspecies Genetically Separated about One Million Years Ago
Christina Grimm¹, Bianka Marklein¹, Zoltan Konthur², Gerd Burmester¹ and Karl Skriner¹, ¹Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany, ²Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany
Background/Purpose: Rheumatoid arthritis (RA) is believed to be induced by environmental, genetic and immunological factors. Monoclonal Anti-citrullinated protein/peptide autoantibodies (ACPA) target different citrullinated proteins years…
Abstract Number: 564 • 2013 ACR/ARHP Annual Meeting
Role of TLR3 and dsRNA Hyper-Responsiveness in the Generation of the Lupus-Like Phenotype of New Zealand Black Congenic Mice
Gillian Minty¹, Nan-Hua Chang², Kieran Manion³, Yuriy Baglaenko¹, Evelyn Pau⁴ and Joan E. Wither⁵, ¹Immunology, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ²Genetics and Development, Toronto Western Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ³Immunology, University of Toronto, Toronto, ON, Canada, ⁴Toronto Western Hospital, University of Toronto, Toronto, ON, Canada, ⁵1E420/Div of Rheumatology, Toronto Western Research Institute, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada
Background/Purpose: New Zealand Black (NZB) mice develop a spontaneous lupus-like autoimmune disease, similar to human systemic lupus erythematosus. Genetic mapping studies have linked loci on…

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