ACR Meeting Abstracts

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Abstracts tagged "mouse model and systemic sclerosis"

  • Abstract Number: 1111 • 2018 ACR/ARHP Annual Meeting

    CBS004, a Novel Monoclonal Antibody Against Bdca-2 Inhibits TLR-Induced Activation of Human pDC in Vitro and In Vivo. a Novel Therapeutic Target for Systemic Sclerosis

    Clarissa Corinaldesi1, Yasser M El-Sherbiny2, Gemma Migneco3, Rebecca Ross1, Steve Holmes4, Clive McKimmie5 and Francesco Del Galdo1, 1Leeds Biomedical Research Centre and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, 3Institute of Cancer and Pathology, University of Leeds, Leeds, United Kingdom, 4Capella Biosciences, LTD, London, United Kingdom, 5Virus Host Interactions Team, Section of Infection and Immunity, University of Leeds, Leeds, United Kingdom

    Background/Purpose: Human plasmacytoid dendritic cells (pDCs) have been implicated in the pathogenesis of Systemic Sclerosis (SSc) through their ability to infiltrate the skin and secrete…
  • Abstract Number: 26 • 2017 ACR/ARHP Annual Meeting

    Single B Cell Analysis Revealed the Relationship Among the Cytokine Profile, Antibody Affinity, and Pathogenic Roles of Autoantigen-Reactive B Cells in Systemic Sclerosis

    Takemichi Fukasawa1, Ayumi Yoshizaki2, Satoshi Ebata1, Kouki Nakamura1, Ryosuke Saigusa1, Takashi Yamashita1, Yoshihide Asano3, Yutaka Kazoe4, Kazuma Mawatari4, Takehiko Kitamori4 and Shinichi Sato5, 1Dermatology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 2Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3Applied Chemistry, University of Tokyo, Graduate School of Medicine, Tokyo, Japan, 4Applied Chemistry, University of Tokyo, Graduate School of Engineering, Tokyo, Japan, 5Department of Dermatology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan

    Background/Purpose: Recent studies have indicated that B cells play critical roles in systemic autoimmunity and disease expression through various functions such as induction of the…
  • Abstract Number: 1845 • 2016 ACR/ARHP Annual Meeting

    TGF-β-Induced Tissue Fibrosis Is Abrogated in Mice Containing a Constitutive Genetic Deletion of Nox4 (Nox4 knockout)

    Peter J. Wermuth and Sergio A. Jimenez, Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA

    Background/Purpose: Excessive deposition of collagen and other connective tissue components in the skin and multiple internal organs is characteristic of Systemic Sclerosis (SSc). Besides the…
  • Abstract Number: 2150 • 2015 ACR/ARHP Annual Meeting

    Treatment with Abatacept Prevents Experimental Dermal Fibrosis and Induces Regression of Established Inflammation-Driven Fibrosis

    Matthieu Ponsoye1, Camelia Frantz2, Nadira Ruzehaji3, Muriel Elhai4, Barbara Ruiz1, Anne Cauvet1, Yannick Allanore5 and Jerome Avouac4, 1INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, 2Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 3INSERM U1016, Paris Descartes University, Paris, France, 4Rheumatology A department and INSERM U1016, Paris Descartes University, Cochin Hospital, Paris, France, 5Paris Descartes University, Rheumatology A department, Cochin Hospital, And Eular Scleroderma Trials And Research (EUSTAR) Board, Paris, France

    Background/Purpose: Early stages of systemic sclerosis (SSc) are characterized by inflammatory skin infiltrates mainly composed of activated T cells. Cytotoxic T-lymphocyte associated molecule-4 (CTLA-4) is…
  • Abstract Number: 3001 • 2014 ACR/ARHP Annual Meeting

    Targeting IL-6 By Both Passive or Active Immunization Strategies Prevents Inflammation-Driven Skin Fibrosis

    Jerome Avouac1, Lucille Desallais2, Maxime Fréchet3, Muriel Elhai3, Jean François Zagury2 and Yannick Allanore1, 1Paris Descartes University, Rheumatology A Department and INSERM U1016, Cochin Hospital, Paris, France, 2Chaire de Bioinformatique, Laboratoire Génomique, Bioinformatique et Applications, EA 4627, Conservatoire National des Arts et Métiers, Paris, France, 3INSERM U1016, Cochin Institute, Paris, France

    Background/Purpose: Interleukin 6 (IL-6) is a pleiotropic cytokine involved in inflammatory and autoimmune processes. Preliminary data have suggested that IL-6 might contribute to systemic sclerosis…
  • Abstract Number: 967 • 2014 ACR/ARHP Annual Meeting

    Mir-145 Protects Against Skin Fibrosis in Vivo by targeting TGF-β Signaling

    Serena Vettori1,2, Christian Beyer3, Matthias Brock1, Naoki Iwamoto1, Britta Maurer1, Michelle Trenkmann1, Astrid Jüngel1, Renate E. Gay1, Maurizio Calcagni4, Gabriele Valentini5, Steffen Gay1, Joerg H. W. Distler3 and Oliver Distler1, 1Center of Experimental Rheumatology, Zurich University Hospital, Zurich, Switzerland, 2Internal and Experimental Medicine, Second University of Naples, Naples, Italy, 3Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 4Division of Plastic Surgery and Hand Surgery, University Hospital Zurich, Zurich, Switzerland, 5Internal and Experimental Medicine, Second University of Naples, Napoli, Italy

    Background/Purpose In vitro, miR-145 exerts anti-fibrotic effects in systemic sclerosis (SSc) by downregulating TGF-β signaling. In turn, ectopic TGF-β downregulates miR-145 thereby optimizing TGF-β signaling…
  • Abstract Number: 2567 • 2013 ACR/ARHP Annual Meeting

    Cadherin-11 Regulates Pulmonary Fibrosis In Bleomycin-Induced Lung Injury

    Mesias Pedroza, Anuh T. George and Sandeep K. Agarwal, Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX

    Background/Purpose: Pulmonary fibrosis (PF) is the leading cause of death in systemic sclerosis.  Pathologically, PF is characterized by an aberrant wound healing repair mechanism leading…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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