Abstracts tagged "mouse model and phagocytosis"

Abstract Number: 3214 • 2015 ACR/ARHP Annual Meeting
Impaired Phagocytosis of Apoptotic Cells in Pristane-Induced Lupus Simulates the Clearance Defect in Human SLE
Shuhong Han¹, Haoyang Zuang¹, Ravil Khaybullin², Stepan Shumyak³, Anan Afaneh⁴, Xin Qi⁵, Lijun yang⁶ and Westley H. Reeves⁷, ¹Division of Rheumatology and Clinical Immunology, University of Florida, Gainesville, FL, ²medicinal chemistry, University of Flordia, gainesville, FL, ³division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁴Division of Rheumatology & Clinical Immunology, university of florida, gainesville, FL, ⁵medicinal chemistry, University of Florida, gainesville, FL, ⁶Pathology, Immunology & Laboratory Medicine, University of Florida, Gainesville, FL, ⁷Medicine, University of Florida, Gainesville, FL
Background/Purpose: Defective phagocytosis of dead cells is seen in SLE patients’ monocytes. Pristane-induced lupus causes accumulation of dead cells in tissues resembling that in SLE…

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