Abstracts tagged "mouse model and osteoarthritis"

Abstract Number: 52 • 2017 ACR/ARHP Annual Meeting
In Vivo Effect of Opticin Deficiency in a Surgically Induced Mouse Model of Osteoarthritis
Aina Farran¹, Gladys Valverde-Franco², Laura Tio³, Bertrand Lussier⁴, Hassan Fahmi², Jean-Pierre Pelletier², Paul Bishop⁵, Jordi Monfort⁶ and Johanne Martel-Pelletier², ¹Osteoarthritis Research Unit (CRCHUM), Montreal; Inflammation and Cartilage Cellular Research Group, IMIM (Hospital del Mar Research Unit) Rheumatology Department, Parc de Salut Mar, Hospital del Mar, Barcelona, Barcelona, Spain, ²Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ³Inflammation and Cartilage Cellular Research Group, IMIM (Hospital del Mar Research Unit) Rheumatology Department, Parc de Salut Mar, Hospital del Mar, Barcelona, Spain, ⁴Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM); Faculty of Veterinary Medicine, Clinical Sciences, University of Montreal, Sainte-Hyacinthe, QC, Canada, ⁵Manchester Royal Eye Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre; School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom, ⁶Inflammation and Cartilage Cellular Research Group, IMIM (Hospital del Mar Research Unit) Rheumatology Department, Parc de Salut Mar; Rheumatology Department, Hospital del Mar, Barcelona, Spain
Background/Purpose: Opticin (OPTC) is a small leucine-rich proteoglycan (SLRP) that has been previously demonstrated to be produced and degraded in osteoarthritic (OA) human cartilage. Here,…
Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting
Adipocytokines in an Osteoarthritis Mouse Model
Marie-Lisa Hülser¹, Carina Schreiyäck¹, Yubin Luo², Aline Bozec², Georg Schett³, Elena Neumann⁴ and Ulf Müller-Ladner⁵, ¹Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ²Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, ³Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, ⁴Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ⁵Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
Abstract Number: 2136 • 2016 ACR/ARHP Annual Meeting
CD14 Deficiency Delays Progression of Cartilage Degeneration and Protects Against Early Deficits in Functional Outcomes in a Murine Osteoarthritis Model
Nisha Sambamurthy^1,2, Vu Nguyen^1,2, Ryan Smalley^2,3, George R. Dodge^3,4 and Carla R. Scanzello^1,2,3, ¹Division of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ²Translational Musculoskeletal Research Center, CMC Veterans Affairs Medical Center, Philadelphia, PA, ³Department of Orthopedic Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, ⁴Research, CMC Veterans Affairs Medical Center, Philadelphia, PA
Background/Purpose: CD14, though expressed by multiple cell types, is highly expressed by monocytes and macrophages. It forms a complex with Toll-like receptors (TLRs), particularly TLR-2…
Abstract Number: 2011 • 2015 ACR/ARHP Annual Meeting
Disruption of the Molecular Clock in Mesenchymal Cells Causes an Osteoarthritis-like Disease in Mice
Joerg Ermann and Antonios Aliprantis, Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Tissue-intrinsic circadian molecular clocks control many physiological processes. The function of these clocks in cells of the musculoskeletal system and their contribution to disease…
Abstract Number: 73 • 2013 ACR/ARHP Annual Meeting
Fibrillin-1 Expression and Function Is Needed For Normal Joint Function and Mutations Leads To Osteoarthritis
Wasabha Ramanayake¹, Helen Jones¹, Isabel Orriss², Tim Arnett², Andrew Pitsillides³, Christopher P. Denton⁴, David J. Abraham⁴ and Blandine Poulet⁵, ¹Centre for Rheumatology and Connective tissue diseases, UCL Medical School, London, United Kingdom, ²Department of Cell and developmental biology, University College London, London, United Kingdom, ³Department of Comparative Biomedical Sciences, Royal Veterniary College, London, United Kingdom, ⁴Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, ⁵Centre for Rheumarology and connective tissue diseases, UCL Medical School, London, United Kingdom
Background/Purpose: Osteoarthritis (OA) is a common degenerative disease leading to pain and disability in >6million british people. The TGFb signalling pathway has been shown to…
Abstract Number: 50 • 2013 ACR/ARHP Annual Meeting
Cartilage Matrix Remodeling and Activation Of Canonical Wnt- Signaling Precedes Calcification and OA-Like Changes In Mice
Jessica Bertrand¹, Tabea Kräft², Yvonne Nitschke³, Thelonius Hawellek⁴, Jan Hubert⁴, Lars Godmann⁵ and Thomas Pap⁵, ¹Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ²Inst, University Hospital Münster, Muenster, Germany, ³University Hospital Münster, Muenster, Germany, ⁴University Hospital Hamburg, Hamburg, Germany, ⁵Institute of Experimental Muskuloskeletal Medicine, University Hospital Münster, Münster, Germany
Background/Purpose: Calcification of cartilage is a common finding during osteoarthritis (OA) and is directly linked to the severity of cartilage degradation. We have found in…

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