Abstracts tagged "Mortality"

Abstract Number: 1995 • ACR Convergence 2024
Use of Abatacept for the Treatment of Severe Immune-related Adverse Events from Immune Checkpoint Inhibitors for Cancer: A Case Series
Kaitlin McCarter¹, Xiaosong Wang², Senada Arabelovic¹, Nicole LeBoeuf¹, Elizabeth Buchbinder³, Lydia Gedmintas¹, Lindsey MacFarlane⁴, Deepak Rao⁵, Nancy Shadick², Elad Sharon³, Brittany Weber⁶, Anju Nohria¹, Ellen Gravallese⁷ and Jeffrey Sparks⁸, ¹Brigham and Women's Hospital, Boston, MA, ²Brigham and Women’s Hospital, Boston, MA, ³Dana Farber Cancer Institute, Boston, MA, ⁴Brigham and Women's Hospital, Hanover, NH, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶Brigham and Women's Hospital, DEDHAM, MA, ⁷Brigham and Women's Hospital, Harvard Medical School, Chestnut Hill, MA, ⁸Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA, Boston, MA
Background/Purpose: Immune checkpoint inhibitors (ICI) antagonize CTLA-4, PD-1, PD-L1, and Lag-3 to stimulate the immune system to treat cancer but may also cause immune-related adverse…
Abstract Number: 2456 • ACR Convergence 2024
High Levels of Circulating IFNα Are Associated with Increased Mortality in Patients with Diffuse Cutaneous Systemic Sclerosis
François Maillet¹, Carine Schmidt¹, Vincent Bondet², Alexandre Bense¹, Darragh Duffy³, Luc Mouthon¹, Mathieu Paul Rodero⁴ and Benjamin Chaigne⁵, ¹AP HP, Paris, France, ²INSERM PAsteur Institute, Paris, France, ³Inserm Pasteur Institue, Paris, France, ⁴Université Paris CIté, Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques, Faculté des Saint-Pères, Paris, France, ⁵Service de Médecine Interne, Centre de Référence Maladies Systémiques Autoimmunes et Autoinflammatoires Rares d'Ile de France de l’Est et de l’Ouest, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, Ile-de-France, France
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease characterized by skin and organ fibrosis, autoimmunity, and vasculopathy. Although its pathophysiology remains unclear, recent data…
Abstract Number: 0339 • ACR Convergence 2024
Clinical Characteristics Associated with Inpatient Mortality in Dermatomyositis Patients: A Single Center Retrospective Cohort Study
Anjana Srikumar, Keon Niknejad, Maria Kaltchenko and Jun Kang, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Dermatomyositis (DM) is a rare autoimmune disease associated with higher rates of hospitalization, longer lengths of stay, higher mean hospitalization costs, and increased inpatient…
Abstract Number: 0986 • ACR Convergence 2024
State-and-County-Level Social Vulnerability Index and Trends in Systemic Lupus Erythematosus-Related Mortality in the U.S
Omer Pamuk¹, Ansaam Daoud², Hasan Cetin³ and Marina Magrey⁴, ¹University Hospitals Cleveland Medical Center/ Case Western Reserve University, Cleveland, OH, ²Case Western Reserve University/University Hospitals, Akron, OH, ³Cleveland Clinic Cole Eye Institute, Cleveland, OH, ⁴Case Western Reserve University School of Medicine/University Hospitals, Richfield, OH
Background/Purpose: Epidemiological studies have shown significant health disparities in systemic lupus erythematosus (SLE). The Centers for Disease Control and Prevention (CDC) developed the social vulnerability…
Abstract Number: 2031 • ACR Convergence 2024
A Contemporary Assessment of the Burden of Malignancy in IgG4-Related Disease
Grace McMahon¹, Isha Jha¹, Guy Katz¹, Cory Perugino¹, Ana Fernandes¹, John Stone² and Zachary Wallace³, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hospital , Harvard Medical School, Concord, MA, ³Massachusetts General Hospital, Newton, MA
Background/Purpose: IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder that can affect nearly any organ. Because of the often tumefactive nature of IgG4-RD and its typical…
Abstract Number: 2467 • ACR Convergence 2024
Elderly Systemic Sclerosis. Clinical Presentation and Outcome
Miriam Retuerto Guerrero¹, Clara Moriano², cristiana sieiro santos³, Ismael Gonzalez⁴, Ignacio Gonzalez Fernandez⁵, Carolina Díez Morrondo⁵, Carolina Alvarez Castro⁶, Paula Perez Garcia⁵, Jose Ordas Martínez⁵, Pedro Baenas Gonzalez⁵ and elvira Diez álvarez⁵, ¹Complejo Asistencial Universitario de León, Leon, Spain, ²Hospital León, LEON, Spain, ³Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, ⁴Complejo Asistencial Universitario de Leon, León, Spain, ⁵Complejo Asistencial Universitario de Leon, Leon, ⁶Complejo Asistencial Universitario de Leon, Leon, Spain
Background/Purpose: Immunosenescence refers to the gradual deterioration of the immune system associated with aging, leading to an increased incidence of infections, cancer, and autoimmune diseases.…
Abstract Number: 0487 • ACR Convergence 2024
The Triglyceride to HDL Ratio, a Surrogate Marker of Insulin Resistance, Predicts All Cause and Cardiovascular Mortality in Rheumatoid Arthritis
Jose Felix Restrepo Suarez¹, Carlos Lorenzo¹, Inmaculada Del rincon² and Agustin Escalante¹, ¹UT Health San Antonio, San Antonio, TX, ²UT Health San Antonio, San Antonio
Background/Purpose: The triglyceride to HDL cholesterol (TG/HDL) ratio, a recognized surrogate marker of insulin resistance, has emerged as a predictor of cardiovascular (CV) risk. However,…
Abstract Number: 0998 • ACR Convergence 2024
Trends and Disparities in Cardiovascular Deaths in Systemic Lupus Erythematosus: A Population-Based Retrospective Study in the United States from 1999 to 2021
Faizan Ahmed¹, Shreyas Patil², Yash Deshpande³, Simran Bhimani³, Anand Maligireddy⁴, Leighton Hope⁵, Tehmasp Rehman Mirza⁶, Mohamed Abugrin⁷, Hardik Valand⁸, Chaitanya Rojulpote⁵ and karthik Gonuguntla⁹, ¹Ameer-ud-Din Medical College, Lahore, Pakistan, ²The Wright Center, Scranton, ³The Wright Center for Graduate Medical Education, Scranton, PA, ⁴The Wright Center, GME, Scranton, PA, ⁵Saint Louis University, St. Louis, MO, ⁶Department of Internal Medicine, Shalamar Medical and Dental College, Lahore, ⁷Bassett Medical Center, Cooperstown, ⁸Trinity Health System, Steubenville, OH, ⁹West Virginia University, Morgantown
Background/Purpose: This study aimed to analyze two decades of consecutive mortality data to investigate cardiovascular deaths in Systemic Lupus Erythematosus (SLE) across the United States…
Abstract Number: 2129 • ACR Convergence 2024
Fracture Risk Assessment Tool (FRAX®) Scores Predict Mortality in Community-Dwelling Elderlies
Thiago Quadrante Freitas¹, Leonardo Olalla², Luana Machado³, Camille Figueiredo³, Liliam Takayama⁴, Valeria Caparbo³, Ricardo Oliveira⁵, Diogo Domiciano¹ and Rosa M R Pereira³, ¹Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, ²Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Quito, Ecuador, ³Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil, ⁴Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil, ⁵RDO DIAGNÓSTICOS MÉDICOS, São Paulo, SP, Brazil
Background/Purpose: The World Health Organization Fracture Risk Assessment Tool (FRAX®) was developed to estimate the 10-year absolute probability of osteoporotic fractures among the general population.…
Abstract Number: 2476 • ACR Convergence 2024
The Impact of Systemic Sclerosis Manifestations on Survival and Humanistic Burden: A Targeted Literature Review
vanessa smith¹, Zoe Marjenberg² and Elizabeth Volkmann³, ¹Ghent University Hospital, Gent, Belgium, ²Maverex Ltd, North Shields, United Kingdom, ³University of California, Department of Medicine, Los Angeles, CA, USA, Los Angeles
Background/Purpose: Systemic sclerosis (SSc) is a rare autoimmune disease with multiple disease manifestations, including cutaneous fibrosis, musculoskeletal inflammation, Raynaud phenomenon, calcinosis and digital ulceration. Internal…
Abstract Number: 0490 • ACR Convergence 2024
Improvements in Peri-fracture Care in Rheumatoid Arthritis (RA) Have Offset Increased Mortality
Owen Taylor-Williams¹, Johannes Nossent² and Charles Inderjeeth³, ¹University of Western Australia, Perth, Western Australia, Australia, ²University of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia, ³SCGH and OPH Group & University of Western Australia, Perth, Western Australia, Australia
Background/Purpose: Hip or pelvis fractures (HOP) are common osteoporotic fractures (OP) with significant risks of medical complications, placement into care, reduced quality of life and…
Abstract Number: 1033 • ACR Convergence 2024
Osteoporosis and Cardiovascular Disease: Mortality Trends Among Adults in the United States from 1999 to 2020
Muhammad Naveed¹, Farman Ali², Ahila Ali¹, Bazil Azeem³, Faizan Ahmed⁴, Rabia Iqbal¹, Muhammad Omer Rehan¹, Nouman Shafique⁵, Syed Ishaq⁶, Aman Ullah⁷ and Sherif Eltawansy⁸, ¹Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan, ²Corewell Health, Dearborn Hospital, Dearborn, MI, Dearborn, MI, ³Shaheed Mohtarma Benazir Bhutto Medical College Liyari, Karachi, Pakistan, ⁴Ameer-ud-Din Medical College, Lahore, Pakistan, ⁵AdventHealth Orlando, Orlando, FL, ⁶Sinai Hospital of Baltimore, Baltimore, MD, ⁷SSM Health St Louis University Hospital, St. Louis, MO, ⁸Jersey Shore University Medical Centre, Neptune, NJ
Background/Purpose: Osteoporosis and cardiovascular disease (CVD) represent significant public health concerns. This study investigates the trends and demographic disparities in mortality due to osteoporosis and…
Abstract Number: 2148 • ACR Convergence 2024
Impact of Hip Fractures in the Elderly Population: Functional Status, Readmission, and One-Year Mortality
Belén Miguel Ibáñez¹, Rosa Sepúlveda Correa², Carmen Pablos Hernández³, Marta Ibáñez Martínez¹, Carolina Cristina Chacón Vélez⁴, Laura Blanco Ramis⁴, Sergio Cimadevila Santiago¹, Olga Martínez González⁴, Ana Isabel Turrión Nieves⁴, Manuel Cipriano Martín Martínez⁴, Cristina Hidalgo Calleja¹, Carlos Montilla Morales¹, Olga Compán Fernández⁴, Lourdes Lorenzo Rodríguez¹, José Vicente Hernández Madrid¹, Susana Gómez Castro⁴, Juan Francisco Blanco Blanco⁵ and Alfonso González Ramírez³, ¹University Healthcare Complex of Salamanca, Rheumatology, Salamanca, Spain, ²Department of Statistics, Faculty of Medicine of Salamanca, Salamanca, Spain, ³University Healthcare Complex of Salamanca, Geriatric, Salamanca, Spain, ⁴University Healthcare Complex of Salamanca, Rheumatology, Salamanca, Castilla y Leon, Spain, ⁵University Healthcare Complex of Salamanca Traumatology, Salamanca, Spain
Background/Purpose: Osteoporosis is a common condition in elderly patients. Associated hip fractures lead to the appearance of various complications and increased mortality. The objective of…
Abstract Number: 2493 • ACR Convergence 2024
Mortality in Anti-neutrophil Cytoplasmic Antibody-Associated Vasculitis: Study from a Single University Hospital
Fabricio Benavides¹, Alba Herrero-Morant², Diana Prieto-Peña³, Vanesa Calvo-Rio⁴, Salma Al Fazazi⁵, Adrián Martín-Gutiérrez⁶, Mónica Renuncio-García⁷, Amparo Sánchez-López⁸, Claudia Poo-fernandez⁸, Clara Escagedo-Cagigas⁸, Maria Rodríguez-Vidriales¹ and Ricardo Blanco-Alonso⁹, ¹Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, ²Hospital Universitario Marqués de Valdecilla, Ontinyent, Cantabria, Spain, ³Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Cantabria, Spain, ⁴Valdecilla Hospital, Santander, Cantabria, Spain, ⁵Hospital Universitario Virgen de la Victoria, Málaga, Andalucia, Spain, ⁶Hospital Universitario Marques de Valdecilla, IDIVAL, Renedo de Piélagos, Cantabria, Spain, ⁷Division of Immunology, Hospital Universitario Marqués de Valdecilla, Immunopathology Group, IDIVAL, Santander, Spain, ⁸Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain, ⁹Division of Rheumatology, Hospital Universitario Marqués de Valdecilla. IDIVAL, Immunopathology group, Santander, Spain
Background/Purpose: Anti-neutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) includes Granulomatosis with polyangiitis (GPA), Microscopic polyarteritis (MPA) and Eosinophilic granulomatosis with polyangiitis (EGPA). Due to clinical,…
Abstract Number: 0645 • ACR Convergence 2023
Continuous Progressive ILD in Systemic Sclerosis Is Associated with Mortality
Anna-Maria Hoffmann-Vold¹, Liubov Petelytska², Havard Fretheim¹, Trond Mogens Aaløkken³, Mike Becker⁴, Cathrine Brunborg⁵, Cosimo Bruni⁶, Christian Clarenbach⁷, Phuong Phuong Diep⁸, Rucsandra Dobrota⁶, Michael Durheim⁹, Muriel Elhai¹⁰, Thomas Frauenfelder¹¹, Suzana Jordan⁶, Emily Langballe¹², Oyvind Midtvedt¹, Carina Mihai⁶, Oyvind Molberg¹³ and Oliver Distler⁶, ¹Oslo University Hospital, Oslo, Norway, ²Bogomolets National Medical University, Kyiv, Ukraine, ³Dept of Radiology, Oslo University Hospital, Oslo, Norway, ⁴Department of Rheumatology, University Hospital Zurich, University of Zurich, Zürich, Switzerland, ⁵Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital - Rikshospitalet, Oslo, Norway, ⁶Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁷Dept of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ⁸Dept of Respiratory diseases, University Hospital Oslo, Oslo, Norway, ⁹Dept of Respiratory diseases, Oslo University Hospital, Oslo, Norway, ¹⁰University Hospital zurich, University of Zurich, Zurich, Switzerland, ¹¹Dept of Radiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland, ¹²Universitetet i Oslo, Oslo, Norway, ¹³Dept of Rheumatology, University Hospital Oslo, Oslo, Norway
Background/Purpose: We have previously shown that short term progression of interstitial lung disease (ILD) in systemic sclerosis (SSc) is associated with mortality. However, it is…

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