ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstracts tagged "monocytes"

  • Abstract Number: 187 • 2016 ACR/ARHP Annual Meeting

    Commensal Microbiota Tune Systemic Toll-like Receptor-Mediated Inflammatory Responses

    Lehn K. Weaver1, Chhanda Biswas1 and Edward M. Behrens2, 1Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, 2Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA

    Background/Purpose: Although commensal microbiota are thought to contribute to the development of autoimmunity, the cellular and molecular mechanisms connecting changes in gut microbiota to the…
  • Abstract Number: 1130 • 2016 ACR/ARHP Annual Meeting

    Aminopeptidase N/CD13 Induces Monocyte Migration in Vitro and In Vivo and Signals through GPCR, Erk1/2, Jnk, Src, and NFκB

    Yuxuan Du1, W. Alexander Stinson2, Phillip Campbell1, Rachel Morgan1, Nicholas Lepore1, Ellen Cealey1, Jonatan Hervoso1, Huadong Cui2, David Fox3 and M. Asif Amin4, 1Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, 4Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI

    Background/Purpose: Aminopeptidase N/CD13 is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS). It is found in soluble form in serum and rheumatoid…
  • Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting

    Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation

    Carlos Perez-Sanchez1, Maria Ángeles Aguirre Zamorano1, María Galindo2, Patricia Ruiz-Limon3, Ivan Arias de la Rosa3, Nuria Barbarroja1, Yolanda Jiménez-Gómez1, Pedro Segui1, Eduardo Collantes-Estévez1, Maria Jose Cuadrado4 and Chary Lopez-Pedrera1, 1Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 2Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, 3Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, 4St Thomas Hospital, Lupus Research Unit, London, United Kingdom

    Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
  • Abstract Number: 3220 • 2016 ACR/ARHP Annual Meeting

    Distinct Single Cell Gene Expression Signatures of Monocyte Subsets Differentiate Between TNF-Alpha Inhibitor Treatment Response Groups in Rheumatoid Arthritis

    Theresa L. Wampler Muskardin1, Wei Fan2, Zhongbo Jin3, Mark A. Jensen4, Jessica M. Dorschner3, Yogita Ghodke-Puranik3, Kerry Wright1, John M. Davis III5, Eric L. Matteson1, Clement Michet Jr.1, Thomas G. Mason II6, Scott T. Persellin7, Daniel Schaffer1, Betty Dicke1, Danielle Vsetecka3 and Timothy B. Niewold8, 1Rheumatology, Mayo Clinic, Rochester, MN, 2Mayo Clinic, Rochester, MN, 3Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, 4Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, 5Division of Rheumatology, Mayo Clinic, Rochester, MN, 6Division of Rheumatology - Department of Medicine, Mayo Clinic Rochester, Rochester, MN, 7Department of Rheumatology, Mayo Clinic Rochester, Rochester, MN, 8Rheumatology and Immunology, Mayo Clinic, Rochester, MN

    Background/Purpose: In rheumatoid arthritis (RA), initiating effective treatment as soon as possible within the so-called therapeutic “window of opportunity” is the strategy, and remission is…
  • Abstract Number: 2823 • 2015 ACR/ARHP Annual Meeting

    Gut Inflammation in HLA-B27 Transgenic Rats Alters the Monocyte Compartment and Its Osteoclastogenic Potential

    C. Ansalone, L. Utriainen, S. W. F. Milling and C. S. Goodyear, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom

    Background/Purpose: Human HLA-B27 and β2-microglobulin transgenic rats (B27 rats), an animal model for spondyloarthropathies, spontaneously develop inflammatory colitis and bone loss. We have previously demonstrated…
  • Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting

    Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous

    Goh Murayama1, Asako Chiba2, Ken Yamaji3, Naoto Tamura3, Yoshinari Takasaki3 and Sachiko Miyake2, 1Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, 2Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, 3Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan

    Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
  • Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting

    Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes

    Antonella Farina1, Giovanna Peruzzi2,3, Valentina Lacconi4, Edoardo Rosato5, Silvia Quarta6, Stefania Morrone1, Alberto Faggioni1, Maria Trojanowska4 and Giuseppina Alessandra Farina4, 1Department of Experimental Medicine, Sapienza University, Department of Experimental Medicine, Rome, Italy, 2Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Rome, Italy, 3Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Viale Regina Elena 291, 00161, Rome, Italy, Rome, Italy, 4Arthritis Center, Boston University, Arthritis Center, Boston, MA, 5Department of Clinical Medicine, Clinical Immunology Unit,, Sapienza University,Department of Clinical Medicine, Rome, Italy, 6Department of Clinical Medicine, Clinical Immunology Unit., Sapienza University,Department of Clinical Medicine, Rome, Italy

    Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…
  • Abstract Number: 1140 • 2015 ACR/ARHP Annual Meeting

    Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis

    Antonia Puchner1, Victoria Saferding2, Eliana Goncalves-Alves3, Michael Bonelli3, Silvia Hayer4, Carl-Walter Steiner2, Birgit Niederreiter5, Josef S. Smolen1, Kurt Redlich3 and Stephan Blüml3, 1Department of Rheumatology, Medical University of Vienna, Vienna, Austria, 2Rheumatology, Medical University of Vienna, Vienna, Austria, 3Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 4Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, 5Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria

    Background/Purpose: Bone destruction in rheumatoid arthritis is mediated by osteoclasts, which are derived from precursor cells of the myeloid lineage.  Although there is much known…
  • Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting

    Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis

    Sang-Yeob Lee1, Sung Won Lee2, Won Tae Chung2, Jae Ho Bae3, So Youn Park4 and Chi Dae Kim4, 1Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, 2Rheumatology, Dong-A University Hospital, Busan, South Korea, 3Biochemistry, Pusan national university, Yong -San, South Korea, 4Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea

    Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…
  • Abstract Number: 1978 • 2014 ACR/ARHP Annual Meeting

    Role of Monocytes Subsets in the Pathology of Rheumatoid Arthritis: Involvement in Endothelial Dysfunction and Proinflammatory Profile

    Chary Lopez-Pedrera, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Rosario Carretero, Yolanda Jiménez Gómez, Ángeles Aguirre Zamorano, Jerusalem calvo-Gutierrez, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras and Nuria Barbarroja, Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain

    Background/Purpose Different frequency of monocytes subsets has been reported in rheumatoid arthritis (RA).Human monocytes are divided into three main subpopulations according to expression of the…
  • Abstract Number: 1042 • 2014 ACR/ARHP Annual Meeting

    IL-1β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression By Rheumatoid Arthritis Synovial Fibroblasts

    Christelle Darrieutort-Laffite1,2, Marie Astrid Boutet1, Mathias Chatelais1, Regis Brion3, Frederic Blanchard1, Dominique Heymann3 and Benoit Le Goff1,2, 1Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, INSERM, UMR 957, Nantes, France, 2Rheumatology, Nantes University Hospital, Nantes, France, 3Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, INSERM, UMR 957, Nantes, France

    Background/Purpose Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). They can interact in the synovial micro-environment…
  • Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting

    A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis

    W. Alexander Stinson1, Phillip L. Campbell1, Jeffrey Ruth2, Gautam Edhayan2, Ray A. Ohara2, Nicholas Lepore3, Alisa E. Koch4, David A. Fox2 and M. Asif Amin2, 1Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 2Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 3University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, 4Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI

    Background/Purpose:  Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
  • Abstract Number: 609 • 2014 ACR/ARHP Annual Meeting

    Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role of Different Cell Types in the Disease Process of Spondyloarthritis Pathogenesis

    Gerlinde Layh-Schmitt1, Shjia Lu2, Fatemeh Navid2, Massimo Gadina2 and Robert A. Colbert2, 110 Center Drive., NIAMS/NIH, Bethesda, MD, 2NIAMS/NIH, Bethesda, MD

    Background/Purpose: Many genetic factors and cell types contribute to the axial inflammation, trabecular bone loss, and aberrant bone formation that result in ankylosing spondylitis. The…
  • Abstract Number: 39 • 2014 ACR/ARHP Annual Meeting

    Human CD14+ Monocytes Stimulated with a Combination of TNFα and IL-6 Differentiate into Osteoclast-like Cells with Bone-Resorption Activity

    Kazuhiro Yokota1, Kojiro Sato2, Yoshimi Aizaki2, Yuji Akiyama2 and Toshihide Mimura2, 1Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, 2Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan

    Background/Purpose Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
  • Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting

    Novel Role For Ly6C– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis

    Alexander Misharin1, Carla M. Cuda2, Rana Saber3, Angelica K. Gierut4, G. Kenneth Haines III5, Steffen Jung6 and Harris R. Perlman7, 1Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, 2Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Medicine/Rheumatology, Northwestern University, Chicago, IL, 4Rheumatology, Northwestern Med Faculty Found, Chicago, IL, 5Department of Pathology, Yale University, New Haven, CT, 6Immunology, Weizmann Institute, Rehovot, Israel, 7Northwestern University Feinberg School of Medicine, Chicago, IL

    Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…
  • « Previous Page
  • 1
  • 2
  • 3
  • Next Page »
Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology