Abstracts tagged "monocytes"

Abstract Number: 1130 • 2016 ACR/ARHP Annual Meeting
Aminopeptidase N/CD13 Induces Monocyte Migration in Vitro and In Vivo and Signals through GPCR, Erk1/2, Jnk, Src, and NFκB
Yuxuan Du¹, W. Alexander Stinson², Phillip Campbell¹, Rachel Morgan¹, Nicholas Lepore¹, Ellen Cealey¹, Jonatan Hervoso¹, Huadong Cui², David Fox³ and M. Asif Amin⁴, ¹Rheumatology, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³Department of Medicine [Division of Rheumatology], University of Michigan, Ann Arbor, MI, ⁴Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI
Background/Purpose: Aminopeptidase N/CD13 is a metalloproteinase expressed on the surface of fibroblast like synoviocytes (FLS). It is found in soluble form in serum and rheumatoid…
Abstract Number: 2066 • 2016 ACR/ARHP Annual Meeting
Anti-Ds-DNA Antibodies Regulate Atherothrombosis in Systemic Lupus Erythematosus through the Induction of Netosis, the Prothrombotic and Proinflammatory Activities of Monocytes and the Endothelial Activation
Carlos Perez-Sanchez¹, Maria Ángeles Aguirre Zamorano¹, María Galindo², Patricia Ruiz-Limon³, Ivan Arias de la Rosa³, Nuria Barbarroja¹, Yolanda Jiménez-Gómez¹, Pedro Segui¹, Eduardo Collantes-Estévez¹, Maria Jose Cuadrado⁴ and Chary Lopez-Pedrera¹, ¹Rheumatology service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ²Servicio de Reumatología, Hospital 12 de Octubre, Madrid, Spain, ³Rheumatology Service, IMIBIC/Reina Sofia Hospital/University of Cordoba, Cordoba, Spain, ⁴St Thomas Hospital, Lupus Research Unit, London, United Kingdom
Background/Purpose: The role of anti-dsDNA in the pathogenesis of the systemic lupus erythematosus (SLE) has been clearly established. However, the influence of these autoantibodies in…
Abstract Number: 3220 • 2016 ACR/ARHP Annual Meeting
Distinct Single Cell Gene Expression Signatures of Monocyte Subsets Differentiate Between TNF-Alpha Inhibitor Treatment Response Groups in Rheumatoid Arthritis
Theresa L. Wampler Muskardin¹, Wei Fan², Zhongbo Jin³, Mark A. Jensen⁴, Jessica M. Dorschner³, Yogita Ghodke-Puranik³, Kerry Wright¹, John M. Davis III⁵, Eric L. Matteson¹, Clement Michet Jr.¹, Thomas G. Mason II⁶, Scott T. Persellin⁷, Daniel Schaffer¹, Betty Dicke¹, Danielle Vsetecka³ and Timothy B. Niewold⁸, ¹Rheumatology, Mayo Clinic, Rochester, MN, ²Mayo Clinic, Rochester, MN, ³Division of Rheumatology and Department of Immunology, Mayo Clinic, Rochester, MN, ⁴Department of Immunology and Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁵Division of Rheumatology, Mayo Clinic, Rochester, MN, ⁶Division of Rheumatology - Department of Medicine, Mayo Clinic Rochester, Rochester, MN, ⁷Department of Rheumatology, Mayo Clinic Rochester, Rochester, MN, ⁸Rheumatology and Immunology, Mayo Clinic, Rochester, MN
Background/Purpose: In rheumatoid arthritis (RA), initiating effective treatment as soon as possible within the so-called therapeutic “window of opportunity” is the strategy, and remission is…
Abstract Number: 187 • 2016 ACR/ARHP Annual Meeting
Commensal Microbiota Tune Systemic Toll-like Receptor-Mediated Inflammatory Responses
Lehn K. Weaver¹, Chhanda Biswas¹ and Edward M. Behrens², ¹Pediatric Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA
Background/Purpose: Although commensal microbiota are thought to contribute to the development of autoimmunity, the cellular and molecular mechanisms connecting changes in gut microbiota to the…
Abstract Number: 1140 • 2015 ACR/ARHP Annual Meeting
Resident Non-Classical Monocytes Are Critically Important for Tissue Destruction in Arthritis
Antonia Puchner¹, Victoria Saferding², Eliana Goncalves-Alves³, Michael Bonelli³, Silvia Hayer⁴, Carl-Walter Steiner², Birgit Niederreiter⁵, Josef S. Smolen¹, Kurt Redlich³ and Stephan Blüml³, ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁵Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: Bone destruction in rheumatoid arthritis is mediated by osteoclasts, which are derived from precursor cells of the myeloid lineage. Although there is much known…
Abstract Number: 2569 • 2015 ACR/ARHP Annual Meeting
Regulation of SIRT1 Maybe a Perfect Strategy in Treatment of Rheumatoid Arthritis
Sang-Yeob Lee¹, Sung Won Lee², Won Tae Chung², Jae Ho Bae³, So Youn Park⁴ and Chi Dae Kim⁴, ¹Division of Rheumatology, Department of Internal Medicine, Dong-A University College of Medicine, Busan, South Korea, ²Rheumatology, Dong-A University Hospital, Busan, South Korea, ³Biochemistry, Pusan national university, Yong -San, South Korea, ⁴Medical Research Center for Ischemic Tissue Regeneration, Pusan national university, Yong -San, South Korea
Background/Purpose: Monocyte may differentiate to osteoclasts in bone and macrophages in joint. so, blocking of monocyte differentiation maybe effective target in RA (rheumatoid arthritis) treatment.…
Abstract Number: 2823 • 2015 ACR/ARHP Annual Meeting
Gut Inflammation in HLA-B27 Transgenic Rats Alters the Monocyte Compartment and Its Osteoclastogenic Potential
C. Ansalone, L. Utriainen, S. W. F. Milling and C. S. Goodyear, Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary Medicine and Life Sciences, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Human HLA-B27 and β2-microglobulin transgenic rats (B27 rats), an animal model for spondyloarthropathies, spontaneously develop inflammatory colitis and bone loss. We have previously demonstrated…
Abstract Number: 3027 • 2015 ACR/ARHP Annual Meeting
Hyperactivated State of Mucosal Associated Invariant T Cells Due to Activation Potency of Monocytes in Systemic Lupus Erythematous
Goh Murayama¹, Asako Chiba², Ken Yamaji³, Naoto Tamura³, Yoshinari Takasaki³ and Sachiko Miyake², ¹Department of Internal Medicine and Rheumatology,, Juntendo University School of Medicine, Tokyo, Japan., Tokyo, Japan, ²Division of Immunology/NCNP, Natl Institute of Neuroscience, Kodaira Tokyo, Japan, ³Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine, Tokyo, Japan
Background/Purpose: Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes that express a semi-invariant TCRα chain: Vα7.2-Jα33 in humans and Vα19-Jα33 in mice. MAIT cells are…
Abstract Number: 3130 • 2015 ACR/ARHP Annual Meeting
Epstein-Barr Virus Induces Activation of Infammatory Markers Via the TLR8 Transduction Pathway in Infected Scleroderma Monocytes
Antonella Farina¹, Giovanna Peruzzi^2,3, Valentina Lacconi⁴, Edoardo Rosato⁵, Silvia Quarta⁶, Stefania Morrone¹, Alberto Faggioni¹, Maria Trojanowska⁴ and Giuseppina Alessandra Farina⁴, ¹Department of Experimental Medicine, Sapienza University, Department of Experimental Medicine, Rome, Italy, ²Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Rome, Italy, ³Istituto Italiano di Tecnologia (IIT), CLNS@Sapienza, Viale Regina Elena 291, 00161, Rome, Italy, Rome, Italy, ⁴Arthritis Center, Boston University, Arthritis Center, Boston, MA, ⁵Department of Clinical Medicine, Clinical Immunology Unit,, Sapienza University,Department of Clinical Medicine, Rome, Italy, ⁶Department of Clinical Medicine, Clinical Immunology Unit., Sapienza University,Department of Clinical Medicine, Rome, Italy
Background/Purpose: Monocytes from patients with systemic sclerosis (Scleroderma, SSc), are characterized by the increased expression of IFN-regulatory genes, implicating dysregulation of the innate immune response…
Abstract Number: 1978 • 2014 ACR/ARHP Annual Meeting
Role of Monocytes Subsets in the Pathology of Rheumatoid Arthritis: Involvement in Endothelial Dysfunction and Proinflammatory Profile
Chary Lopez-Pedrera, Patricia Ruiz-Limon, Carlos Perez-Sanchez, Rosario Carretero, Yolanda Jiménez Gómez, Ángeles Aguirre Zamorano, Jerusalem calvo-Gutierrez, Eduardo Collantes-Estevez, Alejandro Escudero-Contreras and Nuria Barbarroja, Rheumatology Unit, IMIBIC-Reina Sofia University Hospital, Cordoba, Spain
Background/Purpose Different frequency of monocytes subsets has been reported in rheumatoid arthritis (RA).Human monocytes are divided into three main subpopulations according to expression of the…
Abstract Number: 1042 • 2014 ACR/ARHP Annual Meeting
IL-1β and TNF-α Promote Monocyte Viability through the Induction of GM-CSF Expression By Rheumatoid Arthritis Synovial Fibroblasts
Christelle Darrieutort-Laffite^1,2, Marie Astrid Boutet¹, Mathias Chatelais¹, Regis Brion³, Frederic Blanchard¹, Dominique Heymann³ and Benoit Le Goff^1,2, ¹Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, INSERM, UMR 957, Nantes, France, ²Rheumatology, Nantes University Hospital, Nantes, France, ³Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Nantes, INSERM, UMR 957, Nantes, France
Background/Purpose Macrophages and synovial fibroblasts (SF) are two major cells implicated in the pathogenesis of rheumatoid arthritis (RA). They can interact in the synovial micro-environment…
Abstract Number: 937 • 2014 ACR/ARHP Annual Meeting
A Unique Role for IL-18 Receptor-α in Monocyte Migration in RA and K/BxN Serum Transfer Arthritis
W. Alexander Stinson¹, Phillip L. Campbell¹, Jeffrey Ruth², Gautam Edhayan², Ray A. Ohara², Nicholas Lepore³, Alisa E. Koch⁴, David A. Fox² and M. Asif Amin², ¹Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ³University of Michigan, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ⁴Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
Background/Purpose: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by monocyte (MN) recruitment. Proinflammatory cytokines and their corresponding receptors play an important role in…
Abstract Number: 609 • 2014 ACR/ARHP Annual Meeting
Induced Pluripotent Stem Cells (iPSCs) As a Tool for Unraveling the Role of Different Cell Types in the Disease Process of Spondyloarthritis Pathogenesis
Gerlinde Layh-Schmitt¹, Shjia Lu², Fatemeh Navid², Massimo Gadina² and Robert A. Colbert², ¹10 Center Drive., NIAMS/NIH, Bethesda, MD, ²NIAMS/NIH, Bethesda, MD
Background/Purpose: Many genetic factors and cell types contribute to the axial inflammation, trabecular bone loss, and aberrant bone formation that result in ankylosing spondylitis. The…
Abstract Number: 39 • 2014 ACR/ARHP Annual Meeting
Human CD14⁺ Monocytes Stimulated with a Combination of TNFα and IL-6 Differentiate into Osteoclast-like Cells with Bone-Resorption Activity
Kazuhiro Yokota¹, Kojiro Sato², Yoshimi Aizaki², Yuji Akiyama² and Toshihide Mimura², ¹Department of Rheumatology & Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan, ²Department of Rheumatology and Applied Immunology, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Background/Purpose Proinflammatory cytokines play an important role in bone destruction in rheumatoid arthritis (RA), as inferred by the efficacy of biologics. Previously, we reported that…
Abstract Number: 1730 • 2013 ACR/ARHP Annual Meeting
Novel Role For Ly6C^– Monocyte Subsets and Joint Macrophages In Mouse Model Of Rheumatoid Arthritis
Alexander Misharin¹, Carla M. Cuda², Rana Saber³, Angelica K. Gierut⁴, G. Kenneth Haines III⁵, Steffen Jung⁶ and Harris R. Perlman⁷, ¹Medicine, Division of Rheumatology, Northwestern University, Chicago, IL, ²Medicine / Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Medicine/Rheumatology, Northwestern University, Chicago, IL, ⁴Rheumatology, Northwestern Med Faculty Found, Chicago, IL, ⁵Department of Pathology, Yale University, New Haven, CT, ⁶Immunology, Weizmann Institute, Rehovot, Israel, ⁷Northwestern University Feinberg School of Medicine, Chicago, IL
Background/Purpose: Monocytes and macrophages play a key role in the pathogenesis of rheumatoid arthritis. However, role of the individual subsets of monocytes and macrophages in…

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