ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "monocytes and transforming growth factor"

  • Abstract Number: 125 • 2018 ACR/ARHP Annual Meeting

    Monocyte Transcriptome Delineates SSc Patients with Functionally Distinct Patterns of Gene Dysregulation That Persist through Differentiation

    Julia L.M. Dunn1, Philip J. Homan2, Salina Dominguez1, Carla M. Cuda1, Kathleen Aren3, Mary A. Carns3,4, Tracy M. Frech5, Dinesh Khanna6, Shervin Assassi7, Harris Perlman1, Monique Hinchcliff1 and Deborah R. Winter1, 1Department of Medicine Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 2Division of Rheumatology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, 3Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, 4Department of Medicine, Division of Rheumatology, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Division of Rheumatology, University of Utah, Salt Lake City, UT, 6Division of Rheumatology, University of Michigan, Ann Arbor, MI, 7Rheumatology, University of Texas Health Science Center at Houston, Houston, TX

    Background/Purpose: The etiology and pathogenesis of SSc are poorly understood; however, an increasing body of evidence supports an early inflammatory phase that precedes, and may…
  • Abstract Number: 1361 • 2015 ACR/ARHP Annual Meeting

    Synovial Macrophages Promote TGF-β Signaling but Protect Against Influx of S100A8/S100A9-Producing Cells after Intra-Articular Injections of Oxidized Low-Density Lipoproteins

    Wouter de Munter1, Martijn H. van den Bosch1, Arjen Blom1, Birgitte Walgreen2, Monique Helsen1, Leo Joosten3, Johannes Roth4, Thomas Vogl5, Fons van de Loo1, Marije Koenders1, Wim van den Berg1, Peter van der Kraan1 and Peter van Lent1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Experimentel Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 3Internal Medicine, Radboud university medical center, Nijmegen, Netherlands, 4Institute of Immunology, University of Münster, Münster, Germany, 5University of Muenster, Muenster, Germany

    Background/Purpose:  In previous studies we found that synovial macrophages regulate joint pathology during experimental osteoarthritis (OA). Recently, we found that high systemic levels of LDL…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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