Abstracts tagged "monocytes and systemic sclerosis"

Abstract Number: 1112 • 2018 ACR/ARHP Annual Meeting
Downregulated Expression of Interferon Regulatory Factor 8 in Circulating Monocytes Exhibits Pro-Fibrotic Phenotype in Patients with Systemic Sclerosis
Yasushi Ototake¹, Yukie Yamaguchi¹, Miho Asami¹, Noriko Ikeda¹, Daisuke Kurotaki², Tomohiko Tamura² and Michiko Aihara¹, ¹Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ²Department of Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
Background/Purpose: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by autoimmunity, vasculopathy, and excessive organ fibrosis. Although the etiology of the disease is…
Abstract Number: 1718 • 2017 ACR/ARHP Annual Meeting
The Role and Function of Monocyte-Derived Fibroblast-like Cells in Multi-Organ Fibrosis in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato¹, Vincent Milleret², Przemyslaw Blyszczuk^1,3, Britta Maurer¹, Karin Klingel⁴, Joerg C. Henes⁵, Karl Sotlar⁶, Martin Ehrbar², Oliver Distler⁷ and Gabriela Kania¹, ¹Department of Rheumatology, Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Obstetrics, University Hospital Zurich, Zurich, Switzerland, ³Department of Clinical Immunology, Jagiellonian University Medical College, Krakow, Poland, ⁴Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁵Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ⁶Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁷Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland
Background/Purpose: Animal studies indicated bone marrow-derived cells as a source of pathological myofibroblasts in fibrosis of multiple organ including lungs, heart, skin and kidney. Monocytes…
Abstract Number: 812 • 2016 ACR/ARHP Annual Meeting
Monocytes/Neurotrophins/Myofibroblasts As a Novel Axis in Systemic Sclerosis
Michal Rudnik¹, Mara Stellato¹, Elena Pachera¹, Rucsandra Dobrota¹, Britta Maurer¹, Joerg C. Henes², Karin Klingel³, Karl Sotlar⁴, Przemyslaw Blyszczuk⁵, Oliver Distler¹ and Gabriela Kania¹, ¹Department of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Department of Internal Medicine II, Division of Rheumatology, University Hospital Tuebingen, Tuebingen, Germany, ³Department of Molecular Pathology, University Hospital Tuebingen, Tuebingen, Germany, ⁴Institute of Pathology, Ludwig Maximilians University, Munich, Germany, ⁵Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease, which is characterized by inflammation, fibrosis and vasculopathy in multiple organs, mainly in the lung, heart and…
Abstract Number: 1854 • 2016 ACR/ARHP Annual Meeting
Increased Percentage of CD204/CD206 Double Positive Monocytes Correlates with Specific Lung and Skin Involvement Parameters and an “Active” Capillaroscopic Pattern of Microangiopathy in Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Amelia Chiara Trombetta³, Barbara Ruaro⁴, Sabrina Paolino⁴, Carmen Pizzorni⁴, Renata Brizzolara⁴, Paola Montagna⁴, Alberto Sulli⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genoa, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy, ³Department of Internal Medicine, University of Genova,, Research Laboratory and Academic Division of Clinical Rheumatology, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, Genova, Italy
Background/Purpose: Immune cell activation plays a crucial role in the pathogenesis of systemic sclerosis (SSc), and macrophages may be important mediators in this complex pathway…
Abstract Number: 1923 • 2015 ACR/ARHP Annual Meeting
The Role of Inflammatory Myeloid Cell Compartment in Myocardial Fibrogenesis and Remodelling in Systemic Sclerosis
Veronika Haunerdinger¹, Przemyslaw Blyszczuk², Elena Pachera¹, Rucsandra Dobrota³, Britta Maurer¹, Ulrich Grabmaier⁴, Karl Sotlar⁵, Oliver Distler¹ and Gabriela Kania¹, ¹Research of Systemic Autoimmune Diseases, Division of Rheumatology, University Hospital Zurich, 8952 Schlieren, Switzerland, ²Cardioimmunology, Center of Molecular Cardiology, University of Zurich, 8952 Schlieren, Switzerland, ³Division of Rheumatology, University Hospital Zurich, Zurich, Switzerland, ⁴Medical Clinic und Polyclinic I, Campus Großhadern, Maximilians University Munich, 81377 Munich, Germany, ⁵Institute of Pathology, Ludwig Maximilians University Munich, 81377 Munich, Germany
Background/Purpose: During the last years, there was a shift in systemic sclerosis (SSc)-related causes of death, indicating cardiac involvement and inflammatory dilated cardiomyopathy (iDCM) as…

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